Mechanisms and functions of ribosome-associated protein quality control

Mechanistic insights into ER-associated protein degradation

(2018) Xudong Wu et al.   CURRENT OPINION IN CELL BIOLOGY

Polylysine is a Proteostasis Network-Engaging Structural Determinant

(2018) Wei-Han Lang et al.   JOURNAL OF PROTEOME RESEARCH

Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches

(2018) Nathan Zuzow et al.   MOLECULAR BIOLOGY OF THE CELL

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

(2018) Kuan-Chuan Pao et al.   NATURE

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roadblocks and resolutions in eukaryotic translation

(2018) Anthony P. Schuller et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vms1p is a release factor for the ribosome-associated quality control complex

(2018) Olga Zurita Rendón et al.   Nature Communications

Nonsense mRNA suppression via nonstop decay

(2018) Joshua A Arribere et al.   eLife

Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1

(2018) Kazushige Kuroha et al.   MOLECULAR CELL

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes

(2018) Rati Verma et al.   NATURE

Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis

(2017) Éva Kevei et al.   FEBS LETTERS

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregation

(2017) Quentin Defenouillère et al.   MOLECULAR BIOLOGY OF THE CELL

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination

(2017) Szymon Juszkiewicz et al.   MOLECULAR CELL

In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome

(2017) Hikaru Tsuchiya et al.   MOLECULAR CELL

Ribosome Collision Is Critical for Quality Control during No-Go Decay

(2017) Carrie L. Simms et al.   MOLECULAR CELL

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation

(2017) Elayanambi Sundaramoorthy et al.   MOLECULAR CELL

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control

(2017) Anshuk Sarkar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome pausing, arrest and rescue in bacteria and eukaryotes

(2017) Allen R. Buskirk et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation

(2017) Cole S. Sitron et al.   RNA

CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides

(2017) Kamena K. Kostova et al.   SCIENCE

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

(2017) Aitor Garzia et al.   Nature Communications

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control

(2017) Anshuk Sarkar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing

(2017) Beatriz A Osuna et al.   eLife

Protein aggregation as a mechanism of adaptive cellular responses

(2016) Juha Saarikangas et al.   CURRENT GENETICS

Protein quality control in the nucleus

(2016) Ramon D Jones et al.   CURRENT OPINION IN CELL BIOLOGY

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits

(2016) Quentin Defenouillère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase

(2016) Annika Weber et al.   MOLECULAR CELL

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Failure of RQC machinery causes protein aggregation and proteotoxic stress

(2016) Young-Jun Choe et al.   NATURE

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct types of translation termination generate substrates for ribosome-associated quality control

(2016) Natalia Shcherbik et al.   NUCLEIC ACIDS RESEARCH

Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits

(2016) Selom K. Doamekpor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution

(2016) Tarek Hilal et al.   Nature Communications

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

(2016) Ryo Yonashiro et al.   eLife

The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation

(2016) Yue Xu et al.   Cell Discovery

Ubiquitination of newly synthesized proteins at the ribosome

(2015) Feng Wang et al.   BIOCHIMIE

Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins

(2015) Justin J. Crowder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surviving protein quality control catastrophes - from cells to organisms

(2015) K. Schneider et al.   JOURNAL OF CELL SCIENCE

Spatially Organized Aggregation of Misfolded Proteins as Cellular Stress Defense Strategy

(2015) Stephanie B.M. Miller et al.   JOURNAL OF MOLECULAR BIOLOGY

The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon

(2015) Karina von der Malsburg et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and Assembly Pathway of the Ribosome Quality Control Complex

(2015) Sichen Shao et al.   MOLECULAR CELL

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains

(2015) P. S. Shen et al.   SCIENCE

Translational control by lysine-encoding A-rich sequences

(2015) L. L. Arthur et al.   Science Advances

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

Atypical Ubiquitylation in Yeast Targets Lysine-less Asi2 for Proteasomal Degradation

(2014) Mirta Boban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy

(2014) Batool Ossareh-Nazari et al.   JOURNAL OF CELL BIOLOGY

Reconstitution of a Minimal Ribosome-Associated Ubiquitination Pathway with Purified Factors

(2014) Sichen Shao et al.   MOLECULAR CELL

Protein quality control at the inner nuclear membrane

(2014) Anton Khmelinskii et al.   NATURE

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

(2014) Robert K. McGinty et al.   NATURE

Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex

(2014) Dmitry Lyumkis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality control of inner nuclear membrane proteins by the Asi complex

(2014) O. Foresti et al.   SCIENCE

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

Overcoming stalled translation in human mitochondria

(2014) Maria T. Wesolowska et al.   Frontiers in Microbiology

Arrest Peptides:Cis-Acting Modulators of Translation

(2013) Koreaki Ito et al.   Annual Review of Biochemistry

Non-canonical ubiquitylation: Mechanisms and consequences

(2013) Gary S. McDowell et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Listerin-Dependent Nascent Protein Ubiquitination Relies on Ribosome Subunit Dissociation

(2013) Sichen Shao et al.   MOLECULAR CELL

Principles of Cotranslational Ubiquitination and Quality Control at the Ribosome

(2013) Stefanie Duttler et al.   MOLECULAR CELL

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase

(2013) D. Lyumkis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

(2013) Q. Defenouillere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

Non-canonical ubiquitin-based signals for proteasomal degradation

(2012) Y. Kravtsova-Ivantsiv et al.   JOURNAL OF CELL SCIENCE

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Surveillance pathways rescuing eukaryotic ribosomes lost in translation

(2012) Marc Graille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Translation drives mRNA quality control

(2012) Christopher J Shoemaker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Roles of Dom34:Hbs1 in Nonstop Protein Clearance from Translocators for Normal Organelle Protein Influx

(2012) Toshiaki Izawa et al.   Cell Reports

Confinement to Organelle-Associated Inclusion Structures Mediates Asymmetric Inheritance of Aggregated Protein in Budding Yeast

(2012) Rachel Spokoini et al.   Cell Reports

The Yeast Ubr1 Ubiquitin Ligase Participates in a Prominent Pathway That Targets Cytosolic Thermosensitive Mutants for Degradation

(2012) Farzin Khosrow-Khavar et al.   G3-Genes Genomes Genetics

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

(2011) Eric S. Fischer et al.   CELL

Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes

(2011) Vera P Pisareva et al.   EMBO JOURNAL

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast

(2011) C. J. Shoemaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine Residues in the Cytosolic Tail of the T-cell Antigen Receptor α-Chain Mediate Ubiquitination and Endoplasmic Reticulum-associated Degradation of the Unassembled Protein

(2010) Shuhei Ishikura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

(2010) Nadinath B. Nillegoda et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitylation of an ERAD Substrate Occurs on Multiple Types of Amino Acids

(2010) Yuichiro Shimizu et al.   MOLECULAR CELL

Role of a ribosome-associated E3 ubiquitin ligase in protein quality control

(2010) Mario H. Bengtson et al.   NATURE

Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay

(2010) C. J. Shoemaker et al.   SCIENCE

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration

(2009) J. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1

(2008) Frederik Eisele et al.   FEBS LETTERS

Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates

(2008) Jianli Lu et al.   JOURNAL OF MOLECULAR BIOLOGY