Article
Biochemistry & Molecular Biology
Moon Jong Kim, Christopher Cervantes, Youn-Sang Jung, Xiaoshan Zhang, Jie Zhang, Sung Ho Lee, Sohee Jun, Larisa Litovchick, Wenqi Wang, Junjie Chen, Bingliang Fang, Jae-Il Park
Summary: PAF drives cell quiescence exit to promote lung tumorigenesis by remodeling the DREAM complex. Its depletion induces cell quiescence in lung adenocarcinoma cells and inhibits tumor growth, suggesting the PAF-DREAM axis as a potential therapeutic target in lung cancer.
Article
Cell Biology
Csenge Gal, Francesco Nicola Carelli, Alex Appert, Chiara Cerrato, Ni Huang, Yan Dong, Jane Murphy, Andrea Frapporti, Julie Ahringer
Summary: THAP domain proteins LIN-15B and LIN-36 repress distinct cell-cycle and germline-specific target genes through different mechanisms, regulating DREAM complex binding at gene body and promoter levels.
Article
Biology
Lucas Lang, Aladar Pettko-Szandtner, Hasibe Tuncay Elbasi, Hirotomo Takatsuka, Yuji Nomoto, Ahmad Zaki, Stefan Dorokhov, Geert De Jaeger, Dominique Eeckhout, Masaki Ito, Zoltan Magyar, Laszlo Bogre, Maren Heese, Arp Schnittger
Summary: DNA damage can reduce plant growth and cell proliferation, and the interaction among RBR1, NAC044, and DREAM components play important roles in mediating growth arrest after DNA damage in plants. Multiple DREAM complexes exist and work together with NAC044 to regulate the response to DNA damage.
LIFE SCIENCE ALLIANCE
(2021)
Article
Cell Biology
Glynnis A. Garry, Svetlana Bezprozvannaya, Kenian Chen, Huanyu Zhou, Hisayuki Hashimoto, Maria Gabriela Morales, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson
Summary: The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to increase accessibility to core cardiac transcription factors, facilitating direct cardiac reprogramming.
NATURE CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yinzhu Hou, Tieliang Gan, Tiantian Fang, Yao Zhao, Qun Luo, Xingkai Liu, Luyu Qi, Yanyan Zhang, Feifei Jia, Juanjuan Han, Shumu Li, Shijun Wang, Fuyi Wang
Summary: Using MS proteomics strategy, this study uncovered the complex regulation of gene expression by PDS in HeLa cancer cells, and also revealed the impact of PDS on cell cycle regulation. Furthermore, the downregulation of PC4 was found to enhance the cytotoxicity of a platinum anticancer drug towards HeLa cells.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Thomas Tischer, Jing Yang, David Barford
Summary: The control of protein abundance is critical during mitosis, and this study reveals that the APC/C not only regulates mitotic progression, but also plays a role in spindle assembly through its interaction with Cep152.
JOURNAL OF CELL SCIENCE
(2022)
Article
Oncology
Michael D. Nyquist, Ilsa M. Coleman, Jared M. Lucas, Dapei Li, Brian Hanratty, Hannah Meade, Elahe A. Mostaghel, Stephen R. Plymate, Eva Corey, Michael C. Haffner, Peter S. Nelson
Summary: The androgen receptor pathway plays important roles in cell survival in prostate epithelium. High dose androgen treatment can suppress the growth of prostate cancer by negatively regulating MYC and the DREAM complex, leading to downregulation of E2F1 signaling. The integrity of MYC signaling and DREAM complex assembly may determine the responses of prostate cancer patients to high dose androgen treatment.
Review
Endocrinology & Metabolism
Siresha Bathina, Reina Armamento-Villareal
Summary: Fractures associated with Type 2 diabetes (T2DM) are a public health concern in an obese and aging population. Patients with T2DM have normal or better bone mineral density but are at a higher risk for fractures. The main issue in T2DM is a reduction in bone formation due to dysfunction in osteoblast differentiation and survival. Obesity and T2DM are also associated with increased adipogenesis, potentially at the expense of reduced osteogenesis and myogenesis. Understanding the complex mechanisms involved in bone pathophysiology in obesity and T2DM is important for developing pharmacological targets to improve bone health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Rosaria Dello Stritto, Nina Vojtassakova, Maria Velkova, Patricia Hamminger, Patricia Ulm, Verena Jantsch
Summary: Homologous recombination is an important DNA repair pathway used in the gonad, and the BTR complex plays a critical role in this process. The ZnF domain of topoisomerase 3 cooperates with the RMI1 homolog RMH-2 to stabilize the association of the complex with recombination intermediates and prevent recombination between heterologous DNA sequences.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Peidong Li, Jing Wen, Xiru Ren, Yu Zhou, Yuan Xue, Zaihua Yan, Shengjie Li, Hongpeng Tian, Xue-Gui Tang, Guang-Jun Zhang
Summary: The study found that NCAPG is upregulated in CRC, associated with clinical characteristics, independently related to poor survival. NCAPG regulates CRC cell proliferation by promoting growth and inhibiting apoptosis, while miR-23b-3p negatively regulates NCAPG expression. This suggests that the miR-23b-3p/NCAPG/PI3K/AKT signaling axis may play an important role in CRC carcinogenesis.
Review
Pharmacology & Pharmacy
Lena Lau, Gregory David
EXPERT OPINION ON THERAPEUTIC TARGETS
(2019)
Article
Cell Biology
Timothy Nacarelli, Lena Lau, Takeshi Fukumoto, Joseph Zundell, Nail Fatkhutdinov, Shuai Wu, Katherine M. Aird, Osamu Iwasaki, Andrew V. Kossenkov, David Schultz, Ken-ichi Noma, Joseph A. Baur, Zachary Schug, Hsin-Yao Tang, David W. Speicher, Gregory David, Rugang Zhang
NATURE CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Lena Lau, Angelo Porciuncula, Alex Yu, Yoichiro Iwakura, Gregory David
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Article
Cell & Tissue Engineering
Christina C. Spevak, Harold K. Elias, Lavanya Kannan, Mohamed A. E. Ali, Gaelle H. Martin, Shanmugapriya Selvaraj, William S. Eng, Amanda Ernlund, Vinagolu K. Rajasekhar, Carolien M. Woolthuis, Guangjie Zhao, Caryn J. Ha, Robert J. Schneider, Christopher Y. Park
Article
Cell Biology
Boxiao Ding, Fang Yuan, Priyadarshan K. Damle, Larisa Litovchick, Ronny Drapkin, Steven R. Grossman
CELL DEATH & DISEASE
(2020)
Article
Critical Care Medicine
Changfu Yao, Xiangrong Guan, Gianni Carraro, Tanyalak Parimon, Xue Liu, Guanling Huang, Apoorva Mulay, Harmik J. Soukiasian, Gregory David, Stephen S. Weigt, John A. Belperio, Peter Chen, Dianhua Jiang, Paul W. Noble, Barry R. Stripp
Summary: The study demonstrates that senescence of AT2 cells is sufficient to drive progressive pulmonary fibrosis, and interventions targeting p53 activation or senescence can block fibrogenesis. Early attenuation of senescence-related pathways and elimination of senescent cells are promising therapeutic approaches to prevent pulmonary fibrosis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Editorial Material
Education, Scientific Disciplines
Aram S. Modrek, Naoko Tanese, Dimitris G. Placantonakis, Erik P. Sulman, Rafael Rivera, Kevin L. Du, Naamit K. Gerber, Gregory David, Mitchell Chesler, Mark R. Philips, Joan Cangiarella
Summary: The Accelerated MD-PhD-Residency Pathway at New York University Grossman School of Medicine was established to address challenges in training physician-scientists. It aims to reduce training time and costs, provide research opportunities during residency, and foster strong collaborations to increase success rates. The program plans to track the success of trainees and hopes to serve as a model for other institutions to adopt similar pathways for MD-PhD students.
Editorial Material
Biochemistry & Molecular Biology
Rebecca L. Plessel, Gregory David
Article
Microbiology
Kristin H. Loomis, Susan K. Wu, Amanda Ernlund, Kristina Zudock, Allison Reno, Kianna Blount, David K. Karig
Summary: This study demonstrates that the microbiome on the skin tissue model significantly alters gene expression patterns, affecting genes involved in apoptosis, proliferation, and extracellular matrix regulation, among others. The microbiome treatment influences the thickness of the epidermal layer, reduces the number of actively proliferating cells, and increases filaggrin expression. It shows that a diverse skin microbiome has unique and pronounced effects on the host, more so than individual microbes.
Article
Oncology
Claire D. James, Siddharth Saini, Fatmata Sesay, Kevin Ko, Jessica Felthousen-Rusbasan, Audra N. Iness, Tara Nulton, Brad Windle, Mikhail G. Dozmorov, Iain M. Morgan, Larisa Litovchick
Summary: Human papillomaviruses, responsible for 5% of cancers, disrupt the DREAM complex in HPV positive cells, leading to increased expression of DREAM target genes. The mutant DREAM component LIN52 S20C can compete with E7 and partially restore DREAM complex formation, inhibiting the growth of HPV positive cells. Restoring the DREAM complex in HPV positive cancers could be a novel therapeutic approach.
Article
Cell Biology
Amanda W. Ernlund, Lauren T. Moffatt, Collin M. Timm, Kristina K. Zudock, Craig W. Howser, Kianna M. Blount, Abdulnaser Alkhalil, Jeffrey W. Shupp, David K. Karig
Summary: The research found that washing of venous leg ulcer wounds does not consistently change the microbiome diversity, but does lead to consistent changes in microbiome composition, including a decrease in the relative abundance of the most highly represented genera in each patient cluster. This novel finding could potentially be informative for future guided therapy strategies.
WOUND REPAIR AND REGENERATION
(2021)
Article
Medicine, Research & Experimental
Peter M. Thielen, Shirlee Wohl, Thomas Mehoke, Srividya Ramakrishnan, Melanie Kirsche, Oluwaseun Falade-Nwulia, Nidia S. Trovao, Amanda Ernlund, Craig Howser, Norah Sadowski, C. Paul Morris, Mark Hopkins, Matthew Schwartz, Yunfan Fan, Victoria Gniazdowski, Justin Lessler, Lauren Sauer, Michael C. Schatz, Jared D. Evans, Stuart C. Ray, Winston Timp, Heba H. Mostafa
Summary: The early COVID-19 pandemic saw rapid global spread, with over 2500 cases reported in Maryland and Washington, DC within just 3 weeks. Genomic sequencing of samples from the region revealed that the diversity of SARS-CoV-2 in the area was comparable to global levels, indicating multiple introductions into the region. This interconnectedness likely contributed to the challenges in controlling local spread of the virus.
Article
Medicine, Research & Experimental
Margaret E. Maes, Gabriele M. Wogenstein, Gloria Colombo, Raquel Casado-Polanco, Sandra Siegert
Summary: This study demonstrates that modifying the AAV6 capsid can enhance microglial transduction in the outer plexiform layer, validated in the retina as a model system, and highlights the significant influence of environmental conditions on microglial transduction efficiency.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
Article
Genetics & Heredity
Robert Player, Kathleen Verratti, Andrea Staab, Ellen Forsyth, Amanda Ernlund, Mihir S. Joshi, Rebecca Dunning, David Rozak, Sarah Grady, Bruce Goodwin, Shanmuga Sozhamannan
Summary: An optimized targeted genomic sequencing method using Oxford Nanopore Technology (ONT) was developed and compared with PCR for biodefense and biosurveillance applications. The study identified the best ONT library preparation method and integrated it into a real-time amplicon sequence analysis workflow. The results showed that the ONT method provided faster and more accurate detection of target organisms compared to PCR-based methods.
Article
Neurosciences
Ivan Castela, Raquel Casado-Polanco, Yaiza Van-Waes Rubio, Joaquim Alves da Silva, Raquel Marquez, Beatriz Pro, Rosario Moratalla, Peter Redgrave, Rui M. Costa, Jose Obeso, Ledia F. Hernandez
Summary: This study used a rodent model to investigate the striatal outflow circuitry responsible for L-DOPA-induced dyskinesias (LIDs) in Parkinson's disease (PD). The activation of the indirect pathway was found to effectively suppress LIDs, highlighting the importance of maintaining an equilibrium in the activity of both striatal pathways for normal movement. These findings provide insights into the intrinsic mechanisms and potential therapeutic targets for suppressing LIDs in PD patients.
NEUROBIOLOGY OF DISEASE
(2023)
