Short- and long-term effects of chromosome mis-segregation and aneuploidy

Targeting the Adaptability of Heterogeneous Aneuploids

(2015) Guangbo Chen et al.   CELL

Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes

(2015) Megan E. Bonney et al.   GENES & DEVELOPMENT

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Unique features of the transcriptional response to model aneuploidy in human cells

(2014) Milena Dürrbaum et al.   BMC GENOMICS

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

(2014) Gene-Wei Li et al.   CELL

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells

(2014) N. Donnelly et al.   EMBO JOURNAL

Signalling dynamics in the spindle checkpoint response

(2014) Nitobe London et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

(2014) Floris Foijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain

(2014) Xuyu Cai et al.   Cell Reports

Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast

(2014) Noah Dephoure et al.   eLife

A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis

(2013) J. M. Sheltzer   CANCER RESEARCH

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Gene Copy-Number Alterations: A Cost-Benefit Analysis

(2013) Yun-Chi Tang et al.   CELL

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

(2013) C.-Z. Zhang et al.   GENES & DEVELOPMENT

Aneuploid yeast strains exhibit defects in cell growth and passage through START

(2013) Rebecca R. Thorburn et al.   MOLECULAR BIOLOGY OF THE CELL

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

(2013) A. D. Silk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mosaic Copy Number Variation in Human Neurons

(2013) M. J. McConnell et al.   SCIENCE

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Chromosomal instability and aneuploidy in cancer: from yeast to man

(2012) Sarah J Pfau et al.   EMBO REPORTS

Aneuploidy causes proteotoxic stress in yeast

(2012) A. B. Oromendia et al.   GENES & DEVELOPMENT

Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method

(2012) K. Makanae et al.   GENOME RESEARCH

Chromosome-specific accumulation of aneuploidy in the aging mouse brain

(2012) Francesca Faggioli et al.   HUMAN MOLECULAR GENETICS

Aneuploidy as a mechanism for stress-induced liver adaptation

(2012) Andrew W. Duncan et al.   JOURNAL OF CLINICAL INVESTIGATION

Robustness analysis of cellular systems using the genetic tug-of-war method

(2012) Hisao Moriya et al.   Molecular BioSystems

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal duplication is a transient evolutionary solution to stress

(2012) A. H. Yona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

(2012) Jin Zhu et al.   PLoS Genetics

Human Copy Number Variation and Complex Genetic Disease

(2011) Santhosh Girirajan et al.   Annual Review of Genetics

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

(2011) Pengfei Liu et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Buffering and the evolution of chromosome-wide gene regulation

(2011) Per Stenberg et al.   CHROMOSOMA

Whole-Chromosome Aneuploidy Analysis in Human Oocytes: Focus on Comparative Genomic Hybridization

(2011) A. Obradors et al.   CYTOGENETIC AND GENOME RESEARCH

Aneuploidy in Human Spermatozoa

(2011) C. Templado et al.   CYTOGENETIC AND GENOME RESEARCH

Frequent Aneuploidy Among Normal Human Hepatocytes

(2011) Andrew W. Duncan et al.   GASTROENTEROLOGY

Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression

(2011) J. C. Kim et al.   GENES & DEVELOPMENT

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear envelope defects impede a proper response to micronuclear DNA lesions

(2011) Mariona Terradas et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

(2011) Bing Xu et al.   PLoS One

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

pRB, a tumor suppressor with a stabilizing presence

(2011) Amity L. Manning et al.   TRENDS IN CELL BIOLOGY

Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome

(2011) David Venet et al.   PLoS Computational Biology

Differential Gene Expression and Epiregulation of Alpha Zein Gene Copies in Maize Haplotypes

(2011) Mihai Miclaus et al.   PLoS Genetics

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

Statistical Analysis of Nondisjunction Assays in Drosophila

(2010) Y. Zeng et al.   GENETICS

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia

(2010) Letetia Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

(2010) Séverine Boulon et al.   MOLECULAR CELL

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

(2010) Rocio Sotillo et al.   NATURE

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe

(2010) Dong-Uk Kim et al.   NATURE BIOTECHNOLOGY

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA lesions sequestered in micronuclei induce a local defective-damage response

(2009) Mariona Terradas et al.   DNA REPAIR

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

(2009) Kwan-Hyuck Baek et al.   NATURE

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

(2008) Giulia Rancati et al.   CELL

Aneuploidy: Cells Losing Their Balance

(2008) Eduardo M. Torres et al.   GENETICS

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

(2008) Thomas E. Sussan et al.   NATURE

Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis

(2008) Z N Demidenko et al.   ONCOGENE

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Effects of Aneuploidy on Genome Structure, Expression, and Interphase Organization in Arabidopsis thaliana

(2008) Bruno Huettel et al.   PLoS Genetics