A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPR

A Persistence Detector for Metabolic Network Rewiring in an Animal

(2019) Jote T. Bulcha et al.   Cell Reports

Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia

(2018) Tom S. Chan et al.   PLoS One

Boosted TCA cycle enhances survival of zebrafish to Vibrio alginolyticus infection

(2018) Man-Jun Yang et al.   Virulence

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Branched Chain Amino Acids

(2018) Michael Neinast et al.   Annual Review of Physiology

CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans

(2018) Vinci Au et al.   G3-Genes Genomes Genetics

The mitochondrial unfolded protein response: Signaling from the powerhouse

(2017) Mohammed A. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxicity of 2,6-dichloro-1,4-benzoquinone and five regulated drinking water disinfection by-products for the Caenorhabditis elegans nematode

(2017) Yu-Ting Zuo et al.   JOURNAL OF HAZARDOUS MATERIALS

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

(2017) Tao Long et al.   NATURE GENETICS

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes

(2017) Adi Haber et al.   PLoS Pathogens

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Proline Catabolism Modulates Innate Immunity in Caenorhabditis elegans

(2016) Haiqing Tang et al.   Cell Reports

Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans

(2016) Emma Watson et al.   eLife

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

(2015) Johannes Mansfeld et al.   Nature Communications

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Behavioral avoidance of pathogenic bacteria by Caenorhabditis elegans

(2014) Joshua D. Meisel et al.   TRENDS IN IMMUNOLOGY

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death

(2013) Natalia V. Kirienko et al.   Cell Host & Microbe

Host Translational Inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an Immune Response in Caenorhabditis elegans

(2012) Deborah L. McEwan et al.   Cell Host & Microbe

C. elegans Detects Pathogen-Induced Translational Inhibition to Activate Immune Signaling

(2012) Tiffany L. Dunbar et al.   Cell Host & Microbe

Enhanced Energy Metabolism Contributes to the Extended Life Span of Calorie-restrictedCaenorhabditis elegans

(2012) Yiyuan Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Genome-Wide Identification of Pseudomonas aeruginosa Virulence-Related Genes Using a Caenorhabditis elegans Infection Model

(2012) Rhonda L. Feinbaum et al.   PLoS Pathogens

Mitochondria in innate immunity

(2011) Damien Arnoult et al.   EMBO REPORTS

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

An essential role for XBP-1 in host protection against immune activation in C. elegans

(2010) Claire E. Richardson et al.   NATURE

bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans

(2010) K. A. Estes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization of GC/MS and LC/MS metabolomics data into chemical libraries

(2010) Corey D DeHaven et al.   Journal of Cheminformatics

Distinct Pathogenesis and Host Responses during Infection of C. elegans by P. aeruginosa and S. aureus

(2010) Javier E. Irazoqui et al.   PLoS Pathogens

FadD from Pseudomonas putida CA-3 Is a True Long-Chain Fatty Acyl Coenzyme A Synthetase That Activates Phenylalkanoic and Alkanoic Acids

(2009) A. R. Hume et al.   JOURNAL OF BACTERIOLOGY