A unique binding mode of Nek2A to the APC /C allows its ubiquitination during prometaphase
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Title
A unique binding mode of Nek2A to the
APC
/C allows its ubiquitination during prometaphase
Authors
Keywords
-
Journal
EMBO REPORTS
Volume -, Issue -, Pages -
Publisher
EMBO
Online
2020-04-20
DOI
10.15252/embr.201949831
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Note: Only part of the references are listed.- Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
- (2019) Suyang Zhang et al. Nature Communications
- Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION
- (2018) Takanori Nakane et al. eLife
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division
- (2018) Edmond R. Watson et al. TRENDS IN CELL BIOLOGY
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)
- (2017) Claudio Alfieri et al. Open Biology
- Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
- (2016) Nicholas G. Brown et al. CELL
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Recombinant expression and reconstitution of multiprotein complexes by the USER cloning method in the insect cell-baculovirus expression system
- (2016) Ziguo Zhang et al. METHODS
- The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C
- (2016) Barbara Di Fiore et al. MOLECULAR CELL
- Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation
- (2016) Masaya Yamaguchi et al. MOLECULAR CELL
- Molecular mechanism of APC/C activation by mitotic phosphorylation
- (2016) Suyang Zhang et al. NATURE
- Molecular basis of APC/C regulation by the spindle assembly checkpoint
- (2016) Claudio Alfieri et al. NATURE
- The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity
- (2016) Thomas Wild et al. Cell Reports
- Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint
- (2016) Eelco Tromer et al. Open Biology
- Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C
- (2016) Dimitriya H. Garvanska et al. Biology Open
- The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics
- (2015) Andrea Musacchio CURRENT BIOLOGY
- The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators
- (2015) Barbara Di Fiore et al. DEVELOPMENTAL CELL
- Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20
- (2015) M. Boekhout et al. JOURNAL OF CELL SCIENCE
- Atomic structure of the APC/C and its mechanism of protein ubiquitination
- (2015) Leifu Chang et al. NATURE
- RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex
- (2015) Nicholas G. Brown et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced Protein Degradation by Branched Ubiquitin Chains
- (2014) Hermann-Josef Meyer et al. CELL
- The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
- (2014) Daisuke Izawa et al. NATURE
- Molecular architecture and mechanism of the anaphase-promoting complex
- (2014) Leifu Chang et al. NATURE
- Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C–Cdc20 complex
- (2013) Garry G Sedgwick et al. EMBO JOURNAL
- Panta rhei: The APC/C at steady state
- (2013) Ivana Primorac et al. JOURNAL OF CELL BIOLOGY
- Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates
- (2013) M. Min et al. Open Biology
- Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C)
- (2012) Ziguo Zhang et al. BIOCHEMICAL JOURNAL
- The APC/C Subunit Mnd2/Apc15 Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation
- (2012) Scott A. Foster et al. MOLECULAR CELL
- Structure of the mitotic checkpoint complex
- (2012) William C. H. Chao et al. NATURE
- APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex
- (2012) Kristina Uzunova et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment
- (2011) Jörg Mansfeld et al. NATURE CELL BIOLOGY
- Processive ubiquitin chain formation by the anaphase-promoting complex
- (2011) Hermann-Josef Meyer et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
- (2010) Jasmin N Dynek et al. EMBO JOURNAL
- How cyclin A destruction escapes the spindle assembly checkpoint
- (2010) Barbara Di Fiore et al. JOURNAL OF CELL BIOLOGY
- Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor
- (2010) Paula C. A. da Fonseca et al. NATURE
- BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
- (2009) Eunhee Choi et al. EMBO JOURNAL
- Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex
- (2008) Lingyan Jin et al. CELL
- The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC
- (2008) Matthew K. Summers et al. MOLECULAR CELL
- A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment
- (2008) Yuu Kimata et al. MOLECULAR CELL
- The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
- (2008) Jakob Nilsson et al. NATURE CELL BIOLOGY
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