Post-traumatic osteoarthritis: from mouse models to clinical trials

Impact of Obesity and Knee Osteoarthritis on Morbidity and Mortality in Older Americans

(2013) Elena Losina et al.   ANNALS OF INTERNAL MEDICINE

Strontium ranelate: ready for clinical use as disease-modifying osteoarthritis drug?

(2013) Floris P J G Lafeber et al.   ANNALS OF THE RHEUMATIC DISEASES

MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity

(2013) Jinsoo Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

(2013) Y. Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis

(2013) M. Z. C. Ruan et al.   Science Translational Medicine

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Epidemiology of 6.6 Million Knee Injuries Presenting to United States Emergency Departments From 1999 Through 2008

(2012) Brett E. Gage et al.   ACADEMIC EMERGENCY MEDICINE

A novel disease-modifying osteoarthritis drug candidate targeting Runx1

(2012) Fumiko Yano et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

(2012) Jean-Yves Reginster et al.   ANNALS OF THE RHEUMATIC DISEASES

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium

(2012) Jean-Pierre Pelletier et al.   ANNALS OF THE RHEUMATIC DISEASES

Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice

(2012) Naoki Seito et al.   ARTHRITIS AND RHEUMATISM

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis

(2012) Gladys Valverde-Franco et al.   ARTHRITIS AND RHEUMATISM

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice

(2012) Tujun Weng et al.   ARTHRITIS AND RHEUMATISM

Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo

(2012) Annika Burleigh et al.   ARTHRITIS AND RHEUMATISM

TIMP2 deficient mice develop accelerated osteoarthritis via promotion of angiogenesis upon destabilization of the medial meniscus

(2012) Meng Mi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pathophysiology of peri-articular bone changes in osteoarthritis

(2012) H. Weinans et al.   BONE

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

(2012) Tadashi Hayami et al.   BONE

Prognosis and predictors of ACL reconstructions using the MOON cohort: A model for comparative effectiveness studies

(2012) Kurt P. Spindler et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Translatability scoring in drug development: eight case studies

(2012) Alexandra Wendler et al.   Journal of Translational Medicine

Meniscus pathology, osteoarthritis and the treatment controversy

(2012) Martin Englund et al.   Nature Reviews Rheumatology

What constitutes an “animal model of osteoarthritis” – the need for consensus?

(2012) C.B. Little et al.   OSTEOARTHRITIS AND CARTILAGE

Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep

(2012) M.A. Cake et al.   OSTEOARTHRITIS AND CARTILAGE

Altered Trabecular Bone Structure and Delayed Cartilage Degeneration in the Knees of Collagen VI Null Mice

(2012) Susan E. Christensen et al.   PLoS One

Procyanidin B3 Prevents Articular Cartilage Degeneration and Heterotopic Cartilage Formation in a Mouse Surgical Osteoarthritis Model

(2012) Hailati Aini et al.   PLoS One

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis

(2012) L. Lodewyckx et al.   RHEUMATOLOGY

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis

(2011) Eiji Kozawa et al.   ARTHRITIS AND RHEUMATISM

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Cost-Effectiveness Analysis of the Most Common Orthopaedic Surgery Procedures: Knee Arthroscopy and Knee Anterior Cruciate Ligament Reconstruction

(2011) James H. Lubowitz et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

(2011) J-H Ryu et al.   CELL DEATH AND DIFFERENTIATION

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

(2011) Cyrus Cooper et al.   CURRENT MEDICAL RESEARCH AND OPINION

Drug development in the light of translational science: shine or shade?

(2011) Martin Wehling   DRUG DISCOVERY TODAY

Emerging drugs for osteoarthritis

(2011) Gloria L Matthews et al.   EXPERT OPINION ON EMERGING DRUGS

Injury prevention in child death review: child pedestrian fatalities

(2011) E. Desapriya et al.   INJURY PREVENTION

Cytokine-like 1 Knock-out Mice (Cytl1−/−) Show Normal Cartilage and Bone Development but Exhibit Augmented Osteoarthritic Cartilage Destruction

(2011) Jimin Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-traumatic osteoarthritis: Improved understanding and opportunities for early intervention

(2011) Donald D. Anderson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Proteinase-activated Receptor-2 Gene Disruption Limits the Effect of Osteoarthritis on Cartilage in Mice: A Novel Target in Joint Degradation

(2011) NATHALIE AMIABLE et al.   JOURNAL OF RHEUMATOLOGY

Pain Mechanisms in Osteoarthritis: Understanding the Role of Central Pain and Current Approaches to Its Treatment

(2011) P. J. MEASE et al.   JOURNAL OF RHEUMATOLOGY

Definition and classification of early osteoarthritis of the knee

(2011) Frank P. Luyten et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Cartilage biology in osteoarthritis—lessons from developmental biology

(2011) Andrew A. Pitsillides et al.   Nature Reviews Rheumatology

OARSI-FDA initiative: defining the disease state of osteoarthritis

(2011) N.E. Lane et al.   OSTEOARTHRITIS AND CARTILAGE

T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

(2011) P.-C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis

(2011) J.M. Jordan et al.   OSTEOARTHRITIS AND CARTILAGE

Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover

(2011) R.H. Nielsen et al.   OSTEOARTHRITIS AND CARTILAGE

IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis

(2011) L. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies

(2011) S.G. Muthuri et al.   OSTEOARTHRITIS AND CARTILAGE

The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review

(2011) D. Pereira et al.   OSTEOARTHRITIS AND CARTILAGE

Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus

(2011) B.C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE

What makes osteoarthritis painful? The evidence for local and central pain processing

(2011) N. Sofat et al.   RHEUMATOLOGY

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

(2011) E. R. Sampson et al.   Science Translational Medicine

Osteoarthritis subpopulations and implications for clinical trial design

(2011) Sita MA Bierma-Zeinstra et al.   ARTHRITIS RESEARCH & THERAPY

Descriptive Epidemiology of the Multicenter ACL Revision Study (MARS) Cohort

(2010) et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis

(2010) W. R. Ferrell et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling

(2010) A. Kadri et al.   ANNALS OF THE RHEUMATIC DISEASES

Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

(2010) Lin Xu et al.   ARTHRITIS AND RHEUMATISM

Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection

(2010) Gregory D. Jay et al.   ARTHRITIS AND RHEUMATISM

Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Confirmation by multivariate analysis that modulation of type ii collagen and aggrecan degradation pepti

(2010) Steven Settle et al.   ARTHRITIS AND RHEUMATISM

A computational/experimental platform for investigating three-dimensional puzzle solving of comminuted articular fractures

(2010) Thaddeus P. Thomas et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Is Cartilage Matrix Breakdown an Appropriate Therapeutic Target in Osteoarthritis – Insights from Studies of Aggrecan and Collagen Proteolysis?

(2010) Christopher B. Little et al.   CURRENT DRUG TARGETS

A Pathway and Approach to Biomarker Validation and Qualification for Osteoarthritis Clinical Trials

(2010) David J. Hunter et al.   CURRENT DRUG TARGETS

The translatability of animal models for clinical development: biomarkers and disease models

(2010) Alexandra Wendler et al.   CURRENT OPINION IN PHARMACOLOGY

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Reconstructive versus non-reconstructive treatment of anterior cruciate ligament insufficiency. A retrospective matched-pair long-term follow-up

(2010) Nikolaus A. Streich et al.   INTERNATIONAL ORTHOPAEDICS

The anatomical basis for a novel classification of osteoarthritis and allied disorders

(2010) Dennis McGonagle et al.   JOURNAL OF ANATOMY

Is elevated contact stress predictive of post-traumatic osteoarthritis for imprecisely reduced tibial plafond fractures?

(2010) Donald D. Anderson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The histological features of Anteromedial Gonarthrosis — The comparison of two grading systems in a human phenotype of osteoarthritis

(2010) Rajesh Rout et al.   KNEE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Muscle weakness, afferent sensory dysfunction and exercise in knee osteoarthritis

(2010) Ewa M. Roos et al.   Nature Reviews Rheumatology

Pharmacologic therapy for osteoarthritis—the era of disease modification

(2010) David J. Hunter   Nature Reviews Rheumatology

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

A Randomized Trial of Treatment for Acute Anterior Cruciate Ligament Tears

(2010) Richard B. Frobell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histopathology atlas of animal model systems – overview of guiding principles

(2010) T. Aigner et al.   OSTEOARTHRITIS AND CARTILAGE

OARSI recommendations for the management of hip and knee osteoarthritis

(2010) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

(2010) P.S. Chockalingam et al.   OSTEOARTHRITIS AND CARTILAGE

Histopathology grading systems for characterisation of human knee osteoarthritis – reproducibility, variability, reliability, correlation, and validity

(2010) R.G. Pearson et al.   OSTEOARTHRITIS AND CARTILAGE

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain

(2010) Kay E. McNamee et al.   PAIN

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

(2010) S. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

(2010) Martin K Lotz   ARTHRITIS RESEARCH & THERAPY

Enhanced cartilage regeneration in MIA/CD-RAP deficient mice

(2010) R Schmid et al.   Cell Death & Disease

Cost Analysis of Converting from Single-Bundle to Double-Bundle Anterior Cruciate Ligament Reconstruction

(2009) Robert H. Brophy et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

(2009) Shi-Lu Chia et al.   ARTHRITIS AND RHEUMATISM

Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice

(2009) Yuichiro Matsui et al.   ARTHRITIS AND RHEUMATISM

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

(2009) Carl R. Flannery et al.   ARTHRITIS AND RHEUMATISM

Developmental and osteoarthritic changes inCol6a1-knockout mice: Biomechanics of type VI collagen in the cartilage pericellular matrix

(2009) Leonidas G. Alexopoulos et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Is osteoarthritis a heterogeneous disease that can be stratified into subsets?

(2009) Jeffrey B. Driban et al.   CLINICAL RHEUMATOLOGY

A meta-analysis of the effect of neuromuscular training on the prevention of the anterior cruciate ligament injury in female athletes

(2009) Jae Ho Yoo et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Assessing the translatability of drug projects: what needs to be scored to predict success?

(2009) Martin Wehling   NATURE REVIEWS DRUG DISCOVERY

Cervical Spine Injury: Tiger Attack

(2009) Meredith Anderson et al.   ORTHOPEDICS

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

(2009) J.R. Connor et al.   OSTEOARTHRITIS AND CARTILAGE

ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization

(2009) A.M. Malfait et al.   OSTEOARTHRITIS AND CARTILAGE

Deficiency of tenascin-C delays articular cartilage repair in mice

(2009) N. Okamura et al.   OSTEOARTHRITIS AND CARTILAGE

C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2

(2009) Makoto Hirata et al.   PLoS One

Primary Osteoarthritis No Longer Primary: Three Subsets with Distinct Etiological, Clinical, and Therapeutic Characteristics

(2009) Gabriel Herrero-Beaumont et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease

(2009) Ian D Welch et al.   ARTHRITIS RESEARCH & THERAPY

Prevalence of Tibiofemoral Osteoarthritis 15 Years after Nonoperative Treatment of Anterior Cruciate Ligament Injury

(2008) Paul Neuman et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis

(2008) A. Orlandi et al.   AMINO ACIDS

Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse

(2008) Benjamin D. Ward et al.   ARTHRITIS AND RHEUMATISM

Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis

(2008) A. Kadri et al.   ARTHRITIS AND RHEUMATISM

The risk for a cruciate ligament injury of the knee in adolescents and young adults: a population-based cohort study of 46 500 people with a 9 year follow-up

(2008) J Parkkari et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Incidence of anterior cruciate ligament injury and other knee ligament injuries: A national population-based study

(2008) Simon M. Gianotti et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

ADAMTS5−/− mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes

(2008) S.M. Botter et al.   OSTEOARTHRITIS AND CARTILAGE