Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer

Anti-inflammatory effect of astaxanthin in phthalic anhydride-induced atopic dermatitis animal model

(2018) Ju Ho Park et al.   EXPERIMENTAL DERMATOLOGY

Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression

(2017) Subramaniya Bharathi Raja et al.   FOOD AND CHEMICAL TOXICOLOGY

Lycopene rich extract from red guava ( Psidium guajava L.) displays anti-inflammatory and antioxidant profile by reducing suggestive hallmarks of acute inflammatory response in mice

(2017) Andreanne G. Vasconcelos et al.   FOOD RESEARCH INTERNATIONAL

Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway

(2017) Sandeep Shrestha et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effect of interaction of epigallocatechin gallate and flavonols on color alteration of simulative green tea infusion after thermal treatment

(2017) Qianying Dai et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The synergistic potential of various teas, herbs and therapeutic drugs in health improvement: a review

(2017) Florence Malongane et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Curcumin May (Not) Defy Science

(2017) Kathryn M. Nelson et al.   ACS Medicinal Chemistry Letters

A Realistic View on “The Essential Medicinal Chemistry of Curcumin”

(2017) Fatemeh Bahadori et al.   ACS Medicinal Chemistry Letters

Prostate cancer downregulated SIRP-α modulates apoptosis and proliferation through p38-MAPK/NF-κB/COX-2 signaling

(2017) Chen Yao et al.   Oncology Letters

Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

(2017) Balaji Krishnamachary et al.   Oncotarget

Pro-inflammatory Signaling in a 3D Organotypic Skin Model after Low LET Irradiation—NF-κB, COX-2 Activation, and Impact on Cell Differentiation

(2017) Anna Acheva et al.   Frontiers in Immunology

Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor

(2017) Paramahamsa Maturu et al.   NEOPLASIA

Tristetraprolin: a novel mediator of the anticancer properties of resveratrol

(2016) C. Li et al.   GENETICS AND MOLECULAR RESEARCH

Tricin, flavonoid from Njavara reduces inflammatory responses in hPBMCs by modulating the p38MAPK and PI3K/Akt pathways and prevents inflammation associated endothelial dysfunction in HUVECs

(2016) V. Shalini et al.   IMMUNOBIOLOGY

Src/Syk/IRAK1-targeted anti-inflammatory action of Torreya nucifera butanol fraction in lipopolysaccharide-activated RAW264.7 cells

(2016) Shi Hyoung Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

The effects of quercetin-loaded PLGA-TPGS nanoparticles on ultraviolet B-induced skin damages in vivo

(2016) Xianbing Zhu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Quercetin suppresses the migration and invasion in human colon cancer Caco-2 cells through regulating toll-like receptor 4/Nuclear Factor-kappa B pathway

(2016) Yucheng Song et al.   Pharmacognosy Magazine

Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models: A mechanistic insight

(2016) Girish Rai et al.   PHYTOMEDICINE

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

(2016) Nagendra Sastry Yarla et al.   SEMINARS IN CANCER BIOLOGY

The ω-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of β-catenin complex, inhibiting COX-2 through repressing NF-κB, and inducing 15-prostaglandin dehydrogenase

(2016) Young-Min Han et al.   Oncotarget

Is temperature an effect modifier of the association between green tea intake and gastric cancer risk?

(2016) Silvia Deandrea et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Interaction of Salicylates and the Other Nonsteroidal Anti-Inflammatory Agents With Breast Cancer Endocrine Treatment

(2015) Eugenia Ch Yiannakopoulou   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention

(2015) Alexandra M. Fajardo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Increased dietary levels of α-linoleic acid inhibit mammary tumor growth and metastasis

(2015) Marianela Vara-Messler et al.   EUROPEAN JOURNAL OF NUTRITION

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

(2015) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways

(2015) GUANGXIU WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Green Tea Lowers Hepatic COX-2 and Prostaglandin E2 in Rats with Dietary Fat-Induced Nonalcoholic Steatohepatitis

(2015) Min-Yu Chung et al.   JOURNAL OF MEDICINAL FOOD

Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line

(2015) Akhilendra Kumar Maurya et al.   MOLECULAR BIOLOGY REPORTS

Mechanism of anti-inflammatory effect of tricin, a flavonoid isolated from Njavara rice bran in LPS induced hPBMCs and carrageenan induced rats

(2015) V. Shalini et al.   MOLECULAR IMMUNOLOGY

α-Linolenic Fatty Acid Supplementation Decreases Tumor Growth and Cachexia Parameters in Walker 256 Tumor-Bearing Rats

(2015) Dalton Luiz Schiessel et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Intestinal anti-inflammatory activity ofSasa quelpaertensisleaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells

(2015) Kyung-Mi Kim et al.   Nutrition Research and Practice

Epigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cells

(2015) JINGLI SHI et al.   ONCOLOGY REPORTS

Anti-inflammatory potential of carotenoidmeso-zeaxanthin and its mode of action

(2015) A. P. Firdous et al.   PHARMACEUTICAL BIOLOGY

Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity

(2015) Ina Willenberg et al.   PLoS One

A potential role of PUFAs and COXIBs in cancer chemoprevention

(2015) Marianela Vara-Messler et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Growth Inhibitory Effect of Polyunsaturated Fatty Acids (PUFAs) on Colon Cancer Cells via Their Growth Inhibitory Metabolites and Fatty Acid Composition Changes

(2015) Chengcheng Zhang et al.   PLoS One

Los polifenoles del vino ejercen su efecto antineoplásico sobre la línea celular PC-3 andrógeno resistente a través de la inhibición de la actividad transcripcional del promotor de COX-2 mediada por NF-kβ

(2014) A. Ferruelo et al.   Actas Urologicas Espanolas

α-Linolenic acid: Nutraceutical, pharmacological and toxicological evaluation

(2014) Kyu-Bong Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

I B  Is a Key Regulator of B Cell Expansion by Providing Negative Feedback on cRel and RelA in a Stimulus-Specific Manner

(2014) B. N. Alves et al.   JOURNAL OF IMMUNOLOGY

Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells

(2014) Myung-Hoon Chung et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Role of Ferulic Acid in the Amelioration of Ionizing Radiation Induced Inflammation: A Murine Model

(2014) Ujjal Das et al.   PLoS One

Resveratrol Modulates Cytokine-Induced JAK/STAT Activation More Efficiently than 5-Aminosalicylic Acid: An In Vitro Approach

(2014) Diana Serra et al.   PLoS One

Complementary and alternative medicine use among patients with thoracic malignancies

(2014) Rashmi S. Bismark et al.   SUPPORTIVE CARE IN CANCER

Meta-analysis of nonsteroidal anti-inflammatory drug intake and prostate cancer risk

(2014) Xiao Wang et al.   World Journal of Surgical Oncology

Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1, -3 and p38 MAPK

(2013) Morgana Rodrigues Guimarães et al.   ARCHIVES OF ORAL BIOLOGY

Dietary Polyphenols Suppress Elevated Levels of Proinflammatory Mediators and Aromatase in the Mammary Gland of Obese Mice

(2013) K. Subbaramaiah et al.   Cancer Prevention Research

Structural modeling and simulation studies of human cyclooxygenase (COX) isozymes with selected terpenes: Implications in drug designing and development

(2013) Swati Singh et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Anti-inflammatory Phytochemicals for Chemoprevention of Colon Cancer

(2013) Venkateshwar Madka et al.   CURRENT CANCER DRUG TARGETS

Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol

(2013) Hung-Yun Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Involvement of Nuclear Factor κB (NF-κB) in the Downregulation of Cyclo-Oxygenase-2 (COX-2) by Genistein in Gastric Cancer Cells

(2013) Y-S Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Radical Scavenging Activity-Based and AP-1-Targeted Anti-Inflammatory Effects of Lutein in Macrophage-Like and Skin Keratinocytic Cells

(2013) Jueun Oh et al.   MEDIATORS OF INFLAMMATION

Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: Partial mediation by the transcription factor NFAT1

(2013) Weiqi Dai et al.   MOLECULAR CARCINOGENESIS

Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways

(2013) Hsiao-Yun Lin et al.   NEUROBIOLOGY OF AGING

Green tea polyphenol, (−)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting β-catenin signaling

(2013) Tripti Singh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prevalence and Correlates of Postdiagnosis Initiation of Complementary and Alternative Medicine Among Patients at a Comprehensive Cancer Center

(2013) Adam Perlman et al.   Journal of Oncology Practice

Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis

(2012) Marieke GM Braem et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer

(2012) Egeria Scoditti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecules of Natural Origin, Semi-synthesis and Synthesis with Anti-Inflammatory and Anticancer Utilities

(2012) A. M. Lourenco et al.   CURRENT PHARMACEUTICAL DESIGN

Chemoprevention with Phytonutrients and Microalgae Products in Chronic Inflammation and Colon Cancer

(2012) Elena Talero et al.   CURRENT PHARMACEUTICAL DESIGN

Resveratrol suppresses 4-hydroxyestradiol-induced transformation of human breast epithelial cells by blocking IκB kinaseβ-NF-κB signalling

(2012) Sin-Aye Park et al.   FREE RADICAL RESEARCH

IKK biology

(2012) Fei Liu et al.   IMMUNOLOGICAL REVIEWS

Green Tea and Lung Cancer

(2012) Heidi Fritz et al.   INTEGRATIVE CANCER THERAPIES

Concomitant consumption of lycopene and fish oil inhibits tumor growth and progression in a mouse xenograft model of colon cancer

(2012) Feng-Yao Tang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin Attenuates TNF-Induced Inflammation in Hepatic Cells by Inhibiting the NF-κB Pathway

(2012) Ana Belén Granado-Serrano et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Long-chain fatty acids and inflammation

(2012) Philip C. Calder   PROCEEDINGS OF THE NUTRITION SOCIETY

Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin

(2012) Fei Ye   WORLD JOURNAL OF GASTROENTEROLOGY

Resveratrol and apoptosis

(2011) Hung-Yun Lin et al.   Annals of the New York Academy of Sciences

Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)

(2011) Kalimuthu Senthilkumar et al.   CELL BIOCHEMISTRY AND FUNCTION

Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines

(2011) Yumiko Yasui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Epidemiological studies of the association between tea drinking and primary liver cancer

(2011) Mélanie Fon Sing et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis

(2011) Anshoo Malhotra et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

How Many Cancer Patients Use Complementary and Alternative Medicine

(2011) Markus Horneber et al.   INTEGRATIVE CANCER THERAPIES

Consumption of Lycopene Inhibits the Growth and Progression of Colon Cancer in a Mouse Xenograft Model

(2011) Feng-Yao Tang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green and black tea in relation to gynecologic cancers

(2011) Lesley M. Butler et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Green Tea and Black Tea Consumption and Prostate Cancer Risk: An Exploratory Meta-Analysis of Observational Studies

(2011) Jusheng Zheng et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling

(2011) Xiangsheng Xiao et al.   PLoS One

Green Tea Catechins Reduce Invasive Potential of Human Melanoma Cells by Targeting COX-2, PGE2 Receptors and Epithelial-to-Mesenchymal Transition

(2011) Tripti Singh et al.   PLoS One

Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes

(2011) Laure Escoubet-Lozach et al.   PLoS Genetics

Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies

(2010) Jia-Yi Dong et al.   BREAST CANCER RESEARCH AND TREATMENT

Tea consumption and risk of ovarian cancer

(2010) Christina M. Nagle et al.   CANCER CAUSES & CONTROL

Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer

(2010) June M. Chan et al.   CANCER CAUSES & CONTROL

Inducible COX-2-dependent apoptosis in human ovarian cancer cells

(2010) C. Lin et al.   CARCINOGENESIS

Highly Purified Eicosapentaenoic Acid as Free Fatty Acids Strongly Suppresses Polyps in ApcMin/+ Mice

(2010) L. Fini et al.   CLINICAL CANCER RESEARCH

Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications

(2010) P. Palozza et al.   CURRENT MEDICINAL CHEMISTRY

Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: Prevention of NF-κB nuclear localization and down regulation of NF-κB and Cyclo-Oxygenase – 2 expression

(2010) Rajashree Krishnaswamy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabinein vitroand in orthotopic mouse model of human pancreatic cancer

(2010) Kuzhuvelil B. Harikumar et al.   INTERNATIONAL JOURNAL OF CANCER

Protective Effect of Quercetin against Arsenite-Induced COX-2 Expression by Targeting PI3K in Rat Liver Epithelial Cells

(2010) Kyung Mi Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ethyl Acetate Fraction of Adlay Bran Ethanolic Extract Inhibits Oncogene Expression and Suppresses DMH-Induced Preneoplastic Lesions of the Colon in F344 Rats through an Anti-inflammatory Pathway

(2010) Cheng-Pei Chung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin

(2010) Markus Griesser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and induction of cytosolic phospholipase A2 by TNF-α mediated through Nox2, MAPKs, NF-κB, and p300 in human tracheal smooth muscle cells

(2010) Chiang-Wen Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells

(2010) Vallabh O. Shah et al.   NATURAL PRODUCT RESEARCH

Prevalence of Complementary Medicine Use in Pediatric Cancer: A Systematic Review

(2010) F. L. Bishop et al.   PEDIATRICS

Cancer Prevention With Natural Compounds

(2010) Norleena P. Gullett et al.   SEMINARS IN ONCOLOGY

Green Tea Catechin Controls Apoptosis in Colon Cancer Cells by Attenuation of H2O2-Stimulated COX-2 Expression via the AMPK Signaling Pathway at Low-Dose H2O2

(2009) In-Ja Park et al.   Annals of the New York Academy of Sciences

Regulatory Effect of the AMPK-COX-2 Signaling Pathway in Curcumin-Induced Apoptosis in HT-29 Colon Cancer Cells

(2009) Yun-Kyoung Lee et al.   Annals of the New York Academy of Sciences

Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk

(2009) V. Fradet et al.   CLINICAL CANCER RESEARCH

AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin

(2009) Yun-Kyoung Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-κB in human tracheal smooth muscle cells

(2009) Shin-Ei Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2

(2009) Ponnuraj Nagendraprabhu et al.   INVESTIGATIONAL NEW DRUGS

Flavonoids Intake and Risk of Lung Cancer: A Meta-analysis

(2009) N.-P. Tang et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Green tea, black tea consumption and risk of lung cancer: A meta-analysis

(2009) Naping Tang et al.   LUNG CANCER

Soy Food Consumption and Risk of Prostate Cancer: A Meta-Analysis of Observational Studies

(2009) Ye Won Hwang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention

(2009) Wu-Yang Huang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: Pivotal roles of NF-κB and MAPK

(2009) Ok-Hwa Kang et al.   PHARMACOLOGICAL RESEARCH

Tricin—a potential multifunctional nutraceutical

(2009) Jian-Min Zhou et al.   PHYTOCHEMISTRY REVIEWS

Crosstalk via the NF-κB signaling system

(2008) Soumen Basak et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Anti-inflammatory effect of allylpyrocatechol in LPS-induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-κB pathway

(2008) Debjani Sarkar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Green tea consumption and risk of stomach cancer: A meta-analysis of epidemiologic studies

(2008) Seung Kwon Myung et al.   INTERNATIONAL JOURNAL OF CANCER

The role of vegetable and fruit consumption and other habits on survival following the diagnosis of oral cancer: a prospective study in Spain

(2008) M. Sandoval et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Prostanoids in health and disease: Fig. 1.

(2008) Emer M. Smyth et al.   JOURNAL OF LIPID RESEARCH

Resveratrol directly targets COX-2 to inhibit carcinogenesis

(2008) Tatyana A. Zykova et al.   MOLECULAR CARCINOGENESIS