Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

Coordinated d -cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway

(2018) Dustin M. Fink et al.   CELLULAR SIGNALLING

Intra-articular drug delivery systems for joint diseases

(2018) Muhammad Farooq Rai et al.   CURRENT OPINION IN PHARMACOLOGY

Gene Delivery to Joints by Intra-Articular Injection

(2018) Christopher H. Evans et al.   HUMAN GENE THERAPY

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

(2018) Zeming Wu et al.   Protein & Cell

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

(2018) Si Wang et al.   Cell Discovery

Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives

(2018) C. Randall Harrell et al.   BIOMEDICINE & PHARMACOTHERAPY

Aging of mesenchymal stem cells: Implication in regenerative medicine

(2018) Yueh-Hsun Kevin Yang   Regenerative Therapy

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA)

(2017) C.M. Bagi et al.   OSTEOARTHRITIS AND CARTILAGE

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

(2017) Congshan Sun et al.   STEM CELLS

Role of mesenchymal stem cells in osteoarthritis treatment

(2017) Ling Kong et al.   Journal of Orthopaedic Translation

Cellular senescence in aging and osteoarthritis

(2016) Wei Seong Toh et al.   Acta Orthopaedica

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

The Hippo pathway in cellular reprogramming and regeneration of different organs

(2016) Iván M Moya et al.   CURRENT OPINION IN CELL BIOLOGY

Tead and AP1 Coordinate Transcription and Motility

(2016) Xiangfan Liu et al.   Cell Reports

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

(2016) Lina Fu et al.   Protein & Cell

FOXD1 promotes breast cancer proliferation and chemotherapeutic drug resistance by targeting p27

(2015) Yi-Fan Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene therapy for human osteoarthritis: principles and clinical translation

(2015) Henning Madry et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Human bone marrow mesenchymal stromal/stem cells: current clinical applications and potential for hematology

(2015) Yasuo Miura   INTERNATIONAL JOURNAL OF HEMATOLOGY

Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stem cells and healthy aging

(2015) M. A. Goodell et al.   SCIENCE

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis

(2015) Hongtan Wu et al.   Nature Communications

Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study

(2014) R. Secunda et al.   CYTOTECHNOLOGY

Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation

(2014) Mahmood S Choudhery et al.   Journal of Translational Medicine

Resident mesenchymal progenitors of articular cartilage

(2014) Maria Elena Candela et al.   MATRIX BIOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Foxd1 is a mediator and indicator of the cell reprogramming process

(2014) Makito Koga et al.   Nature Communications

Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis

(2013) Yong-Gon Koh et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney

(2013) J. L. Fetting et al.   DEVELOPMENT

Mesenchymal Stem Cells Promote Hard-tissue Repair after Direct Pulp Capping

(2013) Maram Obeid et al.   JOURNAL OF ENDODONTICS

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Mesenchymal Stem Cells in Tissue Repair

(2013) Amy M. DiMarino et al.   Frontiers in Immunology

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

(2012) G. Ha et al.   GENOME RESEARCH

Brief Report: Long-Term Functional Engraftment of Mesenchymal Progenitor Cells in a Mouse Model of Accelerated Aging

(2012) Lakshman Singh et al.   STEM CELLS

FIMO: scanning for occurrences of a given motif

(2011) Charles E. Grant et al.   BIOINFORMATICS

Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells

(2011) Rika Yasuhara et al.   LABORATORY INVESTIGATION

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Identification and Clonal Characterisation of a Progenitor Cell Sub-Population in Normal Human Articular Cartilage

(2010) Rebecca Williams et al.   PLoS One

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Enhanced Tissue Integration During Cartilage Repair In Vitro Can Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge

(2009) Sophie J. Gilbert et al.   TISSUE ENGINEERING PART A

Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts

(2008) Shuanhu Zhou et al.   AGING CELL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

A rapid micro chromatin immunoprecipitation assay (ChIP)

(2008) John Arne Dahl et al.   Nature Protocols

Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(−) in adult bovine articular cartilage

(2008) I.M. Khan et al.   OSTEOARTHRITIS AND CARTILAGE

Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies

(2007) A. Stolzing et al.   MECHANISMS OF AGEING AND DEVELOPMENT