DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

(2016) Giovanna Nalesso et al.   ANNALS OF THE RHEUMATIC DISEASES

The upstreams and downstreams of H3K79 methylation by DOT1L

(2016) Hanneke Vlaming et al.   CHROMOSOMA

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis

(2016) Martha C. Castaño-Betancourt et al.   PLoS Genetics

The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis

(2016) Mona Dvir-Ginzberg et al.   Current Rheumatology Reports

Mixed lineage rearranged leukaemia

(2015) Eytan M. Stein et al.   CURRENT OPINION IN HEMATOLOGY

Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2α

(2015) Wuyin Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

NF-κB activation impairs somatic cell reprogramming in ageing

(2015) Clara Soria-Valles et al.   NATURE CELL BIOLOGY

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

(2015) Chun-Wei Chen et al.   NATURE MEDICINE

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis

(2015) S. Thysen et al.   OSTEOARTHRITIS AND CARTILAGE

Reciprocal regulation by hypoxia-inducible factor-2α and the NAMPT-NAD + -SIRT axis in articular chondrocytes is involved in osteoarthritis

(2015) H. Oh et al.   OSTEOARTHRITIS AND CARTILAGE

XAV939 Inhibits Vascular Remodeling by Reducing Vascular Smooth Muscle Cells Proliferation in Hypertensive Rats

(2015) Wei Yang et al.   Journal of Biomaterials and Tissue Engineering

Regulation of Wnt Signaling Target Gene Expression by the Histone Methyltransferase DOT1L

(2014) Garrett S. Gibbons et al.   ACS Chemical Biology

Osteoarthritis research priorities: a report from a EULAR ad hoc expert committee

(2014) Philip G Conaghan et al.   ANNALS OF THE RHEUMATIC DISEASES

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

(2014) Aravind Basavapathruni et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Chondrocyte hypertrophy in skeletal development, growth, and disease

(2014) Margaret Man-Ger Sun et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

(2014) Aniruddha J. Deshpande et al.   CANCER CELL

Association Between Single Nucleotide Polymorphisms of DOT1L Gene and Risk of Knee Osteoarthritis in a Chinese Han Population

(2014) Yun Zhou et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo

(2014) H. Vlaming et al.   EMBO REPORTS

The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism

(2014) H. J. Kim et al.   Bone & Joint Research

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

TheDOT1Lrs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males

(2013) Evangelos Evangelou et al.   ANNALS OF THE RHEUMATIC DISEASES

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture

(2013) B. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

(2012) Odile Gabay et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

(2012) M. C. Castano Betancourt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The diverse functions of Dot1 and H3K79 methylation

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

(2010) M. Mohan et al.   GENES & DEVELOPMENT

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Characterization of the DOT1L Network: Implications of Diverse Roles for DOT1L

(2010) Geunyeong Park et al.   PROTEIN JOURNAL

The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

(2010) Tokameh Mahmoudi et al.   PLOS BIOLOGY

Sirtuin 1 Functionally and Physically Interacts with Disruptor of Telomeric Silencing-1 to Regulate α-ENaCTranscription in Collecting Duct

(2009) Dongyu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development

(2009) E. Bitoun et al.   JOURNAL OF NEUROSCIENCE

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Transcriptional targets of sirtuins in the coordination of mammalian physiology

(2008) Jerome N Feige et al.   CURRENT OPINION IN CELL BIOLOGY

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology

(2008) M. Geyer et al.   OSTEOARTHRITIS AND CARTILAGE