Article
Biochemistry & Molecular Biology
Tung-Yu Tiong, Pei-Wei Weng, Chun-Hua Wang, Syahru Agung Setiawan, Vijesh Kumar Yadav, Narpati Wesa Pikatan, Iat-Hang Fong, Chi-Tai Yeh, Chia-Hung Hsu, Kuang-Tai Kuo
Summary: This study investigated the role of SREBP-1 in NSCLC biology, progression, and therapeutic response and found that the targeting of SREBP-1/hsa-miR-497 signaling axis could be a potentially effective anticancer therapeutic strategy for NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Chunming Cheng, Feng Geng, Zoe Li, Yaogang Zhong, Huabao Wang, Xiang Cheng, Yue Zhao, Xiaokui Mo, Craig Horbinski, Wenrui Duan, Arnab Chakravarti, Xiaolin Cheng, Deliang Guo
Summary: In this study, researchers found that ammonia released from glutaminolysis activates SREBP-1 and promotes lipogenesis, thus supporting tumor growth. The study reveals the role of ammonia as a key activator in promoting lipid synthesis through dissociation of SCAP-Insig and activation of SREBP-1. It also demonstrates the critical role of SCAP as a sensor for glutamine, glucose, and sterol levels in precise control of lipid synthesis.
Editorial Material
Cell Biology
Thuy T. P. Nguyen, Do-Young Kim, Seung-Soon Im, Tae-Il Jeon
Summary: Nonalcoholic fatty liver disease affects a quarter of the global population with its pathogenesis not completely understood. A recent study has shown that SREBF1/SREBP-1c contributes to hepatic lipid accumulation through increased lipid synthesis and decreased lipid degradation mediated by autophagic dysregulation.
Article
Plant Sciences
Qi Zheng, Xiaojiaoyang Li, Nana Huang, Fanghong Li, Junde Ge, Daijie Wang, Rong Sun, Runping Liu
Summary: This study demonstrated that Saikosaponins (SSs) from traditional Chinese medicine have therapeutic effects on hyperlipidemia by reducing the levels of cholesterol and triglyceride, improving the imbalance of lipid metabolism, and reducing oxidative stress and inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Min Jin, Yuedong Shen, Tingting Pan, Tingting Zhu, Xuejiao Li, Fangmin Xu, Monica B. Betancor, Lefei Jiao, Douglas R. Tocher, Qicun Zhou
Summary: The study found that betaine, as a lipid-lowering substance, has significant effects on lipid metabolism and inflammation regulation in juvenile black seabream, reducing hepatic steatosis and attenuating inflammatory responses by modulating multiple signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lena Seidemann, Anne Krueger, Victoria Kegel-Huebner, Daniel Seehofer, Georg Damm
Summary: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of end-stage liver disease, with unsatisfactory pharmacological treatment options available. Genistein, a soy isoflavone, shows beneficial effects on lipid metabolism and may be a candidate for NAFLD treatment. In an in vitro model, genistein treatment affects PPAR alpha and SREBP-1c signaling pathways, playing a significant role in hepatic lipid metabolism.
Article
Multidisciplinary Sciences
Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Keizo Takao, Tsuyoshi Miyakawa, Yosuke Matsushita, Toyomasa Katagiri, Akira Futatsugi, Yohei Shinmyo, Hiroshi Kawasaki, Juro Sakai, Kazutaka Shiomi, Masamitsu Nakazato, Kohsuke Takeda, Katsuhiko Mikoshiba, Hidde L. Ploegh, Hidenori Ichijo, Hideki Nishitoh
Summary: Derlin family members play a crucial role in brain development, with the lack of Derlin-1 or Derlin-2 resulting in developmental defects and motor control issues, along with an impact on cholesterol biosynthesis.
Article
Biochemistry & Molecular Biology
Shanglei Lai, Yue Ma, Liuyi Hao, Qinchao Ding, Kaixin Chang, Hui Zhuge, Jiannan Qiu, Tiantian Xu, Xiaobing Dou, Songtao Li
Summary: Alcohol abuse and ALD pose significant health risks, and long-term alcohol intake-induced hepatic steatosis remains poorly understood. This study explored the role of 1-MNA, a metabolite in NAD+ metabolism, in ALD pathogenesis. The results showed that 1-MNA administration enhanced alcohol-induced hepatic steatosis and exacerbated the expression of key enzymes involved in lipid lipogenesis. Furthermore, it increased hepatic ER stress markers. This study demonstrated that 1-MNA is a pathogenic factor in ALD development and targeting its levels may be a potential therapeutic approach.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Environmental Sciences
Chih-Hsiang Shun, Tzu-Hsuen Yuan, Shou-Hung Hung, Yen-Po Yeh, Yi-Hsuan Chen, Chang-Chuan Chan
Summary: This study investigated the association between serum metal levels and the risk of hyperlipidemia in adults living near a petrochemical complex. Results showed that increased serum chromium, arsenic, and mercury levels were significantly associated with total cholesterol levels, with mercury levels also correlated with LDL-C levels. Higher arsenic and mercury levels were associated with increased odds ratios for abnormal total cholesterol levels and the risk of hyperlipidemia.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Fengfeng Li, Man Jiang, Minghui Ma, Xuyang Chen, Yidan Zhang, Yixin Zhang, Yuanyuan Yu, Yunfeng Cui, Jiahui Chen, Hui Zhao, Zhijie Sun, Deli Dong
Summary: Nitazoxanide, an FDA-approved drug, exhibits mild mitochondrial uncoupling and activates AMPK in liver cells. It shows therapeutic effects in improving hyperlipidemia and hepatic steatosis, making it a promising treatment option.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Yu-Lin Chao, Pei-Yu Wu, Jiun-Chi Huang, Yi-Wen Chiu, Jia-Jung Lee, Szu-Chia Chen, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
Summary: This study aimed to investigate the relationships between white blood cell (WBC) and platelet counts with hepatic steatosis and its severity. The results showed that WBC and platelet counts were associated with hepatic steatosis and its severity.
Article
Plant Sciences
Yajuan Bi, Xue Wang, Lifeng Han, Yiqing Tian, Tongwei Bo, Caiyu Li, Bowen Shi, Chunshan Gui, Youcai Zhang
Summary: This study systematically investigated the inhibitory effect of 200 natural products on OCT1 and identified benzoylpaeoniflorin as the most potent and selective OCT1 inhibitor. Benzoylpaeoniflorin prevented lipid accumulation in hepatocytes and down-regulated lipogenic genes. These findings provide valuable insights into natural product-drug interactions involving OCT1 and offer potential for treating fatty liver diseases.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Pharmacology & Pharmacy
Carlos Torrado-Salmeron, Victor Guarnizo-Herrero, Joana Henriques, Raquel Seica, Cristina M. Sena, Santiago Torrado-Santiago
Summary: This study aimed to develop multiparticulate systems with ezetimibe and atorvastatin, showing promising results in diabetic rats by reducing hyperlipidemia and hepatic steatosis.
Article
Agriculture, Multidisciplinary
Haizhao Song, Yanhui Zhang, Qianqian Huang, Rou Deng, Xiaodong Zheng
Summary: This study investigated the in vivo protective effect of Averrhoa carambola L. fruit polyphenols (ACFP) on hyperlipidemia, hepatic steatosis, and hyperglycemia in mice with high-fat diet (HFD)-induced obesity and elucidated the underlying mechanisms. The results showed that ACFP decreased body weight gain, serum triglycerides, total cholesterol, glucose, insulin resistance index, and steatosis grade in the HFD-induced obese mice. Gene expression analysis also indicated that ACFP treatment improved lipid and glucose metabolism. Therefore, ACFP protected against HFD-induced obesity and its associated metabolic complications in mice.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Pharmacology & Pharmacy
Ying Shi, Ruixue Feng, Jieqi Mao, Shuangping Liu, Zhilei Zhou, Zhongwei Ji, Shuguang Chen, Jian Mao
Summary: This study demonstrates that huangjiu peptides derived from Chinese rice wine can alleviate high-fat diet-induced hyperlipidemia and hepatic lipid accumulation, restore gut microbial community structure, and regulate gut ecology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Qingmei Cui, Zhongying Liu, Jianxin Li, Fangchao Liu, Xiaoge Niu, Chong Shen, Dongsheng Hu, Keyong Huang, Shufeng Chen, Yingxin Zhao, Fanghong Lu, Xiaoqing Liu, Jie Cao, Laiyuan Wang, Hongxia Ma, Ling Yu, Xianping Wu, Ying Li, Huan Zhang, Xingbo Mo, Liancheng Zhao, Zhibin Hu, Hongbing Shen, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: This study aims to examine whether adherence to ideal cardiovascular health (CVH) can mitigate the genetic risk of coronary artery disease (CAD) in non-European populations. The results showed that individuals with a favourable CVH profile demonstrated similar relative effects across Polygenic Risk Score (PRS) categories, reducing the CAD relative risk by a similar magnitude. Individuals with high PRS achieved the greatest benefit from favourable CVH, mitigating the risk to the average level of the population. Attaining favourable CVH should be encouraged for all individuals, especially those with high genetic susceptibility.
Article
Peripheral Vascular Disease
Xuanming Hong, Ke Miao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
Summary: This study identified CpG sites associated with systolic and diastolic blood pressure and examined the temporal relationship between DNA methylation and blood pressure. The findings suggest the significance of DNA methylation in the development of hypertension.
Article
Peripheral Vascular Disease
Han Ma, Fangchao Liu, Jianxin Li, Jichun Chen, Jie Cao, Shufeng Chen, Xiaoqing Liu, Xueli Yang, Keyong Huang, Chong Shen, Ling Yu, Yingxin Zhao, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: Based on a study conducted in China, the association between socioeconomic status (SES) and hypertension remains uncertain. Individuals with lower SES are at a higher risk of developing hypertension compared to those with higher SES. Moreover, women are more susceptible to the adverse effects of lower SES on hypertension.
Article
Engineering, Electrical & Electronic
Chao Wang, Guanghui Xu, Minquan Li, Zhixiang Huang, Xingang Ren, Jingping Wang, Xianliang Wu
Summary: In this paper, an ultrawideband millimeter-wave bidirectional circularly polarized monopole antenna array is proposed. The antenna array utilizes a broadband CP monopole antenna element and a SRF technique to improve the AR bandwidth. The measured results show that the proposed antenna array has a wide impedance bandwidth and high gain for mm-Wave applications.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Engineering, Electrical & Electronic
Qian Chen, Jian Chen, Aidi Ren, Wei Wang, Zhixiang Huang, Lixia Yang, Xianliang Wu, Xianling Liang
Summary: The study proposes a metal solar-cell phased array antenna composed of 36 units with a rectangular grid. The antenna is made up of leaf-shaped metal radiators, feeding and ground probes, a solar cell, and a metal ground. The solar cell is located on the metal ground, and the radiators are hollowed out to reduce shadow area. The antenna has a wide working bandwidth, a high phase scanning angle, high aperture efficiency, and high output power compared to a pure solar cell. This scalable antenna can be used for CubeSats.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Review
Biochemistry & Molecular Biology
Ting Zhang, Qi Liu, Zhuo Li, Siqi Tang, Qimin An, Dongdong Fan, Yiwei Xiang, Xianli Wu, Zhe Jin, Jianhong Ding, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie
Summary: Ion channels are integral membrane proteins that allow the permeation of charge ions across hydrophobic phospholipid membranes. They play a crucial role in establishing membrane potential by regulating ion concentration, and are involved in various immune-related diseases in major human organs.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Xuanming Hong, Zhiyu Wu, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Liming Cong, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
Summary: This study found that both genetic and environmental factors play essential roles in obesity and cardiometabolic disease traits. However, as age increases, the influence of genetic factors decreases and the importance of environmental factors increases.
Article
Energy & Fuels
Xianguo Wu, Xinyi Li, Yawei Qin, Wen Xu, Yang Liu
Summary: In this study, an intelligent optimization method integrating the BIM-DB and PSO-RF-NSGA-III methods was established for the energy saving design and optimization of near-zero-energy-consumption buildings (NZEBs). The method was applied to explore multiobjective optimization problems in four typical climate regions in China. The results showed that the PSO-RF algorithm efficiently predicted building energy consumption, carbon emissions, and thermal comfort. After optimization, the energy consumption levels in the four regions were reduced by 39.72%, 32.22%, 26.94%, and 35.37%, respectively, and other goals were also optimized. The optimized building design parameters met the standards for NZEBs, with varying influencing factors and measures across different regions.
Article
Mathematics, Applied
Xian Wu, Kaihua Xi, Aijie Cheng, Hai Xiang Lin, Jan H. H. van Schuppen
Summary: We aim to enhance the ability of coupled phase oscillators to maintain synchronization under stochastic disturbances by proposing an optimization method. We model the disturbances as Gaussian noise and measure synchronization stability using mean first hitting time. The optimization method increases the mean first hitting time and identifies vulnerable edges in the system, increasing synchronization stability.
Correction
Physics, Multidisciplinary
Yuhao Gu, Kun Jiang, Xianxin Wu, Jiangping Hu
CHINESE PHYSICS LETTERS
(2023)
Article
Automation & Control Systems
Bin Chen, Lei Wang, Zongbao Feng, Yang Liu, Xianguo Wu, Yawei Qin, Lingyu Xia
Summary: A hybrid intelligent framework based on random forest (RF) and non-dominated sorting genetic algorithm version II (NSGA-II) is developed to predict the durability and optimize the mix ratio of high-durability concrete. The proposed RF-NSGA-II framework effectively predicts concrete durability and achieves a high standard of frost resistance and chloride ion permeability coefficient at a low cost. The developed RF model has excellent regression learning ability, with high goodness of fit and low error values. This framework can provide guidance for optimizing concrete mix design and similar projects.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Engineering, Electrical & Electronic
Shaobo He, Longxiang Fu, Yao Lu, Xianming Wu, Huihai Wang, Kehui Sun
Summary: This paper introduces the analog circuit of a simplified Tent map and its applications in sensor position optimization. The experimental results of the circuit are consistent with the numerical simulation results, indicating the system's complex dynamic behaviors. By incorporating the generated time series from the simplified Tent map into the PSO algorithm, its random detection ability is enhanced, resulting in a more satisfying optimization result for sensor position in wireless sensor networks. This suggests that the proposed analog circuit and chaotic POS algorithm have potential engineering application values compared to previous studies on chaotic maps.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Psychiatry
Zelin Yuan, Huamin Liu, Xiaochun Zhang, Yong He, Shanyuan Gu, Dan Mo, Shaoli Wang, Zhiwei Huang, Keyi Wu, Rui Zhou, Qi Zhong, Yining Huang, Bifei Cao, Haowen Chen, Xianbo Wu
Summary: Previous studies have found that high uric acid (UA) is associated with enhanced patient function. This study aims to clarify the relationship between UA and cognitive impairment in patients with schizophrenia (SCZ) and explore whether UA could be used as a potential biological marker of cognition in SCZ during maintenance period. The results showed that UA is positively associated with cognitive function, and high UA is associated with enhanced cognition in patients with low anticholinergic cognitive burden (ACB).
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Kun Liao, Yangguang Zhong, Zhuochen Du, Guodong Liu, Chentong Li, Xianxin Wu, Chunhua Deng, Cuicui Lu, Xingyuan Wang, Che Ting Chan, Qinghai Song, Shufeng Wang, Xinfeng Liu, Xiaoyong Hu, Qihuang Gong
Summary: In this paper, a scalable strategy is proposed to realize a robust on-chip integrated visible microlaser with improved lasing performance. The strategy is experimentally verified by demonstrating a second-order exceptional surface-tailored microlaser and further discussed for potential applications. This work lays a foundation for the development of high-speed visible-light communication and processing systems, provides a platform for the study of non-Hermitian photonics, and proposes a feasible method of joint research for non-Hermitian photonics with nonlinear optics and topological photonics.
Review
Environmental Sciences
Shuhan Meng, Hua Li, Xianhua Wu
Summary: This paper systematically analyzes cruise research literature from 1996 to 2019 collected in the science network database. The results show that: the number of published literatures on cruise research is increasing overall; North America, Europe, and Asia are the main regions of cruise research. The theme development of cruise research has three stages, and the current hot topics of cruise research include cruise tourism, luxury cruises, cruise passengers, destination ports, environmental and biological conservation, and cruise diseases.
FRONTIERS IN MARINE SCIENCE
(2023)
