Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

(2018) Alisa F. Zyryanova et al.   SCIENCE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

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Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury

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Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

(2017) Joanna Obacz et al.   Science Signaling

Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

(2017) Joanna Obacz et al.   Science Signaling

The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance

(2017) Paolo Remondelli et al.   Frontiers in Molecular Neuroscience

Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response

(2016) Brian R. Hearn et al.   ChemMedChem

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of eukaryotic translation initiation factor 2B

(2016) Kazuhiro Kashiwagi et al.   NATURE

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

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The Phyre2 web portal for protein modeling, prediction and analysis

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Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2

(2015) Bernhard Kuhle et al.   NUCLEIC ACIDS RESEARCH

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

(2015) Y. Sekine et al.   SCIENCE

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

(2015) Carmela Sidrauski et al.   eLife

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Insights into the Architecture of the eIF2Bα/β/δ Regulatory Subcomplex

(2014) Andrew M. Bogorad et al.   BIOCHEMISTRY

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation

(2014) Noel C. Wortham et al.   FASEB JOURNAL

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core

(2014) Yuliya Gordiyenko et al.   Nature Communications

Co-Opting the Unfolded Protein Response to Elicit Olfactory Receptor Feedback

(2013) Ryan P. Dalton et al.   CELL

A Yeast Purification System for Human Translation Initiation Factors eIF2 and eIF2Bε and Their Use in the Diagnosis of CACH/VWM Disease

(2013) Rogerio A. de Almeida et al.   PLoS One

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

(2012) A. G. Hinnebusch et al.   Cold Spring Harbor Perspectives in Biology

Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

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MolProbity: all-atom structure validation for macromolecular crystallography

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Crystal Structure of the α Subunit of Human Translation Initiation Factor 2B

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