The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis

Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways

(2014) H. Ogawa et al.   GENES & DEVELOPMENT

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes

(2014) C.L. Thompson et al.   OSTEOARTHRITIS AND CARTILAGE

Periodic Mechanical Stress Stimulates the FAK Mitogenic Signal in Rat Chondrocytes Through ERK1/2 Activity

(2013) Wenwei Liang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix

(2013) Tonia L Vincent   CURRENT OPINION IN PHARMACOLOGY

Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers

(2013) Josef A. Stolberg-Stolberg et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Replication of chronic abnormal cartilage loading by medial meniscus destabilization for modeling osteoarthritis in the rabbit knee in vivo

(2013) Marut Arunakul et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation

(2013) Amy L. McNulty et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

High resistance of the mechanical properties of the chondrocyte pericellular matrix to proteoglycan digestion by chondroitinase, aggrecanase, or hyaluronidase

(2013) Rebecca E. Wilusz et al.   Journal of the Mechanical Behavior of Biomedical Materials

Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage

(2013) R.E. Wilusz et al.   OSTEOARTHRITIS AND CARTILAGE

Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models

(2012) Carole Bougault et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo

(2012) Annika Burleigh et al.   ARTHRITIS AND RHEUMATISM

Biomechanical factors in osteoarthritis

(2012) Farshid Guilak   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes

(2012) Angus K. T. Wann et al.   FASEB JOURNAL

Diurnal variations in articular cartilage thickness and strain in the human knee

(2012) Jeremy L. Coleman et al.   JOURNAL OF BIOMECHANICS

Depth-dependent anisotropy of the micromechanical properties of the extracellular and pericellular matrices of articular cartilage evaluated via atomic force microscopy

(2012) Morgan A. McLeod et al.   JOURNAL OF BIOMECHANICS

Changes in chondrocyte gene expression following in vitro impaction of porcine articular cartilage in an impact injury model

(2012) Melissa S. Ashwell et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage

(2012) R. E. Wilusz et al.   Journal of the Royal Society Interface

A biomechanical role for perlecan in the pericellular matrix of articular cartilage

(2012) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation

(2012) Jessica L. Allen et al.   MOLECULAR BIOLOGY OF THE CELL

Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes

(2012) T. Saito et al.   OSTEOARTHRITIS AND CARTILAGE

Dynamic Compression of Chondrocyte-Agarose Constructs Reveals New Candidate Mechanosensitive Genes

(2012) Carole Bougault et al.   PLoS One

Proteinase-activated Receptor-2 Gene Disruption Limits the Effect of Osteoarthritis on Cartilage in Mice: A Novel Target in Joint Degradation

(2011) NATHALIE AMIABLE et al.   JOURNAL OF RHEUMATOLOGY

Subchondral bone changes in three different canine models of osteoarthritis

(2011) K. Kuroki et al.   OSTEOARTHRITIS AND CARTILAGE

Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis

(2011) C.-F. Chang et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanical Loading of Articular Cartilage Reduces IL-1-Induced Enzyme Expression

(2011) P. A. Torzilli et al.   Cartilage

Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: Age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice

(2010) Andrea L. Clark et al.   ARTHRITIS AND RHEUMATISM

Spatial Mapping of the Biomechanical Properties of the Pericellular Matrix of Articular Cartilage Measured In Situ via Atomic Force Microscopy

(2010) Eric M. Darling et al.   BIOPHYSICAL JOURNAL

An Axisymmetric Boundary Element Model for Determination of Articular Cartilage Pericellular Matrix Properties In Situ via Inverse Analysis of Chondron Deformation

(2010) Eunjung Kim et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

In vivo cartilage contact strains in patients with lateral ankle instability

(2010) Johanna E. Bischof et al.   JOURNAL OF BIOMECHANICS

Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes

(2010) Priyangi M Perera et al.   ARTHRITIS RESEARCH & THERAPY

Increased tibiofemoral cartilage contact deformation in patients with anterior cruciate ligament deficiency

(2009) Samuel K. Van de Velde et al.   ARTHRITIS AND RHEUMATISM

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

Developmental and osteoarthritic changes inCol6a1-knockout mice: Biomechanics of type VI collagen in the cartilage pericellular matrix

(2009) Leonidas G. Alexopoulos et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage

(2009) Kenneth W. Ng et al.   Cellular and Molecular Bioengineering

In vivo tibiofemoral cartilage deformation during the stance phase of gait

(2009) Fang Liu et al.   JOURNAL OF BIOMECHANICS

αv and β1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways

(2009) D.H. Chai et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage

(2009) P.A. Torzilli et al.   OSTEOARTHRITIS AND CARTILAGE

Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling

(2009) Jin Nam et al.   PLoS One

Temporal Effects of Impact on Articular Cartilage Cell Death, Gene Expression, Matrix Biochemistry, and Biomechanics

(2008) Roman M. Natoli et al.   ANNALS OF BIOMEDICAL ENGINEERING

Signal transduction pathways involving p38 MAPK, JNK, NFκB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1β and dynamic compression

(2008) T. T. Chowdhury et al.   INFLAMMATION RESEARCH

Synergistic and Additive Effects of Hydrostatic Pressure and Growth Factors on Tissue Formation

(2008) Benjamin D. Elder et al.   PLoS One