Parkinson’s disease: animal models and dopaminergic cell vulnerability
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Parkinson’s disease: animal models and dopaminergic cell vulnerability
Authors
Keywords
-
Journal
Frontiers in Neuroanatomy
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2014-12-15
DOI
10.3389/fnana.2014.00155
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease
- (2015) Ulrika Nordström et al. NEUROBIOLOGY OF DISEASE
- Long-Term Overexpression of Human Wild-Type and T240R Mutant Parkin in Rat Substantia Nigra Induces Progressive Dopaminergic Neurodegeneration
- (2014) Anne-Sophie Van Rompuy et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum
- (2014) C. Pifl et al. JOURNAL OF NEUROSCIENCE
- The prevalence of Parkinson's disease: A systematic review and meta-analysis
- (2014) Tamara Pringsheim et al. MOVEMENT DISORDERS
- Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice
- (2014) Marusela Oliveras-Salvá et al. NEUROBIOLOGY OF AGING
- Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration
- (2014) Elpida Tsika et al. NEUROBIOLOGY OF DISEASE
- Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications
- (2014) Iakov N. Rudenko et al. Neurotherapeutics
- Methamphetamine-induced neurotoxicity: the road to Parkinson’s disease
- (2014) Bessy Thrash et al. Pharmacological Reports
- Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice
- (2014) Gonzalo Sanchez et al. PLoS One
- Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo
- (2014) Kelly M. Lohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intramuscular injection of -synuclein induces CNS -synuclein pathology and a rapid-onset motor phenotype in transgenic mice
- (2014) A. N. Sacino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling
- (2014) V. A. Morais et al. SCIENCE
- Human adipose-Derived Mesenchymal Stem Cells Improve Motor Functions and are Neuroprotective in the 6-Hydroxydopamine-Rat Model for Parkinson’s Disease when Cultured in Monolayer Cultures but Suppress Hippocampal Neurogenesis and Hippocampal Memory Function when Cultured in Spheroids
- (2014) Jürgen Berg et al. Stem Cell Reviews and Reports
- Parkin and PINK1: much more than mitophagy
- (2014) Leslie A. Scarffe et al. TRENDS IN NEUROSCIENCES
- Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease
- (2014) Patricia M. Chege et al. Frontiers in Aging Neuroscience
- Mutations in theATP13A2Gene and Parkinsonism: A Preliminary Review
- (2014) Xinglong Yang et al. Biomed Research International
- A 6.4 Mb Duplication of the α-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism
- (2014) Eleanna Kara et al. JAMA Neurology
- The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution
- (2014) Nico P. Dantuma et al. Frontiers in Molecular Neuroscience
- Pathological alpha-synuclein propagates through neural networks
- (2014) Masami Masuda-Suzukake et al. Acta Neuropathologica Communications
- Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
- (2013) Ariadna Recasens et al. ANNALS OF NEUROLOGY
- Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease
- (2013) Sussy Bastías-Candia et al. ENVIRONMENTAL TOXICOLOGY
- Modeling dyskinesia in animal models of Parkinson disease
- (2013) Nicolas Morin et al. EXPERIMENTAL NEUROLOGY
- Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits
- (2013) Patrick J. Schultheis et al. HUMAN MOLECULAR GENETICS
- The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering
- (2013) D. Ottolini et al. HUMAN MOLECULAR GENETICS
- rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
- (2013) Marusela Oliveras-Salvá et al. Molecular Neurodegeneration
- Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease
- (2013) G Drui et al. MOLECULAR PSYCHIATRY
- MPTP-induced dopamine neuron degeneration and glia activation is potentiated in MDMA-pretreated mice
- (2013) Giulia Costa et al. MOVEMENT DISORDERS
- Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease
- (2013) Meghan R. Hennis et al. NEUROBIOLOGY OF DISEASE
- Reduced vesicular storage of catecholamines causes progressive degeneration in the locus ceruleus
- (2013) Tonya N. Taylor et al. NEUROPHARMACOLOGY
- Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations
- (2013) Andreas Puschmann PARKINSONISM & RELATED DISORDERS
- Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis
- (2013) Daniel Ness et al. PLoS One
- Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function
- (2013) Adam W. Oaks et al. PLoS One
- Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease
- (2013) Katrina L. Paumier et al. PLoS One
- Behavioral and Neurotransmitter Abnormalities in Mice Deficient for Parkin, DJ-1 and Superoxide Dismutase
- (2013) Meghan R. Hennis et al. PLoS One
- Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs
- (2013) Marco A. S. Baptista et al. PLoS One
- Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
- (2013) S. Janezic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
- (2013) E. S. Vincow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems
- (2013) Lars Brichta et al. TRENDS IN NEUROSCIENCES
- Modeling Parkinson's Disease in Primates: The MPTP Model
- (2013) G. Porras et al. Cold Spring Harbor Perspectives in Medicine
- A Guide to Neurotoxic Animal Models of Parkinson's Disease
- (2013) K. Tieu Cold Spring Harbor Perspectives in Medicine
- Drosophila as a Model to Study Mitochondrial Dysfunction in Parkinson's Disease
- (2013) M. Guo Cold Spring Harbor Perspectives in Medicine
- Rodent models of Parkinson's disease: beyond the motor symptomatology
- (2013) Filipa L. Campos et al. Frontiers in Behavioral Neuroscience
- Genetic animal models for evaluating the role of autophagy in etiopathogenesis of Parkinson disease
- (2012) M. Lenard Lachenmayer et al. Autophagy
- Late-onset Parkinsonism in NF B/c-Rel-deficient mice
- (2012) C. Baiguera et al. BRAIN
- (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD
- (2012) C-Y Chen et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
- (2012) Nicole Exner et al. EMBO JOURNAL
- ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons
- (2012) Alvin P. Joselin et al. HUMAN MOLECULAR GENETICS
- Temporal Expression of Mutant LRRK2 in Adult Rats Impairs Dopamine Reuptake
- (2012) Hongxia Zhou et al. International Journal of Biological Sciences
- Inactivation ofPink1Genein VivoSensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes,ParkinorDJ-1
- (2012) M. Emdadul Haque et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1
- (2012) X. Lin et al. JOURNAL OF NEUROSCIENCE
- Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of -Synuclein and LRRK2 in the Brain
- (2012) L. G. Friedman et al. JOURNAL OF NEUROSCIENCE
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: A PET, histological and biochemical study
- (2012) J. Blesa et al. NEUROBIOLOGY OF DISEASE
- Animal models of the non-motor features of Parkinson's disease
- (2012) Kimberly McDowell et al. NEUROBIOLOGY OF DISEASE
- Sonic Hedgehog Maintains Cellular and Neurochemical Homeostasis in the Adult Nigrostriatal Circuit
- (2012) Luis E. Gonzalez-Reyes et al. NEURON
- Pesticide exposure and Parkinson's disease: Epidemiological evidence of association
- (2012) Carmen Freire et al. NEUROTOXICOLOGY
- Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease
- (2012) M. W. C. Rousseaux et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease
- (2011) Kelly E. Glajch et al. BEHAVIOURAL BRAIN RESEARCH
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- Methamphetamine neurotoxicity decreases phasic, but not tonic, dopaminergic signaling in the rat striatum
- (2011) Christopher D. Howard et al. JOURNAL OF NEUROCHEMISTRY
- A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2
- (2011) J. Dusonchet et al. JOURNAL OF NEUROSCIENCE
- Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein
- (2011) Hoa A. Lam et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Age-related changes in dopamine signaling in Nurr1 deficient mice as a model of Parkinson's disease
- (2011) Lifen Zhang et al. NEUROBIOLOGY OF AGING
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease
- (2011) B.A. Morrow et al. NEUROSCIENCE
- Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice
- (2011) Ravi S. Akundi et al. PLoS One
- Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
- (2011) David Ramonet et al. PLoS One
- Low Concentrations of Methamphetamine Can Protect Dopaminergic Cells against a Larger Oxidative Stress Injury: Mechanistic Study
- (2011) Amina El Ayadi et al. PLoS One
- Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
- (2011) P. M. Rappold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Behavioral phenotyping of mouse models of Parkinson's disease
- (2010) Tonya N. Taylor et al. BEHAVIOURAL BRAIN RESEARCH
- Paraquat and Parkinson's disease
- (2010) C Berry et al. CELL DEATH AND DIFFERENTIATION
- Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S
- (2010) X. Li et al. JOURNAL OF NEUROSCIENCE
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An 18F-DOPA and 11C-DTBZ PET study
- (2010) Javier Blesa et al. NEUROBIOLOGY OF DISEASE
- Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
- (2010) H.L. Melrose et al. NEUROBIOLOGY OF DISEASE
- Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice
- (2010) B. Winner et al. NEUROBIOLOGY OF DISEASE
- Genetic Animal Models of Parkinson's Disease
- (2010) Ted M. Dawson et al. NEURON
- Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice
- (2010) Francisco Pan-Montojo et al. PLoS One
- Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats
- (2010) A. Ulusoy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments
- (2009) T. T. Pham et al. GENES BRAIN AND BEHAVIOR
- Impaired dopamine release and synaptic plasticity in the striatum ofParkin−/− mice
- (2009) Tohru Kitada et al. JOURNAL OF NEUROCHEMISTRY
- Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
- (2009) Tohru Kitada et al. JOURNAL OF NEUROCHEMISTRY
- Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)
- (2009) E. Andres-Mateos et al. JOURNAL OF NEUROSCIENCE
- Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
- (2009) B. Kadkhodaei et al. JOURNAL OF NEUROSCIENCE
- Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant -Synuclein
- (2009) X.-H. Lu et al. JOURNAL OF NEUROSCIENCE
- PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death
- (2009) Sonia Gandhi et al. MOLECULAR CELL
- No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
- (2009) Glenda Halliday et al. MOVEMENT DISORDERS
- Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
- (2009) Yanping Li et al. NATURE NEUROSCIENCE
- Selective noradrenergic vulnerability in alpha-synuclein transgenic mice
- (2009) Evangelos Sotiriou et al. NEUROBIOLOGY OF AGING
- A highly reproducible rotenone model of Parkinson's disease
- (2009) Jason R. Cannon et al. NEUROBIOLOGY OF DISEASE
- Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
- (2009) Xian Lin et al. NEURON
- Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity
- (2009) Xiaomin Su et al. NEUROTOXICITY RESEARCH
- A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human α-synuclein A30P+A53T transgenic mice
- (2009) Kazuhiko Ono et al. PARKINSONISM & RELATED DISORDERS
- Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
- (2009) Suzana Gispert et al. PLoS One
- Stereotaxical Infusion of Rotenone: A Reliable Rodent Model for Parkinson's Disease
- (2009) Nian Xiong et al. PLoS One
- R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
- (2009) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Motor impairment and aberrant production of neurochemicals in human α-synuclein A30P+A53T transgenic mice with α-synuclein pathology
- (2008) Masaki Ikeda et al. BRAIN RESEARCH
- Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin
- (2008) G. Martella et al. EXPERIMENTAL NEUROLOGY
- Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice
- (2008) Noelia Granado et al. JOURNAL OF NEUROCHEMISTRY
- Modeling PD pathogenesis in mice: Advantages of a chronic MPTP protocol
- (2008) Gloria E. Meredith et al. PARKINSONISM & RELATED DISORDERS
- The 6-hydroxydopamine model: News from the past
- (2008) Fabio Blandini et al. PARKINSONISM & RELATED DISORDERS
- Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
- (2008) C. A. Gautier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice
- (2006) Masaki Wakamatsu et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search