NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells

Indoxyl Sulfate Downregulates Renal Expression of Klotho through Production of ROS and Activation of Nuclear Factor-ĸB

(2011) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indoxyl Sulfate Upregulates Expression of ICAM-1 and MCP-1 by Oxidative Stress-Induced NF-ĸB Activation

(2010) Zohra Tumur et al.   AMERICAN JOURNAL OF NEPHROLOGY

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate

(2010) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NF-κB p65 represses β-catenin-activated transcription of cyclin D1

(2010) Injoo Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reversal of aging by NFκB blockade

(2010) Adam S. Adler et al.   CELL CYCLE

Indoxyl Sulfate Stimulates Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells by Inducing Oxidative Stress Through Activation of the NADPH Oxidase-Nuclear Factor-κB Pathway

(2010) Natsumi Masai et al.   CIRCULATION JOURNAL

Indoxyl Sulfate-Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative Stress

(2010) M. Yu et al.   Clinical Journal of the American Society of Nephrology

Aldosterone/Mineralocorticoid Receptor Stimulation Induces Cellular Senescence in the Kidney

(2010) Yu-Yan Fan et al.   ENDOCRINOLOGY

Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?

(2010) S. Lekawanvijit et al.   EUROPEAN HEART JOURNAL

Indoxyl Sulfate Induces Leukocyte-Endothelial Interactions through Up-regulation of E-selectin

(2010) Shunsuke Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF B Promotes Inflammation, Coagulation, and Fibrosis in the Aging Glomerulus

(2010) J. E. Wiggins et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An Oral Sorbent, AST-120, Increases Klotho Expression and Inhibits Cell Senescence in the Kidney of Uremic Rats

(2009) Ayinuer Adijiang et al.   AMERICAN JOURNAL OF NEPHROLOGY

ROS and PDFG-β receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration

(2009) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of the immune response is a key feature of aging in mice

(2009) Thore C. Brink et al.   BIOGERONTOLOGY

RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair

(2009) Jingxin Wang et al.   EMBO REPORTS

Indoxyl Sulfate Promotes Proliferation of Human Aortic Smooth Muscle Cells by Inducing Oxidative Stress

(2009) Gulinuer Muteliefu et al.   JOURNAL OF RENAL NUTRITION

Indoxyl sulphate induces oxidative stress and the expression of osteoblast-specific proteins in vascular smooth muscle cells

(2009) G. Muteliefu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

(2008) A. Adijiang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION