Sensing, signaling and surviving mitochondrial stress

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

(2021) Sandra Backes et al.   Cell Reports

From TOM to the TIM23 complex – handing over of a precursor

(2020) Sylvie Callegari et al.   BIOLOGICAL CHEMISTRY

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

(2020) Xiaoyan Guo et al.   NATURE

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

(2020) Evelyn Fessler et al.   NATURE

How the Mitoprotein-Induced Stress Response Safeguards the Cytosol: A Unified View

(2020) Felix Boos et al.   TRENDS IN CELL BIOLOGY

Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

(2020) Lan Wang et al.   eLife

CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy

(2020) David Pla‐Martín et al.   EMBO JOURNAL

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

(2020) Dae-Sung Hwangbo et al.   Nutrients

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

(2020) Eran Mick et al.   eLife

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

(2020) Guo Chen et al.   Frontiers in Cell and Developmental Biology

Folding the Mitochondrial UPR into the Integrated Stress Response

(2020) Nadine S. Anderson et al.   TRENDS IN CELL BIOLOGY

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

(2020) Stefan Reich et al.   Nature Communications

Mitochondrial Protein Quality Control Mechanisms

(2020) Pooja Jadiya et al.   Genes

NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level

(2020) Di Zhu et al.   Science Advances

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

(2020) Emma V Rusilowicz-Jones et al.   Life Science Alliance

The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress

(2020) Stephen E. Girardin et al.   FEBS Journal

Mitophagy pathways in health and disease

(2020) Samuel A. Killackey et al.   JOURNAL OF CELL BIOLOGY

Quality control of the mitochondrial proteome

(2020) Jiyao Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity

(2020) Li-Wa Shao et al.   Nature Communications

A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPR

(2020) Siraje Arif Mahmud et al.   PLoS Pathogens

Mitochondria-ER Tethering in Neurodegenerative Diseases

(2020) Reza Raeisossadati et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy

(2019) Tomokazu Murakawa et al.   Cell Reports

PKR: A Kinase to Remember

(2019) Shunit Gal-Ben-Ari et al.   Frontiers in Molecular Neuroscience

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

(2019) Hai Hu et al.   Frontiers in Immunology

Activation of GCN2 by the ribosomal P-stalk

(2019) Alison J. Inglis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

(2019) Felix Boos et al.   NATURE CELL BIOLOGY

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

(2019) Shiori Sekine et al.   MOLECULAR CELL

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol

(2019) Yaxin Liu et al.   MOLECULAR BIOLOGY OF THE CELL

The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition

(2019) Albert Perez-Riba et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations

(2019) Nidhi Jatana et al.   Autophagy

Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL

(2019) Fumika Koyano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

(2019) Ioannis Smyrnias et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

Mechanisms and functions of ribosome-associated protein quality control

(2019) Claudio A. P. Joazeiro   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CAT tails drive degradation of stalled polypeptides on and off the ribosome

(2019) Cole S. Sitron et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis

(2019) Sashaina E. Fanibunda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

(2019) Chaojun Yan et al.   Autophagy

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

(2019) Mena Abdel-Nour et al.   SCIENCE

Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity

(2019) Jianfeng Lan et al.   Cell Reports

The Hap Complex in Yeasts: Structure, Assembly Mode, and Gene Regulation

(2019) Yinhe Mao et al.   Frontiers in Microbiology

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy

(2019) Flavie Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt

(2019) Stéphane G. Rolland et al.   Cell Reports

UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor

(2019) Megan C. Kopp et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts

(2019) Rajat Puri et al.   Nature Communications

Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells

(2019) Amita Daverey et al.   Scientific Reports

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

A Futile Battle? Protein Quality Control and the Stress of Aging

(2018) Ryo Higuchi-Sanabria et al.   DEVELOPMENTAL CELL

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

(2018) Nadee Nissanka et al.   FEBS LETTERS

The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization

(2018) Peng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics

(2018) Alban Ordureau et al.   MOLECULAR CELL

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

(2018) Alisa F. Zyryanova et al.   SCIENCE

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

(2018) Jordan C. Tsai et al.   SCIENCE

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

(2018) Jeremy D. Grevet et al.   SCIENCE

Ablation of the stress protease OMA1 protects against heart failure in mice

(2018) Rebeca Acin-Perez et al.   Science Translational Medicine

Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy

(2018) J.G.C. Peeters et al.   Autophagy

The different axes of the mammalian mitochondrial unfolded protein response

(2018) Christian Münch   BMC BIOLOGY

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities

(2018) Ligia Akemi Kiyuna et al.   FREE RADICAL BIOLOGY AND MEDICINE

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

(2018) Anthea Di Rita et al.   Nature Communications

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

(2018) Hao Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

(2018) Jae Kyu Ryu et al.   NATURE IMMUNOLOGY

Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis

(2018) Łukasz Opaliński et al.   Cell Reports

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs

(2017) Désirée Schatton et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux

(2017) Laura Pontano Vaites et al.   MOLECULAR AND CELLULAR BIOLOGY

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome

(2017) Daniela Valenti et al.   NEUROPHARMACOLOGY

CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides

(2017) Kamena K. Kostova et al.   SCIENCE

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease

(2017) Brianada Koentjoro et al.   Scientific Reports

Exocytosis and Spreading of Normal and Aberrant α-Synuclein

(2016) Evangelia Emmanouilidou et al.   BRAIN PATHOLOGY

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover

(2016) Daniel Poveda-Huertes et al.   CELL AND TISSUE RESEARCH

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

(2016) Bryan L. Gitschlag et al.   Cell Metabolism

Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response

(2016) Li-Wa Shao et al.   CELL RESEARCH

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria

(2016) Anne Korwitz et al.   JOURNAL OF CELL BIOLOGY

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process

(2016) Giovanna Cenini et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

(2016) Christian Münch et al.   NATURE

Failure of RQC machinery causes protein aggregation and proteotoxic stress

(2016) Young-Jun Choe et al.   NATURE

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

(2016) Jenni M. Lehtonen et al.   NEUROLOGY

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Characterization of the targeting signal in mitochondrial β-barrel proteins

(2016) Tobias Jores et al.   Nature Communications

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress

(2016) T. Kelly Rainbolt et al.   Cell Reports

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Integrated stress response of vertebrates is regulated by four eIF2α kinases

(2016) Shusuke Taniuchi et al.   Scientific Reports

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

(2015) Shuichi Yatsuga et al.   ANNALS OF NEUROLOGY

The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway

(2015) Feng Gao et al.   HUMAN MOLECULAR GENETICS

Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins

(2015) Justin J. Crowder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated ubiquitin chain is the genuine Parkin receptor

(2015) Kei Okatsu et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability

(2015) Iryna Bohovych et al.   Scientific Reports

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation

(2014) Dirk Mossmann et al.   Cell Metabolism

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

(2014) M. J. Baker et al.   EMBO JOURNAL

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage

(2014) K. Zhang et al.   EMBO REPORTS

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins

(2014) Jie Gao et al.   JOURNAL OF CELL BIOLOGY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Proteotoxicity: An underappreciated pathology in cardiac disease

(2014) Marco Sandri et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

(2014) V. Okreglak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force

(2013) Ketan Malhotra et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

(2013) Vicky Wang-Wei Tsai et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

(2013) Eva D. Runkel et al.   PLoS Genetics

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

(2013) Karl Grenier et al.   Frontiers in Neurology

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

(2012) Pedro M Quirós et al.   EMBO JOURNAL

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes

(2012) Katrin Krumpe et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling

(2012) Alice C. Newman et al.   PLoS One

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins

(2011) Thomas Becker et al.   JOURNAL OF CELL BIOLOGY

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization

(2011) F.-Nora Vögtle et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction

(2010) Tanenobu Harada et al.   APOPTOSIS

Multiple pathways in the integration of proteins into the mitochondrial outer membrane

(2010) Jovana Dukanovic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Protein translocation across the ER membrane

(2010) Richard Zimmermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

(2010) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

(2009) Joshua R. Veatch et al.   CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

A novel intermembrane space–targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding

(2009) Dionisia P. Sideris et al.   JOURNAL OF CELL BIOLOGY

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

(2009) Dejana Mokranjac et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of the Signal Directing Tim9 and Tim10 into the Intermembrane Space of Mitochondria

(2009) Dusanka Milenkovic et al.   MOLECULAR BIOLOGY OF THE CELL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

(2009) Heather P. Harding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disulfide Formation in the ER and Mitochondria: Two Solutions to a Common Process

(2009) J. Riemer et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Fluorescence Mapping of Mitochondrial TIM23 Complex Reveals a Water-Facing, Substrate-Interacting Helix Surface

(2008) Nathan N. Alder et al.   CELL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitophagy in Yeast Occurs through a Selective Mechanism

(2008) Tomotake Kanki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of tail-anchored proteins into the mitochondrial outer membrane does not require any known import components

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