The PI3K/AKT/mTOR interactive pathway

Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF-MEK-ERK Pathway in Cancer

(2014) G. L. Johnson et al.   CLINICAL CANCER RESEARCH

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

(2014) Pengda Liu et al.   NATURE

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signaling mechanisms of the epithelial-mesenchymal transition

(2014) D. M. Gonzalez et al.   Science Signaling

Vulnerabilities of PTEN-TP53-Deficient Prostate Cancers to Compound PARP-PI3K Inhibition

(2014) E. Gonzalez-Billalabeitia et al.   Cancer Discovery

Rapid Induction of Apoptosis by PI3K Inhibitors Is Dependent upon Their Transient Inhibition of RAS-ERK Signaling

(2014) M. Will et al.   Cancer Discovery

PTEN Interacts with Histone H1 and Controls Chromatin Condensation

(2014) Zhu Hong Chen et al.   Cell Reports

The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer

(2014) Saliha Ece Acuner Ozbabacan et al.   PLoS Computational Biology

Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair

(2014) Akari Minami et al.   Frontiers in Oncology

INstruct: a database of high-quality 3D structurally resolved protein interactome networks

(2013) Michael J. Meyer et al.   BIOINFORMATICS

AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion

(2013) Seung-Keun Hong et al.   EXPERIMENTAL CELL RESEARCH

Tumor adaptation and resistance to RAF inhibitors

(2013) Piro Lito et al.   NATURE MEDICINE

Integrating Structure to Protein-Protein Interaction Networks That Drive Metastasis to Brain and Lung in Breast Cancer

(2013) H. Billur Engin et al.   PLoS One

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors

(2012) A. B. Turke et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer

(2012) T. Shimizu et al.   CLINICAL CANCER RESEARCH

Constructing structural networks of signaling pathways on the proteome scale

(2012) Guray Kuzu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response

(2012) Chuan-Dong Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation

(2012) J. Chung et al.   JOURNAL OF CELL SCIENCE

Interactome3D: adding structural details to protein networks

(2012) Roberto Mosca et al.   NATURE METHODS

G Protein-Coupled Receptor-Mediated Activation of p110  by G   Is Required for Cellular Transformation and Invasiveness

(2012) H. A. Dbouk et al.   Science Signaling

The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor

(2012) Jae-Kyung Won et al.   Journal of Molecular Cell Biology

Negative Feedback and Adaptive Resistance to the Targeted Therapy of Cancer

(2012) Sarat Chandarlapaty   Cancer Discovery

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils

(2011) Davide Torti et al.   EMBO Molecular Medicine

Human Proteome-scale Structural Modeling of E2–E3 Interactions Exploiting Interface Motifs

(2011) Gozde Kar et al.   JOURNAL OF PROTEOME RESEARCH

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

(2011) Alyssa L. Kennedy et al.   MOLECULAR CELL

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

(2011) Yi-Hung Ou et al.   MOLECULAR CELL

Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM

(2011) Nurcan Tuncbag et al.   Nature Protocols

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

(2011) V. S. Rodrik-Outmezguine et al.   Cancer Discovery

Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain

(2010) Anutosh Chakraborty et al.   CELL

Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status

(2010) Francesca Buontempo et al.   INVESTIGATIONAL NEW DRUGS

AKT regulates BRCA1 stability in response to hormone signaling

(2010) Andrew C. Nelson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mechanisms of Motility in Metastasizing Cells

(2010) Mahmut Yilmaz et al.   MOLECULAR CANCER RESEARCH

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

(2010) Pierre-Olivier Estève et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Struct2Net: a web service to predict protein-protein interactions using a structure-based approach

(2010) R. Singh et al.   NUCLEIC ACIDS RESEARCH

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

(2009) S. Wee et al.   CANCER RESEARCH

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

(2009) Tatsuya Kawase et al.   CELL

Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer

(2009) Suzana S. Couto et al.   DIFFERENTIATION

Synthetic lethal targeting ofPTENmutant cells with PARP inhibitors

(2009) Ana M. Mendes-Pereira et al.   EMBO Molecular Medicine

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

(2009) Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Towards inferring time dimensionality in protein–protein interaction networks by integrating structures: the p53 example

(2009) Nurcan Tuncbag et al.   Molecular BioSystems

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel Phosphatidylinositol 3-Kinase-dependent AKT/IκB Kinase α Pathway Targeting Activator Protein-1

(2008) Catherine M. Cahill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architectures and Functional Coverage of Protein–Protein Interfaces

(2008) Nurcan Tuncbag et al.   JOURNAL OF MOLECULAR BIOLOGY

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

PTEN: a new guardian of the genome

(2008) Y Yin et al.   ONCOGENE

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA