Molecular architecture and mechanism of the anaphase-promoting complex

Ubiquitin Ligases and Cell Cycle Control

(2013) Leonardo K. Teixeira et al.   Annual Review of Biochemistry

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

The Four Canonical TPR Subunits of Human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelix

(2013) Ziguo Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

(2013) Jun He et al.   MOLECULAR CELL

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex

(2013) Weiping Wang et al.   NATURE CELL BIOLOGY

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

(2013) Jeremiah J Frye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C)

(2012) Ziguo Zhang et al.   BIOCHEMICAL JOURNAL

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

(2012) Jonathan N. Pruneda et al.   MOLECULAR CELL

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex

(2012) Kristina Uzunova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

(2012) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and purification of E. coli BirA biotin ligase for in vitro biotinylation

(2012) Yifeng Li et al.   PROTEIN EXPRESSION AND PURIFICATION

The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings

(2012) Jun He et al.   STRUCTURE

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

UCSF Chimera, MODELLER, and IMP: An integrated modeling system

(2011) Zheng Yang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate

(2011) Anjanabha Saha et al.   MOLECULAR CELL

Structural basis for the subunit assembly of the anaphase-promoting complex

(2011) Anne Schreiber et al.   NATURE

How APC/C–Cdc20 changes its substrate specificity in mitosis

(2011) Daisuke Izawa et al.   NATURE CELL BIOLOGY

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

(2011) Matthew F Calabrese et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27

(2010) Ziguo Zhang et al.   EMBO JOURNAL

Molecular Structure of the N-terminal Domain of the APC/C Subunit Cdc27 Reveals a Homo-dimeric Tetratricopeptide Repeat Architecture

(2010) Ziguo Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor

(2010) Paula C. A. da Fonseca et al.   NATURE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1

(2010) Bettina A Buschhorn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

(2010) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins

(2010) J. R. A. Hutchins et al.   SCIENCE

Molecular dynamics flexible fitting: A practical guide to combine cryo-electron microscopy and X-ray crystallography

(2009) Leonardo G. Trabuco et al.   METHODS

Analysis of Activator-Binding Sites on the APC/C Supports a Cooperative Substrate-Binding Mechanism

(2009) Mary E. Matyskiela et al.   MOLECULAR CELL

Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78

(2009) Ranabir Das et al.   MOLECULAR CELL

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure

(2009) Jing Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of a physiological E2 module for the human anaphase-promoting complex

(2009) A. Williamson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex

(2009) F. Herzog et al.   SCIENCE

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Crystal Structure of the N-terminal Domain of Anaphase-promoting Complex Subunit 7

(2008) Dohyun Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC

(2008) Matthew K. Summers et al.   MOLECULAR CELL

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

(2008) Yuu Kimata et al.   MOLECULAR CELL

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL