Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 117, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2019.109047
Keywords
Genistein; Soy; Nonalcoholic steatohepatitis (NASH); Non-alcoholic fatty liver disease (NAFLD); Review
Funding
- National Natural Science Foundation of China [81573668, 881830119]
- National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program', China [2018ZX09201001-001-002]
- Shanghai science and Technology Innovation Fund [18401933100]
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NAFLD is a vital health problem worldwide; however, no effective treatment is currently available for NAFLD. Intensive studies have indicated the efficacy of genistein (GE), a bioactive isoflavone extracted from soy, in treating NAFLD. In addition to its oestrogen-like effects, GE is known to have multiple molecular effects, for instance, lipid and glucose metabolism-promoting effects and activities against lipid peroxidation, inflammation, fibrosis, and NAFLD-related tumours. Here, this review summarizes the potential role of GE in the treatment and prevention of NAFLD and some of the currently known targets and signalling pathways of GE in NAFLD.
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