The Nrf2/HO-1 Axis as Targets for Flavanones: Neuroprotection by Pinocembrin, Naringenin, and Eriodictyol

Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes in vitro and in vivo

(2019) Rashmi Rajappa et al.   Frontiers in Pharmacology

Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression

(2019) Zhiyou Yang et al.   PHYTOTHERAPY RESEARCH

Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo

(2019) Qiu Liu et al.   CELL STRESS & CHAPERONES

Natural Products in Alzheimer’s Disease Therapy: Would Old Therapeutic Approaches Fix the Broken Promise of Modern Medicines?

(2019) Habtemariam   MOLECULES

Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression

(2019) Solomon Habtemariam   Oxidative Medicine and Cellular Longevity

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

(2019) Mei‐Zhou Huang et al.   Acta Physiologica

Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases

(2019) Fabiane Valentini Francisqueti-Ferron et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eriodictyol alleviates lipopolysaccharide‐triggered oxidative stress and synaptic dysfunctions in BV‐2 microglial cells and mouse brain

(2019) Pandi He et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bacterial Translocation Is Linked to Increased Intestinal IFN-γ, IL-4, IL-17, and mucin-2 in Cholestatic Rats

(2018) Natali Vega-Magaña et al.   Annals of Hepatology

Neuroprotective effects of pinocembrin on ischemia/reperfusion-induced brain injury by inhibiting autophagy

(2018) Jinhao Tao et al.   BIOMEDICINE & PHARMACOTHERAPY

Across the blood-brain barrier: Neurotherapeutic screening and characterization of naringenin as a novel CRMP-2 inhibitor in the treatment of Alzheimer's disease using bioinformatics and computational tools

(2018) Maryam Lawal et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Involvement of Heme Oxygenase-1 in Neuropsychiatric and Neurodegenerative Diseases

(2018) Vivian B. Neis et al.   CURRENT PHARMACEUTICAL DESIGN

Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge in the rat

(2018) Mohammad-Reza Khajevand-Khazaei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation

(2018) Shadab Md et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Protective effect of ethyl acetate fraction of Drynaria quercifolia against CCl 4 induced rat liver fibrosis via Nrf2/ARE and NFκB signalling pathway

(2018) G.I. Anuja et al.   JOURNAL OF ETHNOPHARMACOLOGY

In Silico Docking and In Vitro Approaches towards BACE1 and Cholinesterases Inhibitory Effect of Citrus Flavanones

(2018) Seungeun Lee et al.   MOLECULES

Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects

(2018) Solomon Habtemariam   MOLECULES

The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs

(2018) Solomon Habtemariam   Neural Regeneration Research

Naringenin Exerts Anti-inflammatory Effects in Paraquat-Treated SH-SY5Y Cells Through a Mechanism Associated with the Nrf2/HO-1 Axis

(2018) Marcos Roberto de Oliveira et al.   NEUROCHEMICAL RESEARCH

Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson’s Disease Model in Mice

(2018) Sugumar Mani et al.   NEUROTOXICITY RESEARCH

Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives

(2018) Ilkay Erdogan Orhan et al.   PHYTOMEDICINE

Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model

(2018) YinZhong Ma et al.   Biomed Research International

Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-κB in Male C57BL/6J Mice and BV2 Microglial Cells

(2018) Pandi He et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Corrigendum to “Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways”

(2018) Yong Li et al.   MEDIATORS OF INFLAMMATION

Regenerative Effects of Heme Oxygenase Metabolites on Neuroinflammatory Diseases

(2018) Huiju Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells

(2018) Peilin Lv et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model

(2018) Tahir Muhammad et al.   Journal of Neuroimmune Pharmacology

Highly Cancer Selective Antiproliferative Activity of Natural Prenylated Flavonoids

(2018) Agnieszka Bartmańska et al.   MOLECULES

Naringenin targets on astroglial Nrf2 to support dopaminergic neurons

(2018) Guo-Qing Wang et al.   PHARMACOLOGICAL RESEARCH

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide ( t -BHP)-induced mitochondrial dysfunction and cell death

(2017) Hongming Lv et al.   FREE RADICAL BIOLOGY AND MEDICINE

Naringenin reduces oxidative stress and improves mitochondrial dysfunction via activation of the Nrf2/ARE signaling pathway in neurons

(2017) Kaihua Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Pinocembrin Suppresses H2O2-Induced Mitochondrial Dysfunction by a Mechanism Dependent on the Nrf2/HO-1 Axis in SH-SY5Y Cells

(2017) Marcos Roberto de Oliveira et al.   MOLECULAR NEUROBIOLOGY

Naringenin Attenuates H2O2-Induced Mitochondrial Dysfunction by an Nrf2-Dependent Mechanism in SH-SY5Y Cells

(2017) Marcos Roberto de Oliveira et al.   NEUROCHEMICAL RESEARCH

Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ

(2017) Kathrin Pallauf et al.   Oxidative Medicine and Cellular Longevity

Anti‐inflammatory and anti‐arthritic properties of naringenin via attenuation of NF‐κB and activation of the heme oxygenase ﴾HO﴿‐1/related factor 2 pathway

(2017) Rong Fan et al.   Pharmacological Reports

Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii

(2017) Zhenxing Zou et al.   PHYTOCHEMISTRY

Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway

(2017) Yan Zhang et al.   REJUVENATION RESEARCH

Differentiation impairs Bach1 dependent HO-1 activation and increases sensitivity to oxidative stress in SH-SY5Y neuroblastoma cells

(2017) Sabrina Piras et al.   Scientific Reports

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

(2016) Emerson de Oliveira Ferreira et al.   BEHAVIOURAL BRAIN RESEARCH

Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes

(2016) Yeon-Hui Jeong et al.   Biomolecules & Therapeutics

Pinocembrin attenuates gentamicin-induced nephrotoxicity in rats

(2016) Sasivimon Promsan et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation

(2016) Cheng-zhen Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effects of naringenin in cardiorenal syndrome

(2016) Yan Liu et al.   JOURNAL OF SURGICAL RESEARCH

Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells

(2016) Yumin Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke

(2016) Shuai Jiang et al.   MOLECULAR NEUROBIOLOGY

Pinocembrin Provides Mitochondrial Protection by the Activation of the Erk1/2-Nrf2 Signaling Pathway in SH-SY5Y Neuroblastoma Cells Exposed to Paraquat

(2016) Marcos Roberto de Oliveira et al.   MOLECULAR NEUROBIOLOGY

Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2–Nrf2 Signaling Pathway

(2016) Marcos Roberto de Oliveira et al.   NEUROCHEMICAL RESEARCH

Pinocembrin attenuates MPP + -induced neurotoxicity by the induction of heme oxygenase-1 through ERK1/2 pathway

(2016) Hongquan Wang et al.   NEUROSCIENCE LETTERS

Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome

(2016) Nader G. Abraham et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice

(2016) Renata M. Martinez et al.   PLoS One

Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−KATPChannel Signaling Pathway

(2016) Marília F. Manchope et al.   PLoS One

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

(2015) Saeed Ghofrani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

(2015) Lu-ting Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Heme oxygenase-1-derived bilirubin protects endothelial cells against high glucose-induced damage

(2015) Meihua He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Eriodictyol Protects Endothelial Cells against Oxidative Stress-Induced Cell Death through Modulating ERK/Nrf2/ARE-Dependent Heme Oxygenase-1 Expression

(2015) Seung Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression

(2015) Ling-Hsuan Wu et al.   MOLECULAR NEUROBIOLOGY

Eriodictyol Attenuates β-Amyloid 25–35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2

(2015) Xu Jing et al.   NEUROCHEMICAL RESEARCH

Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion

(2015) Muhammed A. Saad et al.   Pharmacological Reports

Protective Effects of Naringenin on Iron-Overload-Induced Cerebral Cortex Neurotoxicity Correlated with Oxidative Stress

(2014) Yassine Chtourou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

HO-1 attenuates hippocampal neurons injury via the activation of BDNF–TrkB–PI3K/Akt signaling pathway in stroke

(2014) Dashi Qi et al.   BRAIN RESEARCH

Pinocembrin Attenuates 6-OHDA-induced Neuronal Cell Death Through Nrf2/ARE Pathway in SH-SY5Y Cells

(2014) Xiaohua Jin et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Naringenin attenuates CCl4-induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats

(2014) Mohammad Ali Esmaeili et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Naringenin Exerts Cytoprotective Effect Against Paraquat-Induced Toxicity in Human Bronchial Epithelial BEAS-2B Cells Through NRF2 Activation

(2014) Biswajit Podder et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Pinocembrin Protects SH-SY5Y Cells Against MPP+-Induced Neurotoxicity Through the Mitochondrial Apoptotic Pathway

(2014) Yumin Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Naringenin confers protection against oxidative stress through upregulation of Nrf2 target genes in cardiomyoblast cells

(2014) Tharmarajan Ramprasath et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Pinocembrin Protects the Brain against Ischemia-Reperfusion Injury and Reverses the Autophagy Dysfunction in the Penumbra Area

(2014) Gang Zhao et al.   MOLECULES

Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway

(2014) Young-Sam Keum et al.   MOLECULES

Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits

(2014) Rui Liu et al.   NEUROBIOLOGY OF AGING

Heme oxygenase-1 protects against Alzheimer’s amyloid-β1-42-induced toxicity via carbon monoxide production

(2014) N Hettiarachchi et al.   Cell Death & Disease

Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid-β1−40Injury by Suppressing the MAPK/NF-κB Inflammatory Pathways

(2014) Rui Liu et al.   Biomed Research International

Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway

(2013) Mohammed Qaisiya et al.   CELLULAR SIGNALLING

Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats

(2013) Wenqing Yang et al.   NEUROLOGICAL SCIENCES

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Sesamol and naringenin reverse the effect of rotenone-induced PD rat model

(2013) M. Sonia Angeline et al.   NEUROSCIENCE

Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis

(2013) Cai-xia Wu et al.   NEUROSCIENCE LETTERS

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL

Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury

(2013) Xu Jing et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Photoprotection of human dermal fibroblasts against ultraviolet light by antioxidant combinations present in tomato

(2013) Elisabet Fernández-García   Food & Function

Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits

(2012) Jung Keun Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis

(2012) Rui Liu et al.   BMC Medicine

Targeting Heme Oxygenase-1 for Neuroprotection and Neuroinflammation in Neurodegenerative Diseases

(2012) Agnieszka Jazwa et al.   CURRENT DRUG TARGETS

Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity

(2012) Qingwen Hu et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1

(2012) Siyu Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

In Vitro Phytotoxicity and Antioxidant Activity of Selected Flavonoids

(2012) Laura De Martino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway

(2012) Haiyan Lou et al.   NEUROCHEMISTRY INTERNATIONAL

Naringenin ameliorates Alzheimer’s disease (AD)-type neurodegeneration with cognitive impairment (AD-TNDCI) caused by the intracerebroventricular-streptozotocin in rat model

(2012) M. Badruzzaman Khan et al.   NEUROCHEMISTRY INTERNATIONAL

The anti-obesity potential of sigmoidin A

(2012) Solomon Habtemariam   PHARMACEUTICAL BIOLOGY

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

Role of haeme oxygenase-1 in resolution of oxidative stress-related pathologies: focus on cardiovascular, lung, neurological and kidney disorders

(2011) D. D. Haines et al.   Acta Physiologica

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Pinocembrin attenuates blood–brain barrier injury induced by global cerebral ischemia–reperfusion in rats

(2011) Fanrui Meng et al.   BRAIN RESEARCH

The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats

(2011) Li-li Shi et al.   LIFE SCIENCES

Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-κB activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in human airway epithelial cells

(2011) J. Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Nrf2-ARE Pathway

(2010) Jeffrey A. Johnson et al.   Annals of the New York Academy of Sciences

Pinocembrin protects the neurovascular unit by reducing inflammation and extracellular proteolysis in MCAO rats

(2010) Mei Gao et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Overexpression of Heme Oxygenase-1 Is Neuroprotective in a Model of Permanent Middle Cerebral Artery Occlusion in Transgenic Mice

(2010) Nariman Panahian et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective role of heme-oxygenase 1 against iodoacetate-induced toxicity in rat cerebellar granule neurons: Role of bilirubin

(2009) Susana González-Reyes et al.   FREE RADICAL RESEARCH

The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression

(2009) Shih-Ya Hung et al.   NEUROPHARMACOLOGY

Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia–reperfusion both in vivo and in vitro

(2008) Rui Liu et al.   BRAIN RESEARCH

Pinocembrin prevents glutamate-induced apoptosis in SH-SY5Y neuronal cells via decrease of bax/bcl-2 ratio

(2008) Mei Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes

(2008) Xiuzhen Han et al.   FOOD AND CHEMICAL TOXICOLOGY

Overexpression of Heme Oxygenase-1 Protects Dopaminergic Neurons against 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity

(2008) S.-Y. Hung et al.   MOLECULAR PHARMACOLOGY