Nutraceutical Properties of Polyphenols against Liver Diseases

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Galangin, a Flavonoid from Lesser Galangal, Induced Apoptosis via p53-Dependent Pathway in Ovarian Cancer Cells

(2020) Haizhi Huang et al.   MOLECULES

Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice

(2020) Hedya Jemai et al.   Biomed Research International

Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives

(2019) Sabrina Bimonte et al.   Drug Design Development and Therapy

The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats

(2019) Osama M. Ahmed et al.   Oxidative Medicine and Cellular Longevity

Genistein can ameliorate hepatic inflammatory reaction in nonalcoholic steatohepatitis rats

(2019) Yimin Yin et al.   BIOMEDICINE & PHARMACOTHERAPY

Promotion of growth factor signaling as a critical function of β-catenin during HCC progression

(2019) Eunsun Kim et al.   Nature Communications

Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats

(2019) Hijona et al.   Nutrients

Cocoa Flavanols: Natural Agents with Attenuating Effects on Metabolic Syndrome Risk Factors

(2019) Maria Jaramillo Flores   Nutrients

(-)-Epicatechin attenuates hepatic sinusoidal obstruction syndrome by inhibiting liver oxidative and inflammatory injury

(2019) Zhenlin Huang et al.   Redox Biology

Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP

(2019) Minjing Li et al.   Cells

Kaempferol attenuates liver fibrosis by inhibiting activin receptor–like kinase 5

(2019) Taifu Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effects of Piceatannol and Resveratrol on Sirtuins and Hepatic Inflammation in High-Fat Diet-Fed Mice

(2019) Hee Jae Lee et al.   JOURNAL OF MEDICINAL FOOD

Chrysin ameliorates nonalcoholic fatty liver disease in rats

(2019) Sarayu A. Pai et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo‐controlled, double‐blind clinical trial

(2019) Makan Cheraghpour et al.   PHYTOTHERAPY RESEARCH

Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD)

(2019) Xin Xin et al.   BIOMEDICINE & PHARMACOTHERAPY

Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity

(2019) Aladaileh et al.   Biomolecules

Effects of pterostilbene on diabetes, liver steatosis and serum lipids

(2019) Saioa Gómez-Zorita et al.   CURRENT MEDICINAL CHEMISTRY

The Nrf2/HO-1 Axis as Targets for Flavanones: Neuroprotection by Pinocembrin, Naringenin, and Eriodictyol

(2019) Solomon Habtemariam   Oxidative Medicine and Cellular Longevity

Epigallocatechin-3-Gallate Reduces Hepatic Oxidative Stress and Lowers CYP-Mediated Bioactivation and Toxicity of Acetaminophen in Rats

(2019) Hsien-Tsung Yao et al.   Nutrients

Isorhamnetin Alleviates Steatosis and Fibrosis in Mice with Nonalcoholic Steatohepatitis

(2019) Munkhzul Ganbold et al.   Scientific Reports

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats

(2019) Ayman M. Mahmoud et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Chlorogenic acid ameliorates alcohol-induced liver injuries through scavenging reactive oxygen species

(2018) Hyunjin Kim et al.   BIOCHIMIE

Ellagic acid impedes carbontetrachloride-induced liver damage in rats through suppression of NF-kB, Bcl-2 and regulating Nrf-2 and caspase pathway

(2018) Abdullah Aslan et al.   BIOMEDICINE & PHARMACOTHERAPY

The Global Epidemic of the Metabolic Syndrome

(2018) Mohammad G. Saklayen   CURRENT HYPERTENSION REPORTS

The role of apoptosis in acetaminophen hepatotoxicity

(2018) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

(2018) Panchanan Maiti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance

(2018) Yousef A. Al-Dashti et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

(2018) Sha Li et al.   Oxidative Medicine and Cellular Longevity

Dissecting the molecular pathophysiology of drug-induced liver injury

(2018) Hui Ye et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

(2018) Erika Hernández-Aquino et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective

(2018) Mohammad Farzaei et al.   Nutrients

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

(2018) Peng Chen et al.   Scientific Reports

Dose-Dependent Antifibrotic Effect of Chrysin on Regression of Liver Fibrosis: The Role in Extracellular Matrix Remodeling

(2018) Cornel Balta et al.   Dose-Response

Gallic acid, a common dietary phenolic protects against high fat diet induced DNA damage

(2018) Tahereh Setayesh et al.   EUROPEAN JOURNAL OF NUTRITION

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Delphinidin Ameliorates Hepatic Triglyceride Accumulation in Human HepG2 Cells, but Not in Diet-Induced Obese Mice

(2018) Marcela Parra-Vargas et al.   Nutrients

Blueberry Malvidin-3-galactoside Suppresses Hepatocellular Carcinoma by Regulating Apoptosis, Proliferation, and Metastasis Pathways In Vivo and In Vitro

(2018) Yuehua Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolic syndrome, Mediterranean diet, and polyphenols: Evidence and perspectives

(2018) Mauro Finicelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dietary Lignans: Definition, Description and Research Trends in Databases Development

(2018) Alessandra Durazzo et al.   MOLECULES

Lifestyle Changes for Disease Prevention

(2018) Joanna Petrides et al.   PRIMARY CARE

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

(2018) Mao Mu et al.   Drug Design Development and Therapy

Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress

(2017) He Peiyuan et al.   Evidence-based Complementary and Alternative Medicine

The liver is a metabolic and immunologic organ: A reconsideration of metabolic decompensation due to infection in inborn errors of metabolism (IEM)

(2017) Tatyana N. Tarasenko et al.   MOLECULAR GENETICS AND METABOLISM

(-)-Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high-fat diet

(2017) Hui Cheng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease

(2017) Cheng Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cyanidin-3-O-β-glucoside protects against liver fibrosis induced by alcohol via regulating energy homeostasis and AMPK/autophagy signaling pathway

(2017) Ting Wan et al.   Journal of Functional Foods

Dietary luteolin attenuates chronic liver injury induced by mercuric chloride via the Nrf2/NF-κB/P53 signaling pathway in rats

(2017) Haili Zhang et al.   Oncotarget

Etiologic effects and optimal intakes of foods and nutrients for risk of cardiovascular diseases and diabetes: Systematic reviews and meta-analyses from the Nutrition and Chronic Diseases Expert Group (NutriCoDE)

(2017) Renata Micha et al.   PLoS One

Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats

(2016) Aslı Çetin et al.   Archives of Medical Science

Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress

(2016) Ji Hye Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

(2016) Imanol Zubiete-Franco et al.   JOURNAL OF HEPATOLOGY

Does epicatechin contribute to the acute vascular function effects of dark chocolate? A randomized, crossover study

(2016) James I. Dower et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota

(2016) Yen-Chen Tung et al.   MOLECULES

Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial

(2016) Sepideh Rahmani et al.   PHYTOTHERAPY RESEARCH

Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet

(2016) Shu-Fang Xia et al.   Nutrients

Myricetin: A Dietary Molecule with Diverse Biological Activities

(2016) Deepak Semwal et al.   Nutrients

Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice

(2016) Un Jung et al.   Nutrients

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms

(2016) Inhae Kang et al.   Advances in Nutrition

Intraperitoneal administration of apigenin in liver ischemia/reperfusion injury protective effects

(2016) Anastasia Tsiaousidou et al.   Saudi Journal of Gastroenterology

Hepatoprotective Effect of Kaempferol Against Alcoholic Liver Injury in Mice

(2015) Meng Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice

(2015) Zhiguo Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma

(2015) Mazen Noureddin et al.   Clinics in Liver Disease

Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation

(2015) Sunmin Park et al.   Genes and Nutrition

Protective effects of luteolin against acetaminophen-induced acute liver failure in mouse

(2015) Minghui Tai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms of fibrosis in acute liver failure

(2015) Yingli He et al.   LIVER INTERNATIONAL

Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation

(2015) Sunmin Park et al.   Genes and Nutrition

Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice

(2015) Mahaboob Khan Rasool et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats

(2014) Gokhan Bayramoglu et al.   CYTOTECHNOLOGY

Effects of the Olive-Derived Polyphenol Oleuropein on Human Health

(2014) Barbara Barbaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant Properties of Proanthocyanidins Attenuate Carbon Tetrachloride (CCl4)–Induced Steatosis and Liver Injury in Rats via CYP2E1 Regulation

(2014) Ning Dai et al.   JOURNAL OF MEDICINAL FOOD

Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice

(2014) Gaigai Liu et al.   JOURNAL OF NUTRITION

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease

(2014) Forouzan Faghihzadeh et al.   NUTRITION RESEARCH

Dietary habits and behaviors associated with nonalcoholic fatty liver disease

(2014) Kenichiro Yasutake   WORLD JOURNAL OF GASTROENTEROLOGY

Resources and Biological Activities of Natural Polyphenols

(2014) An-Na Li et al.   Nutrients

Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress

(2013) Lijuan Su et al.   FOOD AND CHEMICAL TOXICOLOGY

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation

(2013) João Marcus Oliveira Andrade et al.   NUTRITION

Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway

(2012) Haitao Shi et al.   TOXICOLOGY

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP–PKA-dependent signaling pathway

(2011) Wei Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

(2011) Mary Lynn Bajt et al.   TOXICOLOGICAL SCIENCES

Dietary intake of pterostilbene, a constituent of blueberries, inhibits the  -catenin/p65 downstream signaling pathway and colon carcinogenesis in rats

(2010) S. Paul et al.   CARCINOGENESIS

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism

(2010) M-H Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Extract of Passion Fruit (Passiflora edulis) Seed Containing High Amounts of Piceatannol Inhibits Melanogenesis and Promotes Collagen Synthesis

(2010) Yuko Matsui et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice

(2010) Soyoung Park et al.   JOURNAL OF HEPATOLOGY

Resveratrol and liver disease: from bench to bedside and community

(2010) Anupam Bishayee et al.   LIVER INTERNATIONAL

Protective effects of quercetin on liver injury induced by ethanol

(2010) Xi Chen   Pharmacognosy Magazine

Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice

(2010) Robert Domitrović et al.   TOXICOLOGY

Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice

(2010) George L. Tipoe et al.   TOXICOLOGY

Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats

(2009) M. A. Felmlee et al.   BRITISH JOURNAL OF NUTRITION

The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production

(2009) Oscar Gonzalez et al.   HEPATOLOGY

A Comparative Analysis of Genistein and Daidzein in Affecting Lipid Metabolism in Rat Liver

(2009) Yoko Takahashi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Epidemiology of Idiosyncratic Drug-Induced Liver Injury

(2009) Lauren Bell et al.   SEMINARS IN LIVER DISEASE

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin

(2008) Yaakov Nahmias et al.   HEPATOLOGY

Cyanidin 3-Rutinoside and Cyanidin 3-Xylosylrutinoside as Primary Phenolic Antioxidants in Black Raspberry

(2008) Artemio Z. Tulio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary Flavonoid Sources in Australian Adults

(2008) Shawn M. Somerset et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL