Dissecting the molecular pathophysiology of drug-induced liver injury

An Animal Model of Abacavir-Induced HLA-Mediated Liver Injury

(2018) Binbin Song et al.   TOXICOLOGICAL SCIENCES

CSH guidelines for the diagnosis and treatment of drug-induced liver injury

(2017) Yue-cheng Yu et al.   Hepatology International

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

(2017) Andrea Iorga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The transformation in biomarker detection and management of drug-induced liver injury

(2017) Rachel J. Church et al.   LIVER INTERNATIONAL

Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery

(2017) Valentina Peta et al.   PLoS One

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

(2017) J. Jiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury

(2016) Francisco Javier Cubero et al.   GASTROENTEROLOGY

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury

(2016) Xi Qiu et al.   MOLECULAR PHARMACEUTICS

Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy

(2015) Satoru Kobayashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phloretin ameliorates arsenic trioxide induced mitochondrial dysfunction in H9c2 cardiomyoblasts mediated via alterations in membrane permeability and ETC complexes

(2015) Vadavanath Prabhakaran Vineetha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis

(2015) Lily Dara et al.   HEPATOLOGY

The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury

(2015) A Tailor et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response

(2015) Katie D. White et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Metabolic activation and drug-induced liver injury:in vitroapproaches for the safety risk assessment of new drugs

(2015) M. José Gómez-Lechón et al.   JOURNAL OF APPLIED TOXICOLOGY

Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice

(2015) Jessica A. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein Kinases

(2015) Ashley R. Maiuri et al.   TOXICOLOGICAL SCIENCES

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

(2015) Jiangting Hu et al.   TOXICOLOGICAL SCIENCES

Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury

(2015) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells

(2015) Yuchao Xie et al.   XENOBIOTICA

ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

(2014) Naga P Chalasani et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulated Cell Death: Signaling and Mechanisms

(2014) Avi Ashkenazi et al.   Annual Review of Cell and Developmental Biology

Autophagy revisited: A conversation with Christian de Duve

(2014) Daniel J. Klionsky   Autophagy

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

(2014) Yvonne Will et al.   Expert Opinion on Drug Metabolism & Toxicology

Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset

(2014) Robert J. Fontana et al.   GASTROENTEROLOGY

Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways

(2014) Gilda M. Kalinec et al.   HEARING RESEARCH

The many functions of the endoplasmic reticulum chaperones and folding enzymes

(2014) Laura Halperin et al.   IUBMB LIFE

Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice

(2014) Zhuofeng Lin et al.   JOURNAL OF HEPATOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Plug Release Mechanism for Membrane Permeation by MLKL

(2014) Lijing Su et al.   STRUCTURE

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways

(2013) Jing Wang et al.   APOPTOSIS

Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis

(2013) James W. Dear et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Drug-induced Acute Liver Failure

(2013) William M. Lee   Clinics in Liver Disease

Drug-Induced Liver Injury: Mechanisms, Types and Biomarkers

(2013) M. Vinken et al.   CURRENT MEDICINAL CHEMISTRY

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

(2013) Dotan Uzi et al.   JOURNAL OF HEPATOLOGY

HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity

(2013) Camilla Stephens et al.   PLoS One

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Role of immune reactions in drug-induced liver injury (DILI)

(2012) Cynthia Ju et al.   DRUG METABOLISM REVIEWS

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury

(2012) Brittany V. Martin-Murphy et al.   HEPATOLOGY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure

(2012) James E. Fisher et al.   JOURNAL OF SURGICAL RESEARCH

Frequency of adverse drug reactions in hospitalized patients: a systematic review and meta-analysis

(2012) Ana Miguel et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

(2012) Ana Alfirevic et al.   Genome Medicine

CD95 death receptor and epidermal growth factor receptor (EGFR) in liver cell apoptosis and regeneration

(2011) Roland Reinehr et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice

(2011) Sanda Win et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mechanisms of drug-induced liver injury: from bedside to bench

(2011) Shannan Tujios et al.   Nature Reviews Gastroenterology & Hepatology

Microsomal oxidative damage promoted by acetaminophen metabolism

(2011) María Eugenia Letelier et al.   TOXICOLOGY IN VITRO

Signaling cell death from the endoplasmic reticulum stress response

(2010) Gordon C Shore et al.   CURRENT OPINION IN CELL BIOLOGY

The potential of cytokines as safety biomarkers for drug-induced liver injury

(2010) Hugh G. Laverty et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Pathological aspects of lipid peroxidation

(2010) Anne Negre-Salvayre et al.   FREE RADICAL RESEARCH

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

(2010) Anup Ramachandran et al.   FREE RADICAL RESEARCH

A role for the pregnane X receptor in flucloxacillin-induced liver injury

(2010) Elise Andrews et al.   HEPATOLOGY

Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation

(2010) Benjamin D. Cosgrove et al.   Molecular BioSystems

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation

(2009) Rick D. Fannin et al.   HEPATOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of Idiosyncratic Drug-Induced Liver Injury

(2009) Lauren Bell et al.   SEMINARS IN LIVER DISEASE

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice

(2009) Brittany V. Martin-Murphy et al.   TOXICOLOGY LETTERS

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells

(2008) Qiang You et al.   HEPATOLOGY

Innate immunity and acetaminophen-induced liver injury: Why so many controversies?

(2008) Hartmut Jaeschke   HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY