Article
Cell Biology
Dongqin Wei, Xin Tian, Longbo Zhu, Han Wang, Chao Sun
Summary: This study revealed the important role of ubiquitin-specific proteinase 14 (USP14) in the progression of nonalcoholic fatty liver disease (NAFLD). The overexpression of USP14 exacerbated the progression of NAFLD, while its knockdown had a mitigating effect. Furthermore, USP14 was found to promote lipid peroxidation and inflammation by regulating the protein level of cytochrome p4502E1 (CYP2E1). The study also demonstrated that USP14 facilitated the accumulation of CYP2E1 protein by inhibiting the degradation of heat shock protein 90 alpha family class A member 1 (HSP90AA1).
CELL DEATH & DISEASE
(2023)
Article
Immunology
Samia Salem Sokar, Mahmoud Abdelrahman Alkabbani, El-Sayed Akool, Sally El- Sayed Abu-Risha
Summary: The study demonstrated that carvedilol, crocin, and their combination have significant protective effects against leflunomide-induced liver injury. The combination treatment was found to be more effective than either drug alone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xin Yan, Yu Wang, Xue-Yang Ren, Xiao-Yun Liu, Jia-Mu Ma, Ruo-Lan Song, Xiu-Huan Wang, Ying Dong, A-Xiang Yu, Qi-Qi Fan, Jing Wei, Gai-Mei She
Summary: The study showed that Thymus quinquecostatus Celak extract has hepatoprotective effects against ALD by improving gut barrier function, modulating gut microbiota, suppressing inflammatory response, and reducing ROS production in the liver.
Article
Biochemistry & Molecular Biology
Shasha Liu, Ruohan Cheng, Hui He, Kunming Ding, Rongmi Zhang, Yuanyuan Chai, Qinwei Yu, Xin Huang, Luyong Zhang, Zhenzhou Jiang
Summary: This study investigated the effect and mechanism of 8-methoxypsoralen (8-MOP) on acetaminophen (APAP)-induced hepatotoxicity in mice. It was found that treatment with different doses of 8-MOP reduced liver damage caused by APAP, as evidenced by decreased serum transaminase levels and histopathological liver necrosis area. 8-MOP achieved this by inhibiting the enzymatic activities of Cyp2e1 and reducing the production of the toxic metabolite APAP-CYS. The results suggest that 8-MOP could be a potential therapeutic agent for APAP-induced liver toxicity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Plant Sciences
Nayeli Amalinalli Pulido-Hornedo, Javier Ventura-Juarez, Fidel Guevara-Lara, Herson Antonio Gonzalez-Ponce, Esperanza Sanchez-Aleman, Manon Buist-Homan, Han Moshage, Ma Consolacion Martinez-Saldana
Summary: This study evaluated the protective effect of Opuntia robusta fruit on liver fibrosis and found that it has antioxidant capacity. The results demonstrated that Opuntia robusta fruit can reduce fibrotic liver damage.
Article
Integrative & Complementary Medicine
Xiaojing Fan, Xiye Wang, Jie Lian, Zhili Pei, Mingyang Jiang, Meirong Bai
Summary: This study aimed to identify the changes in the metabolomics profile of liver tissue damaged by alcohol consumption and explore the potential protective effects of flos carthami. The findings demonstrated that flos carthami attenuated alcohol-induced injury and resulted in changes in the metabolic profiles.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Food Science & Technology
Yuchen Fu, Ziyuan Zeng, Siwen Feng, Yeyang Chen, Qi Ding, Yuanyuan Shi
Summary: Jiubanban (JBB), a 10-edible-herb formula, has shown protective effects against chronic alcoholic liver injury by accelerating ethanol metabolism and modulating multiple pathways related to inflammation, oxidative stress, and apoptosis. It may be a risk-free therapeutic strategy for treating ALD.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Yoon Mee Yang, Ye Eun Cho, Seonghwan Hwang
Summary: Alcoholic liver disease (ALD), caused by excessive alcohol consumption, results in liver damage. Studies have shown that there is a relationship between hepatic oxidative stress and inflammatory responses, which may be useful for developing therapeutic approaches for ALD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marwa S. Serrya, Manar A. Nader, Marwa E. Abdelmageed
Summary: This study demonstrated that nilotinib has a promising hepato-protective role against CsA-induced hepatotoxicity, potentially through its antiapoptotic, antioxidant, and anti-inflammatory effects.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Limin Gao, Xingyu Chen, Zeyu Fu, Jie Yin, Yafen Wang, Weiguang Sun, Hong Ren, Yonghui Zhang
Summary: The study demonstrated that kinsenoside alleviates alcoholic liver injury by reducing oxidative stress and ER stress, while activating AMPK-dependent autophagy. This suggests that kinsenoside may be a potential therapeutic agent for ALD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Ali S. Alshehri, Attalla F. El-kott, Mohamed S. A. El-Gerbed, Ayman E. El-Kenawy, Ghadeer M. Albadrani, Heba S. Khalifa
Summary: The study evaluated the protective effect of kaempferol against cadmium chloride-induced liver damage through antioxidant and anti-inflammatory mechanisms, involving the upregulation of Nr12/HO-1 axis and suppression of NF-kappa B p65 and keap1.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Nami Lee, Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim
Summary: In this study, treatment with dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter 2 inhibitors, or a combination of both was found to ameliorate hepatic steatosis, inflammation, oxidative stress, and fibrosis in CDAHFD-induced NAFLD mouse models. This treatment also inhibited the activity of inflammatory cytokines and chemokines, leading to a reduction in liver triglyceride accumulation and prevention of liver fibrosis progression. The findings suggest that these drugs have the potential to alleviate the progression of NAFLD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
Summary: Ginsenoside Rk3 shows promising therapeutic potential in protecting against APAP-induced acute liver injury by reducing hepatotoxicity, inhibiting liver inflammation and oxidative stress, and promoting continuous activation of autophagy.
Article
Pharmacology & Pharmacy
Suzy Salama, Chin Siang Kue, Haryanti Mohamad, Fatima Omer, Mohamed Yousif Ibrahim, Mahmood Abdulla, Hapipah Ali, Abdalbasit Mariod, Soher Nagi Jayash
Summary: This study evaluated the antioxidant capacity and hepatoprotective potential of the compound quinazoline Q-Br in rats with sub-chronic liver toxicity. The results showed that Q-Br had mild antioxidant capacity, improved liver status, and inhibited oxidative stress. There was also a reduction in the degree of fibrosis. These findings suggest that Q-Br has significant hepatoprotective potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chen Chen, Xiang Liu, Shanshan Qi, Alberto C. P. Dias, Jingkun Yan, Xiaoying Zhang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Multidisciplinary
Yong Hou, Wenyan Xie, Leixiao Yu, Luis Cuellar Camacho, Chuanxiong Nie, Man Zhang, Rainer Haag, Qiang Wei
Article
Biochemical Research Methods
Qi Zhang, Dongyang He, Long Xu, Shikun Ge, Jinquan Wang, Xiaoying Zhang
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2020)
Article
Food Science & Technology
Long Xu, Xiao-yi Suo, Qi Zhang, Xin-ping Li, Chen Chen, Xiao-ying Zhang
Article
Biochemical Research Methods
Long Xu, Jiping Zhou, Sergei Eremin, Alberto C. P. Dias, Xiaoying Zhang
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Long Xu, Xiang Liu, Chen Chen, Alberto C. P. Dias, Xiaoying Zhang
Summary: A rapid immunoassay was established for the determination of DHEA in dietary supplements and pharmaceutical products, demonstrating high sensitivity and reliability.
ANALYTICAL LETTERS
(2021)
Article
Food Science & Technology
Fanfan Yang, Long Xu, Xiang Liu, Chen Chen, Alberto C. P. Dias, Xiaoying Zhang
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Yong Hou, Wenyan Xie, Xin Fan, Peng Tang, Leixiao Yu, Rainer Haag
Summary: The development of raspberry-like hierarchical surfaces with well-defined nanofeatures and tunable nano/microfeatures via catecholic polymer coating technique enhances the mechanosensing of human mesenchymal stem cells (hMSCs) to interfacial physical cues. Cellular responses to these hierarchical interfaces were systematically studied, showing that nanofeatures significantly influence cell mechanotransduction.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Shikun Ge, Rao Wu, Tingting Zhou, Xiang Liu, Jin Zhu, Xiaoying Zhang
Summary: This study suggests that IgY and IgY-scFv are suitable candidates for the development of immunoassay and passive immunotherapy for COVID-19 in both humans and animals.
Article
Chemistry, Multidisciplinary
Yong Hou, Jixiang Jing, Yumeng Luo, Feng Xu, Wenyan Xie, Linjie Ma, Xingyu Xia, Qiang Wei, Yuan Lin, Kwai Hei Li, Zhiqin Chu
Summary: A new method called GaN chipscope is proposed to quantitatively monitor the progression of various intracellular processes in a label-free manner. This method uses a cost-effective, ultrasensitive, and ultracompact GaN photonic chip for photoelectric readout and cellular imaging. The miniaturized chipscope is designed compactly for real-time observation of cell activities. This method shows great potential in both fundamental cell biology studies and clinical applications.
Article
Food Science & Technology
Fanfan Yang, Alberto C. P. Dias, Xiaoying Zhang
Summary: This study developed a sandwich enzyme-linked immunosorbent assay (ELISA) for highly selective and ultra-sensitive quantitative analysis of selenium (Se) in food samples. The approach showed a remarkable limit of detection (LOD) at the femtomolar level and a substantial enhancement in sensitivity. The method was validated by comparing the results with atomic absorption spectrometry (AAS) analysis.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Yuzhang Hu, Mei Dang, Murtala Bindawa Isah, Saeed Yakhkeshi, Chen Chen, Xiaoying Zhang
Summary: This study examined the differences between silky fowl meat (SFM) and Leghorn chicken meat (LCM) using a comprehensive analysis of proteomics, transcriptomics, and metabolomics. Several proteins, genes, and metabolites were found to be differentially expressed or abundant between SFM and LCM, suggesting the involvement of SFM in amino acid biosynthesis and melanogenesis. SFM also contained higher levels of flavor-enhancing factors and pharmacologically significant metabolites.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hao Hao, Youmei Xu, Rui Chen, Shanshan Qi, Xiang Liu, Beibei Lin, Xiaohua Chen, Xiaoying Zhang, Lijuan Yue, Chen Chen
Summary: In this study, we found that chlorogenic acid (CGA) has a significant protective effect against cyclophosphamide (CP) induced liver injury in mice. CGA reduced the levels of liver enzyme in the serum and expressions of malondialdehyde (MDA) in hepatic tissue, while increasing the concentrations of antioxidant enzymes. CGA also increased the protein expression of Nrf2 and up-regulated the mRNA levels of HO-1, NQO1, TNF-α and IL-6 in the liver tissue.
BIOTECHNIC & HISTOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Longjiang Wu, Murtala Isah Bindawa, Siran Zhang, Mei Dang, Xiaoying Zhang
Summary: In this study, ic-ELISA and ic-CLEIA methods were developed for sensitive and selective detection of melatonin in health products. These methods showed good consistency with HPLC, indicating their sensitivity, speed, and reliability for melatonin analysis.
ANALYTICAL METHODS
(2023)
Article
Veterinary Sciences
Shikun Ge, Xingxing Zhang, Fagang Zhong, Xiang Liu, Xiaoying Zhang
Summary: A novel antibody mimetic, chicken IgY mimetic peptide, was developed in this study, showing excellent protective properties against canine parvovirus without cross-reactivity with other viruses. This study demonstrates the feasibility and ease of generating such novel antibody-like functional molecules for biomedical purposes.
VETERINARY RESEARCH
(2021)
