Osteoarthritis: A disease of the joint as an organ

Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

(2011) F. W. Roemer et al.   ANNALS OF THE RHEUMATIC DISEASES

The impact of knee and hip chondrocalcinosis on disability in older people: the ProVA Study from northeastern Italy

(2011) E. Musacchio et al.   ANNALS OF THE RHEUMATIC DISEASES

Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis

(2011) Svetlana Krasnokutsky et al.   ARTHRITIS AND RHEUMATISM

Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis

(2011) Sadaf Ashraf et al.   ARTHRITIS AND RHEUMATISM

Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis

(2011) Akihiko Hasegawa et al.   ARTHRITIS AND RHEUMATISM

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

NC4 Domain of Cartilage-specific Collagen IX Inhibits Complement Directly Due to Attenuation of Membrane Attack Formation and Indirectly through Binding and Enhancing Activity of Complement Inhibitors C4B-binding Protein and Factor H

(2011) Nikolina Kalchishkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Associations of Anatomical Measures from MRI with Radiographically Defined Knee Osteoarthritis Score, Pain, and Physical Functioning

(2011) MaryFran Sowers et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis

(2011) C. Pauli et al.   OSTEOARTHRITIS AND CARTILAGE

IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis

(2011) L. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive mechanically controlled lubrication mechanism found in articular joints

(2011) G. W. Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts

(2011) Jeroen Geurts et al.   RHEUMATOLOGY

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

(2011) Stanley B Cohen et al.   ARTHRITIS RESEARCH & THERAPY

Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis

(2010) S. Ashraf et al.   ANNALS OF THE RHEUMATIC DISEASES

Articular cartilage calcification in osteoarthritis: Insights into crystal-induced stress

(2010) Hang-Korng Ea et al.   ARTHRITIS AND RHEUMATISM

Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

(2010) Lin Xu et al.   ARTHRITIS AND RHEUMATISM

Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis

(2010) Kaisa E. Happonen et al.   ARTHRITIS AND RHEUMATISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage

(2010) Ann K. Rosenthal et al.   ARTHRITIS AND RHEUMATISM

Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms

(2010) Carla R. Scanzello et al.   ARTHRITIS AND RHEUMATISM

Contribution of Mineral to Bone Structural Behavior and Tissue Mechanical Properties

(2010) Eve Donnelly et al.   CALCIFIED TISSUE INTERNATIONAL

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

The anatomical basis for a novel classification of osteoarthritis and allied disorders

(2010) Dennis McGonagle et al.   JOURNAL OF ANATOMY

Type II Collagen Expression Is Regulated by Tissue-specific miR-675 in Human Articular Chondrocytes

(2010) Katarzyna A. Dudek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histological evaluation and comparison of the anteromedial and posterolateral bundle of the human anterior cruciate ligament of the osteoarthritic knee joint

(2010) Arata Watanabe et al.   KNEE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells

(2010) M. Endres et al.   OSTEOARTHRITIS AND CARTILAGE

Changes of human menisci in osteoarthritic knee joints

(2010) Y. Katsuragawa et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells

(2010) T. Tetsunaga et al.   OSTEOARTHRITIS AND CARTILAGE

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY

S100A8 and S100A9 in experimental osteoarthritis

(2010) Hala Zreiqat et al.   ARTHRITIS RESEARCH & THERAPY

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

(2010) Isabel García-Arnandis et al.   ARTHRITIS RESEARCH & THERAPY

Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study

(2009) P. G. Conaghan et al.   ANNALS OF THE RHEUMATIC DISEASES

DNA demethylation at specific CpG sites in theIL1Bpromoter in response to inflammatory cytokines in human articular chondrocytes

(2009) Ko Hashimoto et al.   ARTHRITIS AND RHEUMATISM

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The multicenter osteoarthritis study

(2009) Martin Englund et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Diagnostic Utility of Cytokine Biomarkers in the Evaluation of Acute Knee Pain

(2009) Jason M Cuellar et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease

(2009) C.R. Scanzello et al.   OSTEOARTHRITIS AND CARTILAGE

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis

(2009) M. Blagojevic et al.   OSTEOARTHRITIS AND CARTILAGE

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis

(2008) F Pessler et al.   ANNALS OF THE RHEUMATIC DISEASES

Wnt signaling and osteoarthritis

(2008) Frank P. Luyten et al.   BONE

Cruciate Ligaments in Arthritic Knees

(2008) Arun B. Mullaji et al.   JOURNAL OF ARTHROPLASTY

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR4 signaling in the regulation of stem cell migration and development

(2008) Richard J. Miller et al.   JOURNAL OF NEUROIMMUNOLOGY

Incidental Meniscal Findings on Knee MRI in Middle-Aged and Elderly Persons

(2008) Martin Englund et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum protein signatures detect early radiographic osteoarthritis

(2008) S.M. Ling et al.   OSTEOARTHRITIS AND CARTILAGE

Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology

(2008) Mihra S. Taljanovic et al.   SKELETAL RADIOLOGY

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

(2008) James Melrose et al.   ARTHRITIS RESEARCH & THERAPY

Cell death in osteoarthritis

(2008) Marcello Del Carlo et al.   Current Rheumatology Reports