PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
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Title
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Authors
Keywords
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Journal
Open Biology
Volume 2, Issue 5, Pages 120080-120080
Publisher
The Royal Society
Online
2012-05-24
DOI
10.1098/rsob.120080
References
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Related references
Note: Only part of the references are listed.- Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
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- UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids
- (2011) Dawn M. Wenzel et al. NATURE
- Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations
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- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
- (2010) E. Ziviani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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- Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†
- (2009) Andreas Weihofen et al. BIOCHEMISTRY
- A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders
- (2009) Miratul M. K. Muqit et al. EMBO Molecular Medicine
- Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling
- (2009) D. Sha et al. HUMAN MOLECULAR GENETICS
- The PINK1/Parkin pathway: a mitochondrial quality control system?
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- PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
- (2008) Yongsung Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin
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- Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
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- Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
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- Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1
- (2007) Sho Takatori et al. NEUROSCIENCE LETTERS
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