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Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

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Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model

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Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

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Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

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Functional testing of thousands of osteoarthritis-associated variants for regulatory activity

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Targeting downstream subcellular YAP activity as a function of matrix stiffness with Verteporfin-encapsulated chitosan microsphere attenuates osteoarthritis

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Does a high-fat diet affect the development and progression of osteoarthritis in mice? A systematic review

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Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs

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Ghrelin protects against osteoarthritis through interplay with Akt and NF-κB signaling pathways

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Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis

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Senescent cells and osteoarthritis: a painful connection

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Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage

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A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

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Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

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MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway

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MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

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Downregulating PI3K/Akt/NF-κB signaling with allicin for ameliorating the progression of osteoarthritis: in vitro and vivo studies

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The Hippo Pathway: Biology and Pathophysiology

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Inhibition of YAP with siRNA prevents cartilage degradation and ameliorates osteoarthritis development

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Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice

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Wnt-β-catenin signaling pathway inhibition by sclerostin may protect against degradation in healthy but not osteoarthritic cartilage

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High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

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IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity

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Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats

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Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

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Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice

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Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis-like Phenotype in Mice

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Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

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Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

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Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice

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Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep

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Epidemiological Evidence for Work Load as a Risk Factor for Osteoarthritis of the Hip: A Systematic Review

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Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

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An In Vivo Lapine Model for Impact-Induced Injury and Osteoarthritic Degeneration of Articular Cartilage

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Development of a Spring-Loaded Impact Device to Deliver Injurious Mechanical Impacts to the Articular Cartilage Surface

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Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: Establishment and characterization of a long-term cartilage-synovium coculture

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Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: Effects of short-term exercise

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Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

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Association of Knee Osteoarthritis with the Accumulation of Metabolic Risk Factors Such as Overweight, Hypertension, Dyslipidemia, and Impaired Glucose Tolerance in Japanese Men and Women: The ROAD Study

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