Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination

(2018) Nathanael J Lee et al.   BRAIN

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Blood will out: vascular contributions to Alzheimer’s disease

(2018) Sidney Strickland   JOURNAL OF CLINICAL INVESTIGATION

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals

(2018) Jennifer S. Rabin et al.   JAMA Neurology

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

(2017) Mark A. Petersen et al.   NEURON

NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

(2016) J Haslund-Vinding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3

(2016) Maria Risager Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly

(2015) Prashanthi Vemuri et al.   BRAIN

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration

(2015) Marta Cortes-Canteli et al.   NEUROBIOLOGY OF AGING

WikiPathways: capturing the full diversity of pathway knowledge

(2015) Martina Kutmon et al.   NUCLEIC ACIDS RESEARCH

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

(2014) Cornelia Schuh et al.   ACTA NEUROPATHOLOGICA

Factor XIII activity mediates red blood cell retention in venous thrombi

(2014) Maria M. Aleman et al.   JOURNAL OF CLINICAL INVESTIGATION

Early detection of thrombin activity in neuroinflammatory disease

(2013) Dimitrios Davalos et al.   ANNALS OF NEUROLOGY

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Assessing bleeding risk in patients taking anticoagulants

(2013) Marwa Shoeb et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer’s disease

(2011) Hans Lassmann   JOURNAL OF NEURAL TRANSMISSION

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrinogen as a key regulator of inflammation in disease

(2011) Dimitrios Davalos et al.   Seminars in Immunopathology

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE