Mechanisms of Long Non-Coding RNAs in Cancers and Their Dynamic Regulations

Long noncoding RNA MPRL promotes mitochondrial fission and cisplatin chemosensitivity via disruption of pre-miRNA processing

(2019) Tian Tian et al.   CLINICAL CANCER RESEARCH

SATB2-AS1 suppresses colorectal carcinoma aggressiveness by inhibiting SATB2-dependent Snail transcription and epithelial-mesenchymal transition

(2019) Yi-Qing Wang et al.   CANCER RESEARCH

Epigenetic regulation of NAMPT by NAMPT-AS drives metastatic progression in triple-negative breast cancer

(2019) Hanwen Zhang et al.   CANCER RESEARCH

Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer

(2019) Shouping Xu et al.   Molecular Cancer

A long noncoding RNA distributed in both nucleus and cytoplasm operates in the PYCARD-regulated apoptosis by coordinating the epigenetic and translational regulation

(2019) Hui Miao et al.   PLoS Genetics

LncRNA HAND2‐AS1 promotes liver cancer stem cell self‐renewal via BMP signaling

(2019) Yanying Wang et al.   EMBO JOURNAL

Long noncoding RNA WDFY3‐AS2 suppresses tumor progression by acting as a competing endogenous RNA of microRNA‐18a in ovarian cancer

(2019) Weijia Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer

(2019) Peng Gu et al.   Molecular Cancer

Secondary Structural Model of Human MALAT1 Reveals Multiple Structure–Function Relationships

(2019) Phillip J. McCown et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

(2019) Wen Ni et al.   Molecular Cancer

ncRNA-Encoded Peptides or Proteins and Cancer

(2019) Jizhong Wang et al.   MOLECULAR THERAPY

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance

(2018) Assaf C. Bester et al.   CELL

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

(2018) Seung Woo Cho et al.   CELL

Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer

(2018) Xin Chen et al.   CLINICAL CANCER RESEARCH

LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer

(2018) Gang Zhang et al.   Molecular Cancer

LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis

(2018) Fengting Huang et al.   Molecular Cancer

LINC00470 Coordinates the Epigenetic Regulation of ELFN2 to Distract GBM Cell Autophagy

(2018) Changhong Liu et al.   MOLECULAR THERAPY

Estrogen receptor β promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network

(2018) Jie Ding et al.   ONCOGENE

LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation

(2018) Zhenzhen Chen et al.   ONCOGENE

Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7

(2018) Catherine D. Eichhorn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers

(2018) Mohamad Moustafa Ali et al.   Nature Communications

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

(2018) Yingchang Lu et al.   CANCER RESEARCH

The long noncoding RNA GAS8-AS1 suppresses hepatocarcinogenesis by epigenetically activating the tumor suppressor GAS8

(2018) Wenting Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling

(2018) Shreyas Lingadahalli et al.   MOLECULAR CANCER RESEARCH

lncRNA GCAWKR Promotes Gastric Cancer Development by Scaffolding the Chromatin Modification Factors WDR5 and KAT2A

(2018) Mingzhe Ma et al.   MOLECULAR THERAPY

Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria

(2018) Yang Wang et al.   NATURE CELL BIOLOGY

Insights into the noncoding RNA-encoded peptides

(2018) Jinchang Pan et al.   PROTEIN AND PEPTIDE LETTERS

Systematic identification of non-coding pharmacogenomic landscape in cancer

(2018) Yue Wang et al.   Nature Communications

NEAT1 paraspeckle promotes human hepatocellular carcinoma progression by strengthening IL-6/STAT3 signaling

(2018) Shuai Wang et al.   OncoImmunology

Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/β-catenin signaling pathway

(2018) Yang Luo et al.   CANCER LETTERS

LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation

(2018) Ming Shao et al.   Molecular Cancer

The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing

(2018) Michael A. Gordon et al.   MOLECULAR CARCINOGENESIS

Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence

(2018) Ben Sang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

(2018) Mahdieh Jadaliha et al.   PLoS Genetics

Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

(2017) Wei Lu et al.   Molecular Cancer

Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer

(2017) Hu YiRen et al.   Molecular Cancer

A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth

(2017) Jin-Zhou Huang et al.   MOLECULAR CELL

LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR-3182/MMP2 Axis

(2017) Kun-Peng Zhu et al.   MOLECULAR THERAPY

lncRNA HOXD-AS1 Regulates Proliferation and Chemo-Resistance of Castration-Resistant Prostate Cancer via Recruiting WDR5

(2017) Peng Gu et al.   MOLECULAR THERAPY

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

(2017) Flavia Michelini et al.   NATURE CELL BIOLOGY

A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression

(2017) Simon Grelet et al.   NATURE CELL BIOLOGY

Visualizing the secondary and tertiary architectural domains of lncRNA RepA

(2017) Fei Liu et al.   Nature Chemical Biology

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

(2017) Catherine M Phelan et al.   NATURE GENETICS

Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription

(2017) Michael S Werner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The crystal structure of the 5′ functional domain of the transcription riboregulator 7SK

(2017) Denise Martinez-Zapien et al.   NUCLEIC ACIDS RESEARCH

Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins

(2017) Joanna Sztuba-Solinska et al.   NUCLEIC ACIDS RESEARCH

LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells

(2017) H Xiong et al.   ONCOGENE

Global analysis of ribosome-associated noncoding RNAs unveils new modes of translational regulation

(2017) Jérémie Bazin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription

(2017) Michael S Werner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Upregulation of the lncRNA Meg3 induces autophagy to inhibit tumorigenesis and progression of epithelial ovarian carcinoma by regulating activity of ATG3

(2017) Yin-ling Xiu et al.   Oncotarget

The emerging epitranscriptomics of long noncoding RNAs

(2016) Andrew Shafik et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells

(2016) Serena Di Cecilia et al.   CANCER RESEARCH

The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer

(2016) Zhongwei Li et al.   CELL DEATH AND DIFFERENTIATION

LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer

(2016) Aldema Sas‐Chen et al.   EMBO Molecular Medicine

Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy

(2016) L. Li et al.   MOLECULAR CANCER THERAPEUTICS

Long Non-coding RNA BGas Regulates the Cystic Fibrosis Transmembrane Conductance Regulator

(2016) Sheena M Saayman et al.   MOLECULAR THERAPY

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

(2016) Aifu Lin et al.   NATURE CELL BIOLOGY

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer

(2016) Haiyang Guo et al.   NATURE GENETICS

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

(2016) Carmen Adriaens et al.   NATURE MEDICINE

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression

(2016) Yashar S. Niknafs et al.   Nature Communications

TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer

(2015) Song-Fa Zhang et al.   Autophagy

HEPeak: an HMM-based exome peak-finding package for RNA epigenome sequencing data

(2015) Xiaodong Cui et al.   BMC GENOMICS

Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis

(2015) Taewan Kim et al.   JNCI-Journal of the National Cancer Institute

Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16

(2015) Rong Kong et al.   Molecular Cancer

HOTAIR Forms an Intricate and Modular Secondary Structure

(2015) Srinivas Somarowthu et al.   MOLECULAR CELL

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

(2015) Karoline B Kuchenbaecker et al.   NATURE GENETICS

Genome-wide significant risk associations for mucinous ovarian carcinoma

(2015) Linda E Kelemen et al.   NATURE GENETICS

A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature

(2015) Inma Gonzalez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs

(2015) Ashish Dhir et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

(2015) Yehoshua Enuka et al.   NUCLEIC ACIDS RESEARCH

Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit

(2015) Ye Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNAPCA3

(2015) Ahmad Salameh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pri sORF peptides induce selective proteasome-mediated protein processing

(2015) J. Zanet et al.   SCIENCE

A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature

(2015) Inma Gonzalez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs

(2015) Ashish Dhir et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing Xist RNA Structure in Cells Using Targeted Structure-Seq

(2015) Rui Fang et al.   PLoS Genetics

Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis

(2015) Jiayan Fan et al.   GENOME BIOLOGY

Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis

(2015) Taewan Kim et al.   JNCI-Journal of the National Cancer Institute

Autophagy-mediated regulation of macrophages and its applications for cancer

(2014) Peiwen Chen et al.   Autophagy

Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex

(2014) Q Ji et al.   BRITISH JOURNAL OF CANCER

PCAT-1 , a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer

(2014) John R. Prensner et al.   CANCER RESEARCH

A biochemical landscape of A-to-I RNA editing in the human brain transcriptome

(2014) M. Sakurai et al.   GENOME RESEARCH

Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance

(2014) Rémy Denzler et al.   MOLECULAR CELL

Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing

(2014) Holger Bierhoff et al.   MOLECULAR CELL

PVT1 dependence in cancer with MYC copy-number increase

(2014) Yuen-Yi Tseng et al.   NATURE

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

(2014) H Choudhry et al.   ONCOGENE

Expression and prognostic impact of lncRNAs in acute myeloid leukemia

(2014) Ramiro Garzon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDRL lncRNA Regulates the Processing of miR-484 Primary Transcript by Targeting miR-361

(2014) Kun Wang et al.   PLoS Genetics

Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

(2014) Yul W Yang et al.   eLife

Long non-coding RNAs as a source of new peptides

(2014) Jorge Ruiz-Orera et al.   eLife

p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

(2014) Michal Krawczyk et al.   eLife

Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

(2014) Pavan Kumar P et al.   eLife

Long non-coding RNAs: A new frontier in the study of human diseases

(2013) Xuefei Shi et al.   CANCER LETTERS

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer

(2013) Ken-ichi Takayama et al.   EMBO JOURNAL

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

(2013) Paul D P Pharoah et al.   NATURE GENETICS

Identifying RNA editing sites using RNA sequencing data alone

(2013) Gokul Ramaswami et al.   NATURE METHODS

On the classification of long non-coding RNAs

(2013) Lina Ma et al.   RNA Biology

Long non-coding RNAs as targets for cytosine methylation

(2013) Thomas Amort et al.   RNA Biology

Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA

(2013) N. Liu et al.   RNA

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

How to Activate a Gene: Decap Its Associated Noncoding RNA

(2012) Madhuvanthi Ramaiah et al.   MOLECULAR CELL

Decapping of Long Noncoding RNAs Regulates Inducible Genes

(2012) Sarah Geisler et al.   MOLECULAR CELL

Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome

(2012) Zhiyu Peng et al.   NATURE BIOTECHNOLOGY

Polyadenylation-Dependent Control of Long Noncoding RNA Expression by the Poly(A)-Binding Protein Nuclear 1

(2012) Yves B. Beaulieu et al.   PLoS Genetics

Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression

(2011) F. Aguilo et al.   CANCER RESEARCH

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

(2011) Kevin C. Wang et al.   NATURE

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq

(2010) Jing Zhao et al.   MOLECULAR CELL

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Common variants at 19p13 are associated with susceptibility to ovarian cancer

(2010) Kelly L Bolton et al.   NATURE GENETICS

Small Peptides Switch the Transcriptional Activity of Shavenbaby During Drosophila Embryogenesis

(2010) T. Kondo et al.   SCIENCE

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

Altered Nuclear Retention of mRNAs Containing Inverted Repeats in Human Embryonic Stem Cells: Functional Role of a Nuclear Noncoding RNA

(2009) Ling-Ling Chen et al.   MOLECULAR CELL

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

(2009) Honglin Song et al.   NATURE GENETICS

MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles

(2009) Yasnory T. F. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA