Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of LPS-induced nitric oxide production in intestinal cells by hydroxytyrosol and tyrosol metabolites: Insight into the mechanism of action

(2019) Gabriele Serreli et al.   FOOD AND CHEMICAL TOXICOLOGY

NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases

(2019) Gönül Kanigur Sultuybek et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats

(2019) Yutaka Yonezawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Olive oil polyphenols extracts inhibit inflammatory markers in J774A.1 murine macrophages and scavenge free radicals

(2018) Marwa Abdallah et al.   ACTA HISTOCHEMICA

Nrf2: Molecular and epigenetic regulation during aging

(2018) A. Silva-Palacios et al.   AGEING RESEARCH REVIEWS

Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis

(2018) Abdul-Rehman Phull et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates

(2018) Muhammad Imran et al.   JOURNAL OF FOOD SCIENCE

Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer

(2018) Shreena J. Desai et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Olive oil and prevention of chronic diseases: Summary of an International conference

(2018) F. Visioli et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Olive oil polyphenols reduce oxysterols -induced redox imbalance and pro-inflammatory response in intestinal cells

(2018) Gessica Serra et al.   Redox Biology

Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer

(2018) Nikos Koundouros et al.   Frontiers in Oncology

Oleocanthal Inhibits Catabolic and Inflammatory Mediators in LPS-Activated Human Primary Osteoarthritis (OA) Chondrocytes Through MAPKs/NF-κB Pathways

(2018) Morena Scotece et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration

(2018) Cynthia Barrera et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Extra-Virgin Olive Oil Rich in Polyphenolic Compounds Has Antioxidant Effects in Of1 Mice

(2018) María-Jesús Oliveras-López et al.   JOURNAL OF NUTRITION

Oxidative DNA Damage Is Prevented by Extracts of Olive Oil, Hydroxytyrosol, and Other Olive Phenolic Compounds in Human Blood Mononuclear Cells and HL60 Cells

(2018) Roberto Fabiani et al.   JOURNAL OF NUTRITION

Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

(2018) Monica Deiana et al.   Food & Function

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Tyrosol attenuates lipopolysaccharide-induced acute lung injury by inhibiting the inflammatory response and maintaining the alveolar capillary barrier

(2017) Yeon-Yong Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

(2017) Elisabetta Bigagli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation

(2017) Antonella Cusimano et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Antioxidant Effect of Natural Table Olives Phenolic Extract Against Oxidative Stress and Membrane Damage in Enterocyte-Like Cells

(2017) Gabriele Serreli et al.   JOURNAL OF FOOD SCIENCE

Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2017) Wenyan Sun et al.   NEUROPHARMACOLOGY

Extra-virgin olive oil phenols hydroxytyrosol and hydroxytyrosol acetate, down-regulate the production of mediators involved in joint erosion in human synovial cells

(2017) María Ángeles Rosillo et al.   Journal of Functional Foods

Hydroxytyrosol exerts an anti-inflammatory effect by suppressing Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus -induced mastitis in mice

(2017) Haichong Wu et al.   Journal of Functional Foods

Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation

(2017) Rodrigo Valenzuela et al.   Food & Function

Liver Protective Effects of Extra Virgin Olive Oil: Interaction between Its Chemical Composition and the Cell-signaling Pathways Involved in Protection

(2017) Sandra A. Soto-Alarcon et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice

(2016) Joohwee Kim et al.   Aging-US

Extra virgin olive oil phenolic extracts counteract the pro-oxidant effect of dietary oxidized lipids in human intestinal cells

(2016) Alessandra Incani et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary extra virgin olive oil attenuates kidney injury in pristane-induced SLE model via activation of HO-1/Nrf-2 antioxidant pathway and suppression of JAK/STAT, NF-κB and MAPK activation

(2016) Marina Aparicio-Soto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Olive Oil and the Hallmarks of Aging

(2016) Lucía Fernández del Río et al.   MOLECULES

The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds

(2016) Lisa Parkinson et al.   MOLECULES

Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects on fatty acid composition in liver and extrahepatic tissues

(2016) Miguel Angel Rincón-Cervera et al.   NUTRITION

Differential absorption and metabolism of hydroxytyrosol and its precursors oleuropein and secoiridoids

(2016) María-Carmen López de las Hazas et al.   Journal of Functional Foods

3,4-Dihydroxyphenylethanol alleviates early brain injury by modulating oxidative stress and Akt and nuclear factor-κB pathways in a rat model of subarachnoid hemorrhage

(2016) PENG FU et al.   Experimental and Therapeutic Medicine

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Phenolic Compounds, Antioxidant Activity, and Other Characteristics of Extra Virgin Olive Oils from Italian Autochthonous VarietiesTonda di Villacidro,Tonda di Cagliari,Semidana, andBosana

(2016) Carlo I. G. Tuberoso et al.   Journal of Chemistry

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hydroxytyrosol, a dietary phenolic compound forestalls the toxic effects of methylmercury-induced toxicity in IMR-32 human neuroblastoma cells

(2015) Vishnu Mohan et al.   ENVIRONMENTAL TOXICOLOGY

Dose effect on the uptake and accumulation of hydroxytyrosol and its metabolites in target tissues in rats

(2015) Maria-Carmen López de las Hazas et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis

(2015) Ilavarasi Kalaiselvan et al.   PHARMACEUTICAL BIOLOGY

The hydroxytyrosol-dependent increase of TNF-α in LPS-activated human monocytes is mediated by PGE2 and adenylate cyclase activation

(2015) R. Fuccelli et al.   TOXICOLOGY IN VITRO

Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells

(2015) Shoujiao Peng et al.   Food & Function

Influence of olive-derived hydroxytyrosol on the toll-like receptor 4-dependent inflammatory response of mouse peritoneal macrophages

(2014) Yohei Takeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways

(2014) Baolei Zhao et al.   CANCER LETTERS

Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels

(2014) Antonio Camargo et al.   FOOD CHEMISTRY

Chitooligosaccharides prevent osteopenia by promoting bone formation and suppressing bone resorption in ovariectomised rats: possible involvement of COX-2

(2014) Bingshu He et al.   NATURAL PRODUCT RESEARCH

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Extra virgin olive oil polyphenolic extracts downregulate inflammatory responses in LPS-activated murine peritoneal macrophages suppressing NFκB and MAPK signalling pathways

(2014) A. Cárdeno et al.   Food & Function

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

(2013) Vadim N. Gladyshev   ANTIOXIDANTS & REDOX SIGNALING

Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans

(2013) María-Jesús Oliveras-López et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Enhanced NF- B Activity Impairs Vascular Function Through PARP-1-, SP-1-, and COX-2-Dependent Mechanisms in Type 2 Diabetes

(2013) M. Kassan et al.   DIABETES

Tyrosol exhibits negative regulatory effects on LPS response and endotoxemia

(2013) Jing Lu et al.   FOOD AND CHEMICAL TOXICOLOGY

Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice

(2013) Ke Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice

(2013) Susana Sánchez-Fidalgo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Olive oil phenols and neuroprotection

(2013) Ali Reza Khalatbary   NUTRITIONAL NEUROSCIENCE

Dose-dependent metabolic disposition of hydroxytyrosol and formation of mercapturates in rats

(2013) Aristotelis Kotronoulas et al.   PHARMACOLOGICAL RESEARCH

Involvement of MAPK/NF-κB Signaling in the Activation of the Cholinergic Anti-Inflammatory Pathway in Experimental Colitis by Chronic Vagus Nerve Stimulation

(2013) Peng Sun et al.   PLoS One

Distribution of procyanidins and their metabolites in rat plasma and tissues in relation to ingestion of procyanidin-enriched or procyanidin-rich cocoa creams

(2012) Aida Serra et al.   EUROPEAN JOURNAL OF NUTRITION

Phenols of virgin olive oil protects nuclear DNA against oxidative damage in HeLa cells

(2012) Özlem Erol et al.   FOOD AND CHEMICAL TOXICOLOGY

Impact of olive oil phenolic concentration on human plasmatic phenolic metabolites

(2012) Laura Rubió et al.   FOOD CHEMISTRY

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging

(2012) Sarah J. Chapple et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Diet Rich in Olive Oil Phenolics Reduces Oxidative Stress in the Heart of SAMP8 Mice by Induction of Nrf2-Dependent Gene Expression

(2012) Banu Bayram et al.   REJUVENATION RESEARCH

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells

(2011) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

(2011) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis

(2011) P. Khanal et al.   CARCINOGENESIS

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil

(2011) S Cicerale et al.   CURRENT OPINION IN BIOTECHNOLOGY

Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model

(2011) Susana Sánchez-Fidalgo et al.   EUROPEAN JOURNAL OF NUTRITION

Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice

(2011) Ayako Hirota et al.   EXPERIMENTAL DERMATOLOGY

Antioxidant and Anti-Inflammatory Activities of Maillard Reaction Products Isolated from Sugar–Amino Acid Model Systems

(2011) Xiu-Min Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and anti-aging

(2011) Cheng Luo et al.   MEDICAL HYPOTHESES

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

(2011) Alyssa L. Kennedy et al.   MOLECULAR CELL

Activation of nuclear factor-kappa B signalling promotes cellular senescence

(2011) E Rovillain et al.   ONCOGENE

Olive oil hydroxytyrosol reduces toxicity evoked by acrylamide in human Caco-2 cells by preventing oxidative stress

(2011) Ildefonso Rodríguez-Ramiro et al.   TOXICOLOGY

Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches

(2010) E. Cevenini et al.   CURRENT PHARMACEUTICAL DESIGN

Direct analysis of glucuronidated metabolites of main olive oil phenols in human urine after dietary consumption of virgin olive oil

(2010) Olha Khymenets et al.   FOOD CHEMISTRY

Olive Oil Phenols Modulate the Expression of Metalloproteinase 9 in THP-1 Cells by Acting on Nuclear Factor-κB Signaling

(2010) Mario Dell’Agli et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells

(2010) Lu Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells

(2010) María Angeles Martín et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of olive oil and its fractions on oxidative stress and the liver's fatty acid composition in 2,4-Dichlorophenoxyacetic acid-treated rats

(2010) Amel Nakbi et al.   Nutrition & Metabolism

Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008

(2010) J. López-Miranda et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

NF-κB and cancer: how intimate is this relationship

(2009) Sahdeo Prasad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1

(2009) Giulia Corona et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemistry and Health of Olive Oil Phenolics

(2008) Sara Cicerale et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Lipopolysaccharide-Stimulated RAW 264.7 Macrophage Inducible Nitric Oxide Synthase and Nitric Oxide Production Is Decreased by an Omega-3 Fatty Acid Lipid Emulsion

(2008) Christopher Aldridge et al.   JOURNAL OF SURGICAL RESEARCH

Bioavailability of olive oil phenolic compounds in humans

(2008) R. de la Torre   INFLAMMOPHARMACOLOGY