The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression

Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist

(2020) Moritz Riedl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chondrogenic Differentiation from Induced Pluripotent Stem Cells Using Non-Viral Minicircle Vectors

(2020) Yeri Alice Rim et al.   Cells

Proteolytic Regulation of Parathyroid Hormone-Related Protein: Functional Implications for Skeletal Malignancy

(2019) Jeremy S. Frieling et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype

(2019) Manuel J. Del Rey et al.   Immunity & Ageing

Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage–A self-controlled model for studying the etiology and treatment of osteoarthritis

(2019) Xiang Zhao et al.   BONE

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

(2018) Brian O. Diekman et al.   AGING CELL

Targeting aging for disease modification in osteoarthritis

(2018) John A. Collins et al.   CURRENT OPINION IN RHEUMATOLOGY

Senescent cells and osteoarthritis: a painful connection

(2018) Ok Hee Jeon et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis

(2018) Manuela Minguzzi et al.   Oxidative Medicine and Cellular Longevity

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

(2018) Claire Vinatier et al.   Frontiers in Physiology

Application of Cord Blood and Cord Blood-derived Induced Pluripotent Stem Cells for Cartilage Regeneration

(2018) Yeri Alice Rim et al.   CELL TRANSPLANTATION

Design, cyclization, and optimization of MMP13–TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis

(2018) Wei Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Cord blood cell-derived iPSCs as a new candidate for chondrogenic differentiation and cartilage regeneration

(2017) Yoojun Nam et al.   Stem Cell Research & Therapy

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes

(2017) Weidong Zhang et al.   PLoS One

Vascular Endothelial Growth Factor in Cartilage Development and Osteoarthritis

(2017) Masashi Nagao et al.   Scientific Reports

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

(2016) Ming Xu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration

(2016) S. Ashraf et al.   OSTEOARTHRITIS AND CARTILAGE

The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation

(2016) Jianmei Li et al.   Stem Cells International

Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age

(2015) Kahaer Abula et al.   FEBS LETTERS

Aging-related inflammation in osteoarthritis

(2015) M.A. Greene et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanical Forces Induce Changes in VEGF and VEGFR-1/sFlt-1 Expression in Human Chondrocytes

(2014) Rainer Beckmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters

(2014) Chun-do Oh et al.   PLoS One

Intermittent PTHrP(1–34) Exposure Augments Chondrogenesis and Reduces Hypertrophy of Mesenchymal Stromal Cells

(2014) Jennifer Fischer et al.   STEM CELLS AND DEVELOPMENT

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

(2014) Didier Philipot et al.   ARTHRITIS RESEARCH & THERAPY

Osteoblast-Chondrocyte Interactions in Osteoarthritis

(2014) David M. Findlay et al.   Current Osteoporosis Reports

The modulation of the oxidative stress response in chondrocytes by Wip1 and its effect on senescence and dedifferentiation during in vitro expansion

(2013) Byung-Hyun Cha et al.   BIOMATERIALS

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

TGF-ß1 Enhances the BMP-2-Induced Chondrogenesis of Bovine Synovial Explants and Arrests Downstream Differentiation at an Early Stage of Hypertrophy

(2013) Nahoko Shintani et al.   PLoS One

PTHrP isoforms have differing effect on chondrogenic differentiation and hypertrophy of mesenchymal stem cells

(2012) Jong-Min Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

Repair of Large Animal Partial-Thickness Cartilage Defects Through Intraarticular Injection of Matrix-Rejuvenated Synovium-Derived Stem Cells

(2012) Ming Pei et al.   TISSUE ENGINEERING PART A

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

(2012) Mary B. Goldring   Therapeutic Advances in Musculoskeletal Disease

Mechanics of chondrocyte hypertrophy

(2011) C. C. van Donkelaar et al.   Biomechanics and Modeling in Mechanobiology

New Hope for the Treatment of Osteoarthritis Through Selective Inhibition of MMP-13

(2011) N.-G. Li et al.   CURRENT MEDICINAL CHEMISTRY

Oxidative stress induces senescence in chondrocytes

(2011) Anita Brandl et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Effects of transforming growth factor-β subtypes on in vitro cartilage production and mineralization of human bone marrow stromal-derived mesenchymal stem cells

(2011) F. L. J. Cals et al.   Journal of Tissue Engineering and Regenerative Medicine

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes

(2011) C.-Y. Huang et al.   RHEUMATOLOGY

Hypertrophy in Mesenchymal Stem Cell Chondrogenesis: Effect of TGF-β Isoforms and Chondrogenic Conditioning

(2010) Michael B. Mueller et al.   CELLS TISSUES ORGANS

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet

(2010) Jaime Uribarri et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1

(2010) A.L. McNulty et al.   OSTEOARTHRITIS AND CARTILAGE

Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders

(2010) Rita Dreier   ARTHRITIS RESEARCH & THERAPY

Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes

(2010) Feng-Cheng Liu et al.   ARTHRITIS RESEARCH & THERAPY

Role of p53 in human chondrocyte apoptosis in response to shear strain

(2009) Shingo Hashimoto et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

An Update of the Oxidation-Inflammation Theory of Aging: The Involvement of the Immune System in Oxi-Inflamm-Aging

(2009) Monica Fuente et al.   CURRENT PHARMACEUTICAL DESIGN

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Matrix Metalloprotease Inhibitors Suppress Initiation and Progression of Chondrogenic Differentiation of Mesenchymal Stromal Cells In Vitro

(2009) Helge Bertram et al.   STEM CELLS AND DEVELOPMENT

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

(2008) Michael Muller   ANTIOXIDANTS & REDOX SIGNALING

PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs

(2008) Young-Ju Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

(2008) K. K. Mak et al.   DEVELOPMENT

Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes

(2008) S.-S. Nah et al.   RHEUMATOLOGY

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13

(2008) David Long et al.   ARTHRITIS RESEARCH & THERAPY

Endochondral ossification: How cartilage is converted into bone in the developing skeleton

(2007) E.J. Mackie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY