Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

A Variant in MCF2L Is Associated with Osteoarthritis

(2011) Aaron G. Day-Williams et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DOT1L regulates dystrophin expression and is critical for cardiac function

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

(2010) E. Evangelou et al.   ANNALS OF THE RHEUMATIC DISEASES

Early mammalian erythropoiesis requires the Dot1L methyltransferase

(2010) Y. Feng et al.   BLOOD

Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development

(2010) Evan R Barry et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

(2010) M. Mohan et al.   GENES & DEVELOPMENT

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

(2010) H.J.M. Kerkhof et al.   OSTEOARTHRITIS AND CARTILAGE

The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

(2010) Tokameh Mahmoudi et al.   PLOS BIOLOGY

Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand

(2009) Evangelos Evangelou et al.   ARTHRITIS AND RHEUMATISM

GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data

(2009) Karol Estrada et al.   BIOINFORMATICS

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations

(2009) I. Meulenbelt et al.   HUMAN MOLECULAR GENETICS

Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966

(2009) Ulla Sovio et al.   PLoS Genetics

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections

(2008) R Dieguez-Gonzalez et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study

(2008) R B A Vaes et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations

(2008) A M Valdes et al.   ANNALS OF THE RHEUMATIC DISEASES

Wnt signaling and osteoarthritis

(2008) Frank P. Luyten et al.   BONE

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

(2008) JB Richards et al.   LANCET

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics

The additive effect of individual genes in predicting risk of knee osteoarthritis

(2007) A M Valdes et al.   ANNALS OF THE RHEUMATIC DISEASES