The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria

(2018) Matthew T. Sorbara et al.   Cell Host & Microbe

The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking

(2018) Wael Bahnan et al.   INFECTION AND IMMUNITY

Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway

(2017) Ryan G. Gaudet et al.   Cell Reports

NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation

(2016) Ivan Tattoli et al.   Cell Reports

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?

(2016) Abid Oueslati   Journal of Parkinsons Disease

Intracellular Bacterial Pathogens Trigger the Formation of U Small Nuclear RNA Bodies (U Bodies) through Metabolic Stress Induction

(2015) Jessica Tsalikis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor signalling through macromolecular protein complexes

(2015) Clare E. Bryant et al.   MOLECULAR IMMUNOLOGY

Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

(2015) R. G. Gaudet et al.   SCIENCE

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?

(2014) Jean Celli et al.   NATURE REVIEWS MICROBIOLOGY

Listeriaphospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures

(2013) Ivan Tattoli et al.   EMBO JOURNAL

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

(2013) Matthew T. Sorbara et al.   IMMUNITY

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program

(2012) Ivan Tattoli et al.   Cell Host & Microbe

Folding and misfolding of alpha-synuclein on membranes

(2011) Igor Dikiy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

(2011) Kaoru Geddes et al.   NATURE MEDICINE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

pH-dependent Internalization of Muramyl Peptides from Early Endosomes Enables Nod1 and Nod2 Signaling

(2009) Jooeun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase

(2008) Azmi Yerlikaya et al.   BIOCHEMICAL JOURNAL

HspB8 Participates in Protein Quality Control by a Non-chaperone-like Mechanism That Requires eIF2α Phosphorylation

(2008) Serena Carra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY