Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

Redox Pioneer: Professor Gregg L. Semenza

(2010) Nanduri R. Prabhakar   ANTIOXIDANTS & REDOX SIGNALING

Redox Control of Protein–DNA Interactions: From Molecular Mechanisms to Significance in Signal Transduction, Gene Expression, and DNA Replication

(2010) Joseph Shlomai   ANTIOXIDANTS & REDOX SIGNALING

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Multiple Functions of Peroxiredoxins: Peroxidases, Sensors and Regulators of the Intracellular Messenger H2O2, and Protein Chaperones

(2010) Sue Goo Rhee et al.   ANTIOXIDANTS & REDOX SIGNALING

A Comparison of Thiol Peroxidase Mechanisms

(2010) Leopold Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Forkhead Box O as a Sensor, Mediator, and Regulator of Redox Signaling

(2010) Peter L.J. de Keizer et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Regulation of Redox Signaling by Selenoproteins

(2010) Wayne Chris Hawkes et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway

(2010) A Boutten et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of Wnt signalling via nucleoredoxin

(2010) Yosuke Funato et al.   FREE RADICAL RESEARCH

Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

(2010) Shruti Singh et al.   FREE RADICAL RESEARCH

Nrf2 target genes are induced under marginal selenium-deficiency

(2010) Mike Müller et al.   Genes and Nutrition

Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin

(2010) Ivano Condò et al.   HUMAN MOLECULAR GENETICS

Protein Phosphatase 2A Acts as a Mitogen-activated Protein Kinase Kinase Kinase 3 (MEKK3) Phosphatase to Inhibit Lysophosphatidic Acid-induced IκB Kinase β/Nuclear Factor-κB Activation

(2010) Wenjing Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleoredoxin Negatively Regulates Toll-like Receptor 4 Signaling via Recruitment of Flightless-I to Myeloid Differentiation Primary Response Gene (88)

(2010) Tatsuya Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Autoregulatory Loop between Nrf2 and Cul3-Rbx1 Controls Their Cellular Abundance

(2010) James W. Kaspar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone

(2010) V. Ashutosh Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice

(2010) Brahm H. Segal et al.   PLoS One

The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2

(2010) Jonathan Maher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

(2009) Gerardo Ferrer-Sueta et al.   ACS Chemical Biology

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Role of Hydrogen Peroxide in NF-κB Activation: From Inducer to Modulator

(2009) Virgínia Oliveira-Marques et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

(2009) Geoffrey Gloire et al.   ANTIOXIDANTS & REDOX SIGNALING

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A mechanism for the suppression of interleukin-1-induced nuclear factor κB activation by protein phosphatase 2Cη-2

(2009) Takeaki Henmi et al.   BIOCHEMICAL JOURNAL

Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-κB modulates glucocorticoid receptor and NF-κB signalling in HEK-293 cells

(2009) Anna-Maria G. Psarra et al.   BIOCHEMICAL JOURNAL

Thr435phosphorylation regulates RelA (p65) NF-κB subunit transactivation

(2009) John M. O'Shea et al.   BIOCHEMICAL JOURNAL

Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes

(2009) E. V. Kalinina et al.   BIOCHEMISTRY-MOSCOW

The labour pains of biochemical selenology: The history of selenoprotein biosynthesis

(2009) Leopold Flohé   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Catalytic mechanisms and specificities of glutathione peroxidases: Variations of a basic scheme

(2009) Stefano Toppo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Phosphorylase and the origin of reversible protein phosphorylation

(2009) Edmond H. Fischer   BIOLOGICAL CHEMISTRY

Unlike Esophageal Squamous Cells, Barrett's Epithelial Cells Resist Apoptosis by Activating the Nuclear Factor- B Pathway

(2009) K. Hormi-Carver et al.   CANCER RESEARCH

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Hypoxia inhibits induction of aryl hydrocarbon receptor activity in topminnow hepatocarcinoma cells in an ARNT-dependent manner

(2009) Carrie R. Fleming et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Toll-like receptor signaling in cell proliferation and survival

(2009) Xinyan Li et al.   CYTOKINE

Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination

(2009) Hui Geng et al.   EMBO REPORTS

Typical 2-Cys peroxiredoxins - structures, mechanisms and functions

(2009) Andrea Hall et al.   FEBS Journal

Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-κB signaling in the inflammatory process and aging

(2009) Kyung Jin Jung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin-related protein 14, a new member of the thioredoxin family with disulfide reductase activity: Implication in the redox regulation of TNF-α signaling

(2009) Woojin Jeong et al.   FREE RADICAL BIOLOGY AND MEDICINE

GCN5 is a required cofactor for a ubiquitin ligase that targets NF- B/RelA

(2009) X. Mao et al.   GENES & DEVELOPMENT

The resolution of inflammation: Anti-inflammatory roles for NF-κB

(2009) Toby Lawrence et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

(2009) Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Nuclear Factor-κB (NF-κB) Is a Novel Positive Transcriptional Regulator of the Oncogenic Wip1 Phosphatase

(2009) Julie M. Lowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Regulation of the Novel Toll-like ReceptorTlr13

(2009) Zhongcheng Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity

(2009) Thomas W. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant-induced Phosphorylation of Tyrosine 486 Leads to Rapid Nuclear Export of Bach1 That Allows Nrf2 to Bind to the Antioxidant Response Element and Activate Defensive Gene Expression

(2009) James W. Kaspar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Rafts and Caveolin-1 Coordinate Interleukin-1β (IL-1β)-dependent Activation of NFκB by Controlling Endocytosis of Nox2 and IL-1β Receptor 1 from the Plasma Membrane

(2009) Fredrick D. Oakley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

(2009) Suryakant K. Niture et al.   JOURNAL OF CELL SCIENCE

Peroxiredoxin 1 Stimulates Secretion of Proinflammatory Cytokines by Binding to TLR4

(2009) J. R. Riddell et al.   JOURNAL OF IMMUNOLOGY

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

(2009) Michelle H. W. Laird et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-κB Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury

(2009) Wei Jin et al.   MEDIATORS OF INFLAMMATION

The Guardian Recruits Cops: The p53-p21 Axis Delegates Prosurvival Duties to the Keap1-Nrf2 Stress Pathway

(2009) Michel B. Toledano   MOLECULAR CELL

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon

(2009) Anna Kipp et al.   MOLECULAR NUTRITION & FOOD RESEARCH

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

(2009) X. He et al.   MOLECULAR PHARMACOLOGY

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

(2009) Benjamin Yazdanpanah et al.   NATURE

WIP1 phosphatase is a negative regulator of NF-κB signalling

(2009) Joanne Chew et al.   NATURE CELL BIOLOGY

The function of NO-sensitive guanylyl cyclase: What we can learn from genetic mouse models

(2009) Andreas Friebe et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

(2009) A Arlt et al.   ONCOGENE

Cytoprotective Nrf2 Pathway Is Induced In Chronically Txnrd 1-Deficient Hepatocytes

(2009) Elena S. Suvorova et al.   PLoS One

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

(2009) Zheng Sun et al.   PLoS One

Transduction of Redox Signaling by Electrophile-Protein Reactions

(2009) T. K. Rudolph et al.   Science Signaling

Nrf2 signaling and cell survival

(2009) Suryakant K. Niture et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

Structural analysis of the complex of Keap1 with a prothymosin α peptide

(2008) Balasundaram Padmanabhan et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

Anti-Inflammatory and Proresolving Lipid Mediators

(2008) Charles N. Serhan et al.   Annual Review of Pathology-Mechanisms of Disease

Thiol Chemistry in Peroxidase Catalysis and Redox Signaling

(2008) Alberto Bindoli et al.   ANTIOXIDANTS & REDOX SIGNALING

The Dual Functions of Thiol-Based Peroxidases in H2O2 Scavenging and Signaling

(2008) Simon Fourquet et al.   ANTIOXIDANTS & REDOX SIGNALING

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

Signaling Components of Redox Active Endosomes: The Redoxosomes

(2008) Fredrick D. Oakley et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Compartmentalization of Redox Signaling Through NADPH Oxidase–Derived ROS

(2008) Masuko Ushio-Fukai   ANTIOXIDANTS & REDOX SIGNALING

Peroxynitrite as regulator of vascular prostanoid synthesis

(2008) Stefan Schildknecht et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347

(2008) Melanie Herscovitch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A functional link between housekeeping selenoproteins and phase II enzymes

(2008) Aniruddha Sengupta et al.   BIOCHEMICAL JOURNAL

Glutaredoxin systems

(2008) Christopher Horst Lillig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice

(2008) A. Banning et al.   CANCER RESEARCH

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

PPM1A and PPM1B act as IKKβ phosphatases to terminate TNFα-induced IKKβ-NF-κB activation

(2008) W SUN et al.   CELLULAR SIGNALLING

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

(2008) Girish Rachakonda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Antioxidant Activity of the Anti-Inflammatory Compound Ebselen: A Reversible Cyclization Pathway via Selenenic and Seleninic Acid Intermediates

(2008) Bani Kanta Sarma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Protein tyrosine phosphatases: structure-function relationships

(2008) Lydia Tabernero et al.   FEBS Journal

Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death

(2008) Yogesh C. Awasthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenium deficiency activates mouse liver Nrf2–ARE but vitamin E deficiency does not

(2008) Raymond F. Burk et al.   FREE RADICAL BIOLOGY AND MEDICINE

Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification

(2008) Florencia Irigoín et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

(2008) Anju Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

(2008) Patrick L. Apopa et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Phosphorylation and Dephosphorylation of Tyrosine 141 Regulate Stability and Degradation of INrf2

(2008) Abhinav K. Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynein Light Chain LC8 Negatively Regulates NF-κB through the Redox-dependent Interaction with IκBα

(2008) Yuyeon Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

(2008) Melanie Theodore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simvastatin activates Keap1/Nrf2 signaling in rat liver

(2008) Ioannis G. Habeos et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

A new APE1/Ref-1-dependent pathway leading to reduction of NF- B and AP-1, and activation of their DNA-binding activity

(2008) K. Ando et al.   NUCLEIC ACIDS RESEARCH

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

(2008) Young-Joon Surh et al.   PLANTA MEDICA

Nuclear Ubiquitin Ligases, NF- B Degradation, and the Control of Inflammation

(2008) G. Natoli et al.   Science Signaling

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS

IRAK1: A critical signaling mediator of innate immunity

(2007) Sridevi Gottipati et al.   CELLULAR SIGNALLING