Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice

A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy

(2012) Ge Zhang et al.   NATURE MEDICINE

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL/6 mice

(2011) Chancie Bayer Knights et al.   PAIN

Age-Related Changes in the Musculoskeletal System and the Development of Osteoarthritis

(2010) Richard F. Loeser   CLINICS IN GERIATRIC MEDICINE

Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation

(2010) Lei Wei et al.   DEVELOPMENTAL BIOLOGY

Indian Hedgehog Roles in Post-natal TMJ Development and Organization

(2010) T. Ochiai et al.   JOURNAL OF DENTAL RESEARCH

Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis

(2010) Jeffrey D Peterson et al.   ARTHRITIS RESEARCH & THERAPY

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor

(2009) Yukiko Maeda et al.   BONE

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription

(2009) W. Wang et al.   DEVELOPMENT

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease

(2009) Ian D Welch et al.   ARTHRITIS RESEARCH & THERAPY

Expression Analysis of Barrett's Esophagus-Associated High-Grade Dysplasia in Laser Capture Microdissected Archival Tissue

(2008) E. Sabo et al.   CLINICAL CANCER RESEARCH

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

(2008) K. K. Mak et al.   DEVELOPMENT

Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity

(2008) Shinsuke Ohba et al.   DEVELOPMENTAL CELL

Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression

(2008) Kinglun Kingston Mak et al.   DEVELOPMENTAL CELL

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse

(2008) Robert J. Lipinski et al.   TOXICOLOGICAL SCIENCES

Genetics of osteoarthritis: early developmental clues to an old disease

(2008) Eline Slagboom et al.   Nature clinical practice. Rheumatology

Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreERT2 transgenic mice

(2007) M. Zhu et al.   OSTEOARTHRITIS AND CARTILAGE