Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics
Authors
Keywords
-
Journal
EXPERT OPINION ON EMERGING DRUGS
Volume 23, Issue 4, Pages 331-347
Publisher
Informa UK Limited
Online
2018-11-12
DOI
10.1080/14728214.2018.1547706
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Bisphosphonates reduce the risk of knee replacement: we need more analyses!
- (2018) Hui-Zi Li et al. ANNALS OF THE RHEUMATIC DISEASES
- Development and use of biochemical markers in osteoarthritis
- (2018) Anne C. Bay-Jensen et al. CURRENT OPINION IN RHEUMATOLOGY
- Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and development
- (2018) Anne-Christine Bay-Jensen et al. DRUG DISCOVERY TODAY
- Recent advances in intra-articular drug delivery systems for osteoarthritis therapy
- (2018) Pierre Maudens et al. DRUG DISCOVERY TODAY
- The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis
- (2018) Erik Lindström et al. Journal of Translational Medicine
- The role of radiography and MRI for eligibility assessment in DMOAD trials of knee OA
- (2018) Frank W. Roemer et al. Nature Reviews Rheumatology
- TPX-100 leads to marked, sustained improvements in subjects with knee osteoarthritis: pre-clinical rationale and results of a controlled clinical trial
- (2018) D. McGuire et al. OSTEOARTHRITIS AND CARTILAGE
- Osteoarthritis and stem cell therapy in humans: a systematic review
- (2018) D.S. Jevotovsky et al. OSTEOARTHRITIS AND CARTILAGE
- Clinimetrics of ultrasound pathologies in osteoarthritis: systematic literature review and meta-analysis
- (2018) W.M. Oo et al. OSTEOARTHRITIS AND CARTILAGE
- Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials
- (2018) E.E. Vaysbrot et al. OSTEOARTHRITIS AND CARTILAGE
- Projected Burden of Osteoarthritis and Rheumatoid Arthritis in Australia: A Population-Level Analysis
- (2018) Ilana N. Ackerman et al. ARTHRITIS CARE & RESEARCH
- A Multicenter, Double-Blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of a Cell and Gene Therapy in Knee Osteoarthritis Patients
- (2018) Myung-Ku Kim et al. Human Gene Therapy Clinical Development
- The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review
- (2017) Christelle Nguyen et al. Expert Opinion On Drug Safety
- Bisphosphonate Use and the Risk of Undergoing Total Knee Arthroplasty in Osteoporotic Patients with Osteoarthritis
- (2017) Shau-Huai Fu et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study
- (2017) Y. Yazici et al. OSTEOARTHRITIS AND CARTILAGE
- Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study
- (2017) S.X. Wang et al. OSTEOARTHRITIS AND CARTILAGE
- The challenge of the definition of early symptomatic knee osteoarthritis: a proposal of criteria and red flags from an international initiative promoted by the Italian Society for Rheumatology
- (2017) Alberto Migliore et al. RHEUMATOLOGY INTERNATIONAL
- Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis
- (2017) Kim L. Bennell et al. Current Rheumatology Reports
- Effectiveness of intra-articular therapies in osteoarthritis: a literature review
- (2017) Peter Wehling et al. Therapeutic Advances in Musculoskeletal Disease
- Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives
- (2017) Wayne Yuk-wai Lee et al. Journal of Orthopaedic Translation
- Cost-Effectiveness of Different Forms of Intra-Articular Injections for the Treatment of Osteoarthritis of the Knee
- (2016) Jeffrey Rosen et al. ADVANCES IN THERAPY
- OP0095 Randomized, Placebo-Controlled Trial To Evaluate Clinical Efficacy and Structure Modifying Properties of Subcutaneous Etanercept (ETN) in Patients with Erosive Inflammatory Hand Osteoarthritis (OA)
- (2016) M. Kloppenburg et al. ANNALS OF THE RHEUMATIC DISEASES
- Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial
- (2016) Frank W. Roemer et al. BMC MUSCULOSKELETAL DISORDERS
- Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis
- (2016) Yingliang Wei et al. CONNECTIVE TISSUE RESEARCH
- Monoclonal antibodies for the treatment of osteoarthritis
- (2016) Shuang Zheng et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- An update on the up and coming therapies to treat osteoarthritis, a multifaceted disease
- (2016) Jorge A. Roman-Blas et al. EXPERT OPINION ON PHARMACOTHERAPY
- Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future
- (2016) M.A. Karsdal et al. OSTEOARTHRITIS AND CARTILAGE
- Safety of Repeated Injections of Sodium Hyaluronate (SUPARTZ) for Knee Osteoarthritis
- (2016) Raveendhara R. Bannuru et al. Cartilage
- An MRI Evaluation of Patients Who Underwent Treatment with a Cell-Mediated Gene Therapy for Degenerative Knee Arthritis: A Phase IIa Clinical Trial
- (2016) Jung Cho et al. Journal of Knee Surgery
- Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis
- (2015) Raveendhara R. Bannuru et al. ANNALS OF INTERNAL MEDICINE
- Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis
- (2015) Olivier Bruyère et al. DRUGS & AGING
- Emerging drugs for the treatment of knee osteoarthritis
- (2015) Shirley Pei-Chun Yu et al. EXPERT OPINION ON EMERGING DRUGS
- Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age
- (2015) Kahaer Abula et al. FEBS LETTERS
- Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?
- (2015) AS Siebuhr et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Plain radiography or magnetic resonance imaging (MRI): Which is better in assessing outcome in clinical trials of disease-modifying osteoarthritis drugs? Summary of a debate held at the World Congress of Osteoarthritis 2014
- (2015) Felix Eckstein et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- A Road Map to Commercialization of Cartilage Therapy in the United States of America
- (2015) BanuPriya Sridharan et al. TISSUE ENGINEERING PART B-REVIEWS
- Brief Report: Intraarticular Sprifermin Not Only Increases Cartilage Thickness, but Also Reduces Cartilage Loss: Location-Independent Post Hoc Analysis Using Magnetic Resonance Imaging
- (2015) Felix Eckstein et al. Arthritis & Rheumatology
- Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial
- (2014) X Chevalier et al. ANNALS OF THE RHEUMATIC DISEASES
- The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
- (2014) Marita Cross et al. ANNALS OF THE RHEUMATIC DISEASES
- Progress in Intra-Articular Drug Delivery Systems for Osteoarthritis
- (2014) Xiaoye Yang et al. CURRENT DRUG TARGETS
- Emerging Pathways and Promising Agents with Possible Disease Modifying Effect in Osteoarthritis Treatment
- (2014) Zdravko Jotanovic et al. CURRENT DRUG TARGETS
- The individual and socioeconomic impact of osteoarthritis
- (2014) David J. Hunter et al. Nature Reviews Rheumatology
- The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics
- (2014) D.P. Tonge et al. OSTEOARTHRITIS AND CARTILAGE
- OARSI guidelines for the non-surgical management of knee osteoarthritis
- (2014) T.E. McAlindon et al. OSTEOARTHRITIS AND CARTILAGE
- Total Hip Replacement for the Treatment of End Stage Arthritis of the Hip: A Systematic Review and Meta-Analysis
- (2014) Alexander Tsertsvadze et al. PLoS One
- Prevalence of knee pain and knee OA in southern Sweden and the proportion that seeks medical care
- (2014) A. Turkiewicz et al. RHEUMATOLOGY
- Trends in Prescription of Opioids From 2003-2009 in Persons With Knee Osteoarthritis
- (2014) Elizabeth A. Wright et al. ARTHRITIS CARE & RESEARCH
- Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial
- (2014) L. Stefan Lohmander et al. Arthritis & Rheumatology
- Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss
- (2013) Jean-Pierre Pelletier et al. ANNALS OF THE RHEUMATIC DISEASES
- Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative
- (2013) Laura L Laslett et al. ANNALS OF THE RHEUMATIC DISEASES
- The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
- (2013) M A Karsdal et al. ANNALS OF THE RHEUMATIC DISEASES
- Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial
- (2013) Takashi Nishii et al. CLINICAL RHEUMATOLOGY
- How to define responders in osteoarthritis
- (2013) Cyrus Cooper et al. CURRENT MEDICAL RESEARCH AND OPINION
- Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
- (2013) Ashish Sharma et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Advances and challenges in gene-based approaches for osteoarthritis
- (2013) Henning Madry et al. JOURNAL OF GENE MEDICINE
- Progress in intra-articular therapy
- (2013) Christopher H. Evans et al. Nature Reviews Rheumatology
- Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?
- (2013) E. Losina et al. OSTEOARTHRITIS AND CARTILAGE
- Diagnosis and Clinical Presentation of Osteoarthritis
- (2013) A. Abhishek et al. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
- Defining and mapping the person with osteoarthritis for population studies and public health
- (2013) E. Thomas et al. RHEUMATOLOGY
- MMP13 is a critical target gene during the progression of osteoarthritis
- (2013) Meina Wang et al. ARTHRITIS RESEARCH & THERAPY
- The Future of Osteoarthritis Therapeutics: Targeted Pharmacological Therapy
- (2013) A. Mobasheri Current Rheumatology Reports
- Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial
- (2012) Laura Louise Laslett et al. ANNALS OF THE RHEUMATIC DISEASES
- Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial
- (2012) Jean-Yves Reginster et al. ANNALS OF THE RHEUMATIC DISEASES
- Progression of osteoarthritis as a state of inertia
- (2012) David Felson et al. ANNALS OF THE RHEUMATIC DISEASES
- A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
- (2012) Marie-Pierre Hellio le Graverand et al. ANNALS OF THE RHEUMATIC DISEASES
- Biomechanical factors in osteoarthritis
- (2012) Farshid Guilak BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
- Prognostic biomarkers in osteoarthritis
- (2012) Mukundan Attur et al. CURRENT OPINION IN RHEUMATOLOGY
- Insights on Biology and Pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-Catenin, and NF-κB Pathways in Osteoarthritis
- (2012) Longhuo Wu et al. CURRENT PHARMACEUTICAL DESIGN
- Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
- (2012) Christopher J L Murray et al. LANCET
- Bone remodelling in osteoarthritis
- (2012) David B. Burr et al. Nature Reviews Rheumatology
- Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
- (2012) F. Berenbaum OSTEOARTHRITIS AND CARTILAGE
- Fibrodysplasia Induced in Dog Skin by a Matrix Metalloproteinase (MMP) Inhibitor—A Mechanistic Analysis
- (2012) Jonathan D. Tugwood et al. TOXICOLOGICAL SCIENCES
- American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
- (2012) Marc C. Hochberg et al. ARTHRITIS CARE & RESEARCH
- Lifetime Risk and Age at Diagnosis of Symptomatic Knee Osteoarthritis in the US
- (2012) Elena Losina et al. ARTHRITIS CARE & RESEARCH
- Platelet-rich plasma therapy - future or trend?
- (2012) Robinder S Dhillon et al. ARTHRITIS RESEARCH & THERAPY
- Healthcare Costs Associated with Osteoarthritis in US Patients
- (2012) T. Kim Le et al. Pain Practice
- Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)
- (2012) A. Guermazi et al. BMJ-British Medical Journal
- Clinical significance of bone changes in osteoarthritis
- (2012) Tuhina Neogi Therapeutic Advances in Musculoskeletal Disease
- Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification
- (2011) Gust Verbruggen et al. ANNALS OF THE RHEUMATIC DISEASES
- The effects of doxycycline on reducing symptoms in knee osteoarthritis: results from a triple-blinded randomised controlled trial
- (2011) G. F. Snijders et al. ANNALS OF THE RHEUMATIC DISEASES
- Subchondral bone as a key target for osteoarthritis treatment
- (2011) Santos Castañeda et al. BIOCHEMICAL PHARMACOLOGY
- Emerging drugs for osteoarthritis
- (2011) Gloria L Matthews et al. EXPERT OPINION ON EMERGING DRUGS
- The cost of drug development: A systematic review
- (2011) Steve Morgan et al. HEALTH POLICY
- Osteoarthritis: an update with relevance for clinical practice
- (2011) Johannes WJ Bijlsma et al. LANCET
- Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover
- (2011) R.H. Nielsen et al. OSTEOARTHRITIS AND CARTILAGE
- Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis
- (2011) M. Bellido et al. OSTEOARTHRITIS AND CARTILAGE
- Responsiveness and reliability of MRI in knee osteoarthritis: a meta-analysis of published evidence
- (2011) D.J. Hunter et al. OSTEOARTHRITIS AND CARTILAGE
- Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis
- (2011) E. R. Sampson et al. Science Translational Medicine
- Bisphosphonates for osteoarthritis
- (2011) David A Walsh et al. ARTHRITIS RESEARCH & THERAPY
- A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
- (2011) Stanley B Cohen et al. ARTHRITIS RESEARCH & THERAPY
- Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI
- (2010) L. M. Wildi et al. ANNALS OF THE RHEUMATIC DISEASES
- Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament
- (2010) Kenneth D. Brandt et al. ARTHRITIS AND RHEUMATISM
- Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
- (2010) Yuqing Zhang et al. ARTHRITIS AND RHEUMATISM
- Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes
- (2010) Bodil-Cecilie Sondergaard et al. BMC MUSCULOSKELETAL DISORDERS
- Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis
- (2010) David J Hunter et al. BMC MUSCULOSKELETAL DISORDERS
- Disease Modifying Osteoarthritis Drugs: Facing Development Challenges and Choosing Molecular Targets
- (2010) Marie-Pierre Hellio Le Graverand-Gastineau CURRENT DRUG TARGETS
- Anticytokine Therapy for Osteoarthritis
- (2010) Charles J. Malemud DRUGS & AGING
- Osteoarthritis and Absenteeism Costs: Evidence From US National Survey Data
- (2010) Harry Kotlarz et al. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
- Pharmacologic therapy for osteoarthritis—the era of disease modification
- (2010) David J. Hunter Nature Reviews Rheumatology
- A systematic review of ultrasonography in osteoarthritis
- (2009) H I Keen et al. ANNALS OF THE RHEUMATIC DISEASES
- Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment
- (2009) S. Bar-Yehuda et al. ARTHRITIS AND RHEUMATISM
- Role of Wnt-5A in interleukin-1β-induced matrix metalloproteinase expression in rabbit temporomandibular joint condylar chondrocytes
- (2009) Xianpeng Ge et al. ARTHRITIS AND RHEUMATISM
- Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study
- (2009) X. Chevalier et al. ARTHRITIS AND RHEUMATISM
- Insurer and out-of-pocket costs of osteoarthritis in the US: Evidence from national survey data
- (2009) Harry Kotlarz et al. ARTHRITIS AND RHEUMATISM
- A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models
- (2009) Vijaykumar M. Baragi et al. ARTHRITIS AND RHEUMATISM
- Drug development cost estimates hard to swallow
- (2009) R. Collier CANADIAN MEDICAL ASSOCIATION JOURNAL
- Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study
- (2009) Antonella Fioravanti et al. RHEUMATOLOGY INTERNATIONAL
- Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
- (2008) J-P Raynauld et al. ANNALS OF THE RHEUMATIC DISEASES
- The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study
- (2008) Ibrahim Gulhan et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- Expression of the calcitonin receptor, calcitonin receptor-like receptor, and receptor activity modifying proteins during osteoclast differentiation
- (2008) Susanne Granholm et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Direct and Indirect Costs of Pain Therapy for Osteoarthritis in an Insured Population in the United States
- (2008) Alan G. White et al. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
- How Close are We to Having Structure-Modifying Drugs Available?
- (2008) David J. Hunter et al. MEDICAL CLINICS OF NORTH AMERICA
- Joint space narrowing and Kellgren–Lawrence progression in knee osteoarthritis: an analytic literature synthesis
- (2008) P.S. Emrani et al. OSTEOARTHRITIS AND CARTILAGE
- The Role of Bone in Osteoarthritis Pathogenesis
- (2008) Steven R. Goldring RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
- MMPs as therapeutic targets—Still a viable option?
- (2007) B FINGLETON SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started