Olive Oil and the Hallmarks of Aging

Oxidative DNA Damage Is Prevented by Extracts of Olive Oil, Hydroxytyrosol, and Other Olive Phenolic Compounds in Human Blood Mononuclear Cells and HL60 Cells

(2018) Roberto Fabiani et al.   JOURNAL OF NUTRITION

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population

(2015) Yian Gu et al.   AGE

The unfolded protein response and cellular senescence. A Review in the Theme: Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease

(2015) Olivier Pluquet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Oleic acid enhances the motility of umbilical cord blood derived mesenchymal stem cells through EphB2-dependent F-actin formation

(2015) Young Hyun Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inflammaging decreases adaptive and innate immune responses in mice and humans

(2015) Daniela Frasca et al.   BIOGERONTOLOGY

Correction of Mitochondrial Enzyme Activities in the Skeletal Muscles of Old Rats in Response to Addition of Olive Oil to the Ration

(2015) G. E. Bronnikov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Virgin olive oil rich in phenolic compounds modulates the expression of atherosclerosis-related genes in vascular endothelium

(2015) Eliana R. Meza-Miranda et al.   EUROPEAN JOURNAL OF NUTRITION

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

(2015) Hisham Qosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms

(2015) Andrea Di Francesco et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

(2015) S. Silva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Radical-scavenging Activity and Antioxidative Effects of Olive Leaf Components Oleuropein and Hydroxytyrosol in Comparison with Homovanillic Alcohol

(2015) Aya Umeno et al.   Journal of Oleo Science

Relationship Between Mitochondrial DNA Mutations and Aging. Estimation of Age-at-death

(2015) Sara C. Zapico et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

What olive oil for healthy ageing?

(2015) Anna Aiello et al.   MATURITAS

Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation

(2015) Daniel Arango et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases

(2015) Jose Rodríguez-Morató et al.   MOLECULES

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies

(2015) Mohammad A. Khanfar et al.   PHYTOTHERAPY RESEARCH

Consumption of Distinct Dietary Lipids during Early Pregnancy Differentially Modulates the Expression of microRNAs in Mothers and Offspring

(2015) Patricia Casas-Agustench et al.   PLoS One

Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib

(2015) Nickolay Neznanov et al.   Oncotarget

How does the Mediterranean diet promote cardiovascular health? Current progress toward molecular mechanisms

(2014) Dolores Corella et al.   BIOESSAYS

Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of Greek preadolescents

(2014) Sarah Voisin et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Phenolic compounds and antioxidant capacity of virgin olive oil

(2014) Ma Nieves Franco et al.   FOOD CHEMISTRY

Quantitative Measurement of Major Secoiridoid Derivatives in Olive Oil Using qNMR. Proof of the Artificial Formation of Aldehydic Oleuropein and Ligstroside Aglycon Isomers

(2014) Evangelia Karkoula et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Extra virgin olive oil intake delays the development of amyotrophic lateral sclerosis associated with reduced reticulum stress and autophagy in muscle of SOD1G93A mice

(2014) Sara Oliván et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ER Stress Response in Human Cellular Models of Senescence

(2014) Liliana Matos et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Methylation levels of the SCD1 gene promoter and LINE-1 repeat region are associated with weight change: An intervention study

(2014) Gracia María Martín-Núñez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genetic rejuvenation of old muscle

(2014) Mo Li et al.   NATURE

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Supplementation with N-3 Long-Chain Polyunsaturated Fatty Acids or Olive Oil in Men and Women with Renal Disease Induces Differential Changes in the DNA Methylation of FADS2 and ELOVL5 in Peripheral Blood Mononuclear Cells

(2014) Samuel P. Hoile et al.   PLoS One

Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study

(2014) M. Crous-Bou et al.   BMJ-British Medical Journal

Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis

(2014) P. C. Haycock et al.   BMJ-British Medical Journal

Olive oil in the prevention and treatment of osteoporosis after artificial menopause

(2014) Huilan Liu et al.   Clinical Interventions in Aging

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response

(2013) Dietlind Sommerweiss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extra-virgin olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1 anti-inflammatory activities

(2013) Soumaya Loued et al.   BRITISH JOURNAL OF NUTRITION

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

SNPs located at CpG sites modulate genome-epigenome interaction

(2013) Degui Zhi et al.   Epigenetics

Diet-dependent Alterations of Hepatic Scd1 Expression are Accompanied by Differences in Promoter Methylation

(2013) R. Schwenk et al.   HORMONE AND METABOLIC RESEARCH

Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial

(2013) S García-Calzón et al.   INTERNATIONAL JOURNAL OF OBESITY

Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex

(2013) Ji-Hong Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Individual Saturated and Monounsaturated Fatty Acids Trigger Distinct Transcriptional Networks in Differentiated 3T3-L1 Preadipocytes

(2013) Brittany Shaw et al.   Journal of Nutrigenetics and Nutrigenomics

Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes

(2013) Patrizia Rosignoli et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Astrogliopathology

(2013) Alexei Verkhratsky et al.   NEUROSCIENTIST

Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway

(2013) Andrzej Parzonko et al.   PHYTOMEDICINE

Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial

(2013) Martin de Bock et al.   PLoS One

Mediterranean Diet, Telomere Maintenance and Health Status among Elderly

(2013) Virginia Boccardi et al.   PLoS One

Diets Based on Virgin Olive Oil or Fish Oil but Not on Sunflower Oil Prevent Age-Related Alveolar Bone Resorption by Mitochondrial-Related Mechanisms

(2013) Pedro Bullon et al.   PLoS One

Evidence for impaired amyloid β clearance in Alzheimer's disease

(2013) Kristin R Wildsmith et al.   Alzheimers Research & Therapy

The Diagnostic and Prognostic Role of microRNA in Colorectal Cancer - a Comprehensive review

(2013) Haggi Mazeh et al.   Journal of Cancer

Review: a meta-analysis of GWAS and age-associated diseases

(2012) William R. Jeck et al.   AGING CELL

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Physical Activity, Sedentary Behavior, and Leukocyte Telomere Length in Women

(2012) M. Du et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Educational attainment and late life telomere length in the Health, Aging and Body Composition Study

(2012) Nancy Adler et al.   BRAIN BEHAVIOR AND IMMUNITY

Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial

(2012) Janice K. Kiecolt-Glaser et al.   BRAIN BEHAVIOR AND IMMUNITY

Socioeconomic factors and leukocyte telomere length in a multi-ethnic sample: Findings from the multi-ethnic study of atherosclerosis (MESA)

(2012) Judith E. Carroll et al.   BRAIN BEHAVIOR AND IMMUNITY

HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity

(2012) Wei-Chung Chiang et al.   CELL

CLOCK, PER2 and BMAL1 DNA Methylation: Association with Obesity and Metabolic Syndrome Characteristics and Monounsaturated Fat Intake

(2012) Fermín I. Milagro et al.   CHRONOBIOLOGY INTERNATIONAL

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Phenols of virgin olive oil protects nuclear DNA against oxidative damage in HeLa cells

(2012) Özlem Erol et al.   FOOD AND CHEMICAL TOXICOLOGY

Paternal age at birth is associated with offspring leukocyte telomere length in the nurses' health study

(2012) J. Prescott et al.   HUMAN REPRODUCTION

X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells

(2012) Ronald Allan M. Panganiban et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Direct Measurement of Oleocanthal and Oleacein Levels in Olive Oil by Quantitative 1H NMR. Establishment of a New Index for the Characterization of Extra Virgin Olive Oils

(2012) Evangelia Karkoula et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Modulation of Tau Protein Fibrillization by Oleocanthal

(2012) Maria Chiara Monti et al.   JOURNAL OF NATURAL PRODUCTS

Telomere length, oxidative stress, and antioxidant status in elderly men in Zutphen and Crete

(2012) Joyce M.J. de Vos-Houben et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans

(2012) Ana Cañuelo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and in Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells

(2012) Laura Zambonin et al.   Oxidative Medicine and Cellular Longevity

High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women

(2012) Olivia I. Okereke et al.   PLoS One

Stearoyl-CoA desaturase: rogue or innocent bystander?

(2012) Leanne Hodson et al.   PROGRESS IN LIPID RESEARCH

Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease

(2012) Adam Kline   Alzheimers Research & Therapy

Dietary oil modifies the plasma proteome during aging in the rat

(2011) Mónica Santos-González et al.   AGE

Mediterranean diet reduces senescence-associated stress in endothelial cells

(2011) Carmen Marin et al.   AGE

Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6

(2011) Christopher D. Green et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model

(2011) Susana Sánchez-Fidalgo et al.   EUROPEAN JOURNAL OF NUTRITION

Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways

(2011) Xuan Zou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Up-regulation of P-glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P-glycoprotein as a novel therapeutic target for Alzheimer's disease

(2011) Alaa H. Abuznait et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Oleuropein and derivatives from olives as Tau aggregation inhibitors

(2011) Anthony Daccache et al.   NEUROCHEMISTRY INTERNATIONAL

Melatonin and the Metabolic Syndrome: Physiopathologic and Therapeutical Implications

(2011) Daniel P. Cardinali et al.   NEUROENDOCRINOLOGY

The Crystal Structure of the Human Co-Chaperone P58IPK

(2011) Maria Svärd et al.   PLoS One

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

(2011) Maria Chiara Monti et al.   Food & Function

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

(2010) Fernando G. Osorio et al.   AGING CELL

Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil

(2010) Antonio Camargo et al.   BMC GENOMICS

SnapShot: The Unfolded Protein Response

(2010) R. Luke Wiseman et al.   CELL

Aging: ROS or TOR

(2010) Mikhail V Blagosklonny   CELL CYCLE

Aging of the innate immune system

(2010) Albert C Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial

(2010) Valentini Konstantinidou et al.   FASEB JOURNAL

Widespread and tissue specific age-related DNA methylation changes in mice

(2010) S. Maegawa et al.   GENOME RESEARCH

Oleic acid modulation of the immune response in wound healing: A new approach for skin repair

(2010) C.R. Cardoso et al.   IMMUNOBIOLOGY

Olive Oil Phenols Modulate the Expression of Metalloproteinase 9 in THP-1 Cells by Acting on Nuclear Factor-κB Signaling

(2010) Mario Dell’Agli et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Prediction of Extra Virgin Olive Oil Varieties through Their Phenolic Profile. Potential Cytotoxic Activity against Human Breast Cancer Cells

(2010) Jesús Lozano-Sánchez et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response

(2010) Hiroyuki Ariyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Tau at Thr212, Thr231, and Ser262Combined Causes Neurodegeneration

(2010) Alejandra D. Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008

(2010) J. López-Miranda et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow

(2010) R. Santiago-Mora et al.   OSTEOPOROSIS INTERNATIONAL

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Race/ethnicity and telomere length in the Multi-Ethnic Study of Atherosclerosis

(2009) Ana V. Diez Roux et al.   AGING CELL

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats

(2009) Khaled Hamden et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging – A Mini-Review

(2009) Stuart K. Calderwood et al.   GERONTOLOGY

Physical Activity, Diet, and Risk of Alzheimer Disease

(2009) Nikolaos Scarmeas   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antidiabetic and Antioxidant Effects of Hydroxytyrosol and Oleuropein from Olive Leaves in Alloxan-Diabetic Rats

(2009) Hedya Jemai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

(2009) Wenkai Li et al.   JOURNAL OF NEUROCHEMISTRY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin☆

(2009) Stefania Rigacci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice

(2009) William R. Swindell et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells

(2009) Xiaomei Zhang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Telomere Diseases

(2009) Rodrigo T. Calado et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circadian Rhythm of Clock Genes in Human Adipose Explants

(2009) Cecilia Gómez-Santos et al.   Obesity

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study

(2008) A. Aviv et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

Effect of heme oxygenase-1 on vascular function and disease

(2008) Jozef Dulak et al.   CURRENT OPINION IN LIPIDOLOGY

Bone and fat connection in aging bone

(2008) Gustavo Duque   CURRENT OPINION IN RHEUMATOLOGY

Linkage-dependent contribution of repeat peptides to self-aggregation of three- or four-repeat microtubule-binding domains in tau protein

(2008) Kayoko Okuyama et al.   FEBS Journal

IL-10 Overexpression Decreases Inflammatory Mediators and Promotes Regenerative Healing in an Adult Model of Scar Formation

(2008) William H. Peranteau et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

DNA damage and ageing: new-age ideas for an age-old problem

(2008) George A. Garinis et al.   NATURE CELL BIOLOGY

Effects of hydroxytyrosol-20 on carrageenan-induced acute inflammation and hyperalgesia in rats

(2008) Dezheng Gong et al.   PHYTOTHERAPY RESEARCH

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

(2008) Björn Schumacher et al.   PLoS Genetics

Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction

(2007) Liqi Tong et al.   NEUROBIOLOGY OF AGING