Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 37, Issue -, Pages 16-24Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.07.033
Keywords
Anthocyanins; Energy metabolism; AMPK/autophagy signaling
Categories
Funding
- National Natural Science Foundation of China [81370528, 81573142]
- Natural Science Foundation of Guangdong Province [2015A030313078]
- Key projects of SYSU [15ykjc09d]
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Cyanidin-3-O-beta-glucoside (Cy-3-G) has protective properties in many diseases. Whether Cy-3-G has protective effects on alcohol induced liver injuries remains uncertain. In our study, mice were fed with a high fat high cholesterol diet (HFC) plus ethanol for 12 weeks. Cy-3-G supplementation reversed the liver damage induced by alcohol. In vitro studies, Cy-3-G restored the intracellular energy status of LX-2 cells and inhibited the activation of LX-2 cells induced by ethanol plus palmitate. The protective effect of Cy-3-G is via the increase of AMPK phosphorylation and autophagy. In conclusion, Cy-3-G ameliorated chronic alcoholic liver injuries, possibly by improving energy metabolic status. Specifically, liver fibrosis was protected by Cy-3-G via inhibiting the activation of stellate cells, which was mediated partially by AMPK/autophagy signaling pathway. (C) 2017 Elsevier Ltd. All rights reserved.
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