Epigenetic modifications and human disease

Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome

(2011) Rocio G. Urdinguio et al.   Epigenetics

Nucleosome occupancy landscape and dynamics at mouse recombination hotspots

(2010) Irina V Getun et al.   EMBO REPORTS

Chromatin remodeling factor CHD5 is silenced by promoter CpG island hypermethylation in human cancer

(2010) Sonia Mulero-Navarro et al.   Epigenetics

Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer

(2010) Pedro P. Medina et al.   Epigenetics

Chromatin dynamics coupled to DNA repair

(2010) Dori Huertas et al.   Epigenetics

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

The Inherent Processivity of the Humande NovoMethyltransferase 3A (DNMT3A) Is Enhanced by DNMT3L

(2010) Celeste Holz-Schietinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1

(2010) W. Pan et al.   JOURNAL OF IMMUNOLOGY

A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation

(2010) Daniela Kleine-Kohlbrecher et al.   MOLECULAR CELL

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

(2010) Hong Ji et al.   NATURE

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Chromatin remodelling during development

(2010) Lena Ho et al.   NATURE

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

(2010) John P. Thomson et al.   NATURE

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Chromatin regulation by Brg1 underlies heart muscle development and disease

(2010) Calvin T. Hang et al.   NATURE

Relationship between nucleosome positioning and DNA methylation

(2010) Ramakrishna K. Chodavarapu et al.   NATURE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Epigenetic modifications as therapeutic targets

(2010) Theresa K Kelly et al.   NATURE BIOTECHNOLOGY

Tackling the epigenome: challenges and opportunities for collaboration

(2010) John S Satterlee et al.   NATURE BIOTECHNOLOGY

Genomics tools for unraveling chromosome architecture

(2010) Bas van Steensel et al.   NATURE BIOTECHNOLOGY

Discovery and characterization of chromatin states for systematic annotation of the human genome

(2010) Jason Ernst et al.   NATURE BIOTECHNOLOGY

Epigenetic modifications in pluripotent and differentiated cells

(2010) Alexander Meissner   NATURE BIOTECHNOLOGY

The NIH Roadmap Epigenomics Mapping Consortium

(2010) Bradley E Bernstein et al.   NATURE BIOTECHNOLOGY

Principles and challenges of genome-wide DNA methylation analysis

(2010) Peter W. Laird   NATURE REVIEWS GENETICS

Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure

(2010) Mehregan Movassagh et al.   PLoS One

Histone modification levels are predictive for gene expression

(2010) R. Karlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

siRNAs and DNA methylation: seedy epigenetics

(2010) Rebecca A. Mosher et al.   TRENDS IN PLANT SCIENCE

siRNA–Mediated Methylation of Arabidopsis Telomeres

(2010) Jan Vrbsky et al.   PLoS Genetics

Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

(2010) J. Raphael Gibbs et al.   PLoS Genetics

Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease

(2009) Dominique J. Verlaan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-Wide Views of Chromatin Structure

(2009) Oliver J. Rando et al.   Annual Review of Biochemistry

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

Recent advances in MeCP2 structure and functionThis paper is one of a selection of papers published in this Special Issue, entitled 29th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

(2009) Kristopher C. Hite et al.   Biochemistry and Cell Biology

Epigenetics and atherosclerosis

(2009) Mikko P. Turunen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

(2009) R. Garzon et al.   BLOOD

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

X inactivation and the complexities of silencing a sex chromosome

(2009) Jennifer Chow et al.   CURRENT OPINION IN CELL BIOLOGY

Epigenetics and assisted reproduction

(2009) Louise Wilkins-Haug   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Clinical and molecular overview of inherited disorders resulting from epigenomic dysregulation

(2009) Albertina De Sario   European Journal of Medical Genetics

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

(2009) B. M. Javierre et al.   GENOME RESEARCH

Phosphorylation of Histone H3 Thr-45 Is Linked to Apoptosis

(2009) Paul J. Hurd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1

(2009) Shima Nakanishi et al.   JOURNAL OF CELL BIOLOGY

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Chromatin mechanisms in genomic imprinting

(2009) Slim Kacem et al.   MAMMALIAN GENOME

Selective Anchoring of DNA Methyltransferases 3A and 3B to Nucleosomes Containing Methylated DNA

(2009) S. Jeong et al.   MOLECULAR AND CELLULAR BIOLOGY

Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

(2009) P. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

(2009) Mark A. Dawson et al.   NATURE

The logic of chromatin architecture and remodelling at promoters

(2009) Bradley R. Cairns   NATURE

Small RNAs in transcriptional gene silencing and genome defence

(2009) Danesh Moazed   NATURE

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Locking in on the human methylome

(2009) Benjamin P Berman et al.   NATURE BIOTECHNOLOGY

Sensitive digital quantification of DNA methylation in clinical samples

(2009) Meng Li et al.   NATURE BIOTECHNOLOGY

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

(2009) Sonia A Melo et al.   NATURE GENETICS

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

DNA methylation profiles in monozygotic and dizygotic twins

(2009) Zachary A Kaminsky et al.   NATURE GENETICS

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

Nutritional programming of the metabolic syndrome

(2009) Michael E. Symonds et al.   Nature Reviews Endocrinology

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Rethinking how DNA methylation patterns are maintained

(2009) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Epigenetic control in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   Nature Reviews Rheumatology

Developmental programming of CpG island methylation profiles in the human genome

(2009) Ravid Straussman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miR-24–mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells

(2009) Ashish Lal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

(2009) E J Noonan et al.   ONCOGENE

Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation

(2009) F V Jacinto et al.   ONCOGENE

The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells

(2009) S R Naidu et al.   ONCOGENE

Histone macroH2A isoforms predict the risk of lung cancer recurrence

(2009) J C Sporn et al.   ONCOGENE

The SWI/SNF complex and cancer

(2009) D Reisman et al.   ONCOGENE

Insulin Gene Expression Is Regulated by DNA Methylation

(2009) Akio Kuroda et al.   PLoS One

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

(2009) M. Berdasco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

(2009) P.-O. Esteve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DEVELOPMENTAL BIOLOGY: Pluripotent Chromatin State

(2009) A. S. Chi et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

X inactivation and disease

(2009) Ruben Agrelo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD)

(2009) Weihua Zeng et al.   PLoS Genetics

The Genetic Signatures of Noncoding RNAs

(2009) John S. Mattick   PLoS Genetics

Proteins that bind methylated DNA and human cancer: reading the wrong words

(2008) L Lopez-Serra et al.   BRITISH JOURNAL OF CANCER

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Dynamic Regulation of Nucleosome Positioning in the Human Genome

(2008) Dustin E. Schones et al.   CELL

Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation: An Epigenetic Study in Diabetes

(2008) F. Miao et al.   DIABETES

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

(2008) Makoto Tachibana et al.   EMBO JOURNAL

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

(2008) Yoko Ito et al.   HUMAN MOLECULAR GENETICS

MeCP2-dependent repression of an imprinted miR-184 released by depolarization

(2008) Tasuku Nomura et al.   HUMAN MOLECULAR GENETICS

Chromatin Remodeling in the Noncoding Repeat Expansion Diseases

(2008) Daman Kumari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of H3S10 Blocks the Access of H3K9 by Specific Antibodies and Histone Methyltransferase

(2008) Qing Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetics in evolution and disease

(2008) Manel Esteller   LANCET

Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

(2008) Daniel Zilberman et al.   NATURE

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

(2008) Thomas A Down et al.   NATURE BIOTECHNOLOGY

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

(2008) Jing Wang et al.   NATURE GENETICS

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Histone H3 tail clipping regulates gene expression

(2008) Helena Santos-Rosa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability

(2008) Heike C. Pieper et al.   NEUROBIOLOGY OF DISEASE

DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight

(2008) D. J. Weisenberger et al.   NUCLEIC ACIDS RESEARCH

Mecp2-Null Mice Provide New Neuronal Targets for Rett Syndrome

(2008) Rocio G. Urdinguio et al.   PLoS One

A microRNA DNA methylation signature for human cancer metastasis

(2008) A. Lujambio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE

Epigenetic connections between autoimmune disorders and haematological malignancies

(2008) Biola M. Javierre et al.   TRENDS IN IMMUNOLOGY

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics