HepaRG microencapsulated spheroids in DMSO-free culture: novel culturing approaches for enhanced xenobiotic and biosynthetic metabolism

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

(2014) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models

(2014) Jonathan P. Celli et al.   Scientific Reports

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Impact of Alginate Composition: From Bead Mechanical Properties to Encapsulated HepG2/C3A Cell Activities for In Vivo Implantation

(2013) Stephanie H. Capone et al.   PLoS One

3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

(2013) Patrina Gunness et al.   TOXICOLOGICAL SCIENCES

Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells

(2013) Marc Le Vee et al.   TOXICOLOGY IN VITRO

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

(2012) Kazuo Takayama et al.   BIOMATERIALS

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

Organotypic liver culture models: Meeting current challenges in toxicity testing

(2012) Edward L. LeCluyse et al.   CRITICAL REVIEWS IN TOXICOLOGY

Liver Progenitor Cell Line HepaRG Differentiated in a Bioartificial Liver Effectively Supplies Liver Support to Rats with Acute Liver Failure

(2012) Geert A. A. Nibourg et al.   PLoS One

Three-Dimensional HepaRG Model As An Attractive Tool for Toxicity Testing

(2012) Sofia B. Leite et al.   TOXICOLOGICAL SCIENCES

Diverse effects of dimethyl sulfoxide (DMSO) on the differentiation potential of human embryonic stem cells

(2011) Rajarshi Pal et al.   ARCHIVES OF TOXICOLOGY

Hepatocyte polarization is essential for the productive entry of the hepatitis B virus

(2011) Andreas Schulze et al.   HEPATOLOGY

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

The HepaRG cell line is suitable for bioartificial liver application

(2011) Ruurdtje Hoekstra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities

(2011) Shih-Feng Lan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors

(2010) Rui M. Tostões et al.   BIOTECHNOLOGY AND BIOENGINEERING

Differentiation of bone marrow-derived mesenchymal stem cells into hepatocyte-like cells in an alginate scaffold

(2010) N. Lin et al.   CELL PROLIFERATION

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Gradients in the Liver's Extracellular Matrix Chemistry from Periportal to Pericentral Zones: Influence on Human Hepatic Progenitors

(2008) Randall McClelland et al.   TISSUE ENGINEERING PART A

Mature Human Hepatocytes from Ex Vivo Differentiation of Alginate-Encapsulated Hepatoblasts

(2008) Nancy Cheng et al.   TISSUE ENGINEERING PART A

Synthetic sandwich culture of 3D hepatocyte monolayer

(2007) Yanan Du et al.   BIOMATERIALS

Identification of metabolic fluxes in hepatic cells from transient13C-labeling experiments: Part I. Experimental observations

(2007) Ute Hofmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes

(2007) György Lengyel et al.   HEPATOLOGY RESEARCH