Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

(2020) Yizhou Jiang et al.   Cells

Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults

(2020) Christopher R. Martens et al.   GeroScience

The Genetics of Aging: A Vertebrate Perspective

(2019) Param Priya Singh et al.   CELL

Early Time‐Restricted Feeding Reduces Appetite and Increases Fat Oxidation But Does Not Affect Energy Expenditure in Humans

(2019) Eric Ravussin et al.   Obesity

Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption

(2019) Jesús E. Villanueva et al.   Nature Communications

The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study

(2019) Stephen D. Anton et al.   Nutrients

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

(2019) Slaven Stekovic et al.   Cell Metabolism

Effects of Intermittent Fasting on Health, Aging, and Disease

(2019) Rafael de Cabo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

(2018) Elizabeth F. Sutton et al.   Cell Metabolism

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

(2018) James H. Catterson et al.   CURRENT BIOLOGY

Sirt4 is a mitochondrial regulator of metabolism and lifespan inDrosophila melanogaster

(2018) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals

(2018) Shunsuke Hoshino et al.   Aging-US

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

(2018) Cristina Giuliani et al.   CIRCULATION RESEARCH

Circadian clock genes’ overexpression in Drosophila alters diet impact on lifespan

(2018) Ilya Solovev et al.   BIOGERONTOLOGY

Caloric restriction and cellular senescence

(2018) Luigi Fontana et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Effects of Intermittent Versus Continuous Energy Intakes on Insulin Sensitivity and Metabolic Risk in Women with Overweight

(2018) Amy T. Hutchison et al.   Obesity

A time to fast

(2018) Andrea Di Francesco et al.   SCIENCE

Key proteins and pathways that regulate lifespan

(2017) Haihui Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies

(2017) Kelli L Vaughan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

(2017) Mark Lucanic et al.   Nature Communications

Drosophila as a model for ageing

(2017) Matthew D.W. Piper et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice

(2017) Hong-Mei Zhang et al.   Scientific Reports

The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster

(2016) Ozlem Altintas et al.   BMB Reports

A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction

(2016) Lei Hou et al.   Cell Metabolism

Deconstructing Dietary Restriction: A Case for Systems Approaches in Aging

(2016) Robin Yeo et al.   Cell Metabolism

Dietary Restriction Extends the Lifespan of Circadian Mutants tim and per

(2016) Matt Ulgherait et al.   Cell Metabolism

Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila

(2016) Subhash D. Katewa et al.   Cell Metabolism

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

Time-restricted feeding in young men performing resistance training: A randomized controlled trial

(2016) Grant M. Tinsley et al.   European Journal of Sport Science

Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone

(2016) J.R. Speakman et al.   EXPERIMENTAL GERONTOLOGY

Circadian clocks govern calorie restriction–mediated life span extension through BMAL1- and IGF-1-dependent mechanisms

(2016) Sonal A. Patel et al.   FASEB JOURNAL

Calorie restriction as an intervention in ageing

(2016) Guillermo López-Lluch et al.   JOURNAL OF PHYSIOLOGY-LONDON

A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity

(2016) Victoria A. Catenacci et al.   Obesity

Circadian rhythms identified inCaenorhabditis elegansby in vivo long-term monitoring of a bioluminescent reporter

(2016) María Eugenia Goya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Does Longer Lifespan Mean Longer Healthspan?

(2016) Malene Hansen et al.   TRENDS IN CELL BIOLOGY

Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms

(2016) Sonal A. Patel et al.   Scientific Reports

Human longevity: Genetics or Lifestyle? It takes two to tango

(2016) Giuseppe Passarino et al.   Immunity & Ageing

dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster

(2016) Johannes H. Bauer et al.   Aging-US

Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner

(2016) Rachel Whitaker et al.   Aging-US

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

(2015) S. Gill et al.   SCIENCE

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges

(2014) Amandine Chaix et al.   Cell Metabolism

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults

(2014) Kristin K. Hoddy et al.   Obesity

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

FLIC: High-Throughput, Continuous Analysis of Feeding Behaviors in Drosophila

(2014) Jennifer Ro et al.   PLoS One

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice

(2013) Evi M. Mercken et al.   AGING CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Metabolic regulation of Sirtuins upon fasting and the implication for cancer

(2013) Yueming Zhu et al.   CURRENT OPINION IN ONCOLOGY

Genetic variation in responses to dietary restriction — An unbiased tool for hypothesis testing

(2013) Chen-Yu Liao et al.   EXPERIMENTAL GERONTOLOGY

High carbohydrate–low protein consumption maximizes Drosophila lifespan

(2013) Kimberley D. Bruce et al.   EXPERIMENTAL GERONTOLOGY

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial

(2013) Krista A Varady et al.   Nutrition Journal

Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae

(2013) Ziyun Wu et al.   PLoS One

Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1

(2013) A. H. Ludewig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of intermittent fasting on metabolism in men

(2013) Fernanda Reis de Azevedo et al.   Revista da Associacao Medica Brasileira

A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

(2013) Masaharu Uno et al.   Cell Reports

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents

(2012) Carmen E. Perrone et al.   EXPERIMENTAL GERONTOLOGY

Dysfunctional Adiposity and the Risk of Prediabetes and Type 2 Diabetes in Obese Adults

(2012) Ian J. Neeland et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women

(2012) Monica C Klempel et al.   Nutrition Journal

The evolution of the TOR pathway and its role in cancer

(2012) E M Beauchamp et al.   ONCOGENE

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

(2012) Kushal Kr. Banerjee et al.   Cell Reports

C. elegansAMPKs promote survival and arrest germline development during nutrient stress

(2012) Masamitsu Fukuyama et al.   Biology Open

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

(2011) William R. Swindell   AGEING RESEARCH REVIEWS

The CALERIE Study: Design and methods of an innovative 25% caloric restriction intervention

(2011) Amy D. Rickman et al.   Contemporary Clinical Trials

Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials

(2011) Corby K. Martin et al.   JOURNAL OF APPLIED PHYSIOLOGY

The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: Results from the calerie trial of human caloric restriction

(2011) Mohsen Meydani et al.   Journal of Nutrition Health & Aging

A Method for High-Throughput Quantitative Analysis of Yeast Chronological Life Span

(2011) C. J. Murakami et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO

(2011) Gizem Rizki et al.   PLoS Genetics

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

(2010) M N Harvie et al.   INTERNATIONAL JOURNAL OF OBESITY

A circadian clock in Saccharomyces cerevisiae

(2010) Z. Eelderink-Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults

(2009) Krista A Varady et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila melanogaster

(2009) Richard C. Grandison et al.   PLoS One

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

(2009) Min Wei et al.   PLoS Genetics

A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species

(2009) Russell Bell et al.   PLoS Genetics

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

(2008) Maria E. Giannakou et al.   AGING CELL

Drosophila lifespan control by dietary restriction independent of insulin-like signaling

(2008) Kyung-Jin Min et al.   AGING CELL

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Regulation of Feeding and Metabolism by Neuronal and Peripheral Clocks in Drosophila

(2008) Kanyan Xu et al.   Cell Metabolism

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

(2008) Karyn L. Sheaffer et al.   CURRENT BIOLOGY

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

(2008) Sakiko Honjoh et al.   NATURE

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes

(2007) George L. Sutphin et al.   EXPERIMENTAL GERONTOLOGY