UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

Hsp70 at the membrane: driving protein translocation

(2018) Elizabeth A. Craig   BMC BIOLOGY

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress

(2018) Megan C Kopp et al.   eLife

Early Events in the Endoplasmic Reticulum Unfolded Protein Response

(2018) Steffen Preissler et al.   Cold Spring Harbor Perspectives in Biology

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1

(2018) Diego Acosta-Alvear et al.   eLife

Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude

(2017) Anush Bakunts et al.   eLife

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling

(2015) M. Carrara et al.   EMBO JOURNAL

BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions

(2015) Julia Behnke et al.   JOURNAL OF MOLECULAR BIOLOGY

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

(2015) Marta Carrara et al.   eLife

Phosphoregulation of Ire1 RNase splicing activity

(2014) Filippo Prischi et al.   Nature Communications

Structural analysis of the Sil1–Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor

(2011) Ming Yan et al.   BIOCHEMICAL JOURNAL

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

(2011) Maruf M U Ali et al.   EMBO JOURNAL

A Quantitative Spatial Proteomics Analysis of Proteome Turnover in Human Cells

(2011) François-Michel Boisvert et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

(2008) Kseniya Petrova et al.   EMBO JOURNAL

Quantitative analysis of multi-protein interactions using FRET: Application to the SUMO pathway

(2008) Sarah F. Martin et al.   PROTEIN SCIENCE