The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

(2016) Rowena L. Sison-Young et al.   ARCHIVES OF TOXICOLOGY

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

(2016) James A. Heslop et al.   ARCHIVES OF TOXICOLOGY

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

(2016) Volker M. Lauschke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

DNA Methylation of ADME Genes

(2016) P Fisel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Rare genetic variants in cellular transporters, metabolic enzymes and nuclear receptors can be important determinants of interindividual differences in drug response

(2016) Mikael Kozyra et al.   GENETICS IN MEDICINE

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

(2016) Volker M. Lauschke et al.   HEPATOLOGY

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression

(2016) Maxim Ivanov et al.   NUCLEIC ACIDS RESEARCH

Requirements for comprehensive pharmacogenetic genotyping platforms

(2016) Volker M Lauschke et al.   PHARMACOGENOMICS

Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI)

(2016) Muzeeb Syed et al.   TOXICOLOGY IN VITRO

Precision Medicine and Rare Genetic Variants

(2016) Volker M. Lauschke et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

(2016) Matthew D. Davidson et al.   Scientific Reports

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Pharmacogenetics of Cancer Drugs

(2015) Daniel L. Hertz et al.   Annual Review of Medicine

Predicting Toxicities of Reactive Metabolite–Positive Drug Candidates

(2015) Amit S. Kalgutkar et al.   Annual Review of Pharmacology and Toxicology

Heritability of metoprolol and torsemide pharmacokinetics

(2015) J Matthaei et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Efficacy and safety of fasiglifam (TAK-875), a G protein-coupled receptor 40 agonist, in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise: a randomized, double-blind, placebo-controlled, phase III trial

(2015) K. Kaku et al.   DIABETES OBESITY & METABOLISM

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury

(2015) Seung-Hyun Kim et al.   HEPATOLOGY

P0972 : Expressions of bile acid transporters are inversely correlated with NAFLD activity score in the liver of patients with non-alcoholic fatty liver disease

(2015) K. Okushin et al.   JOURNAL OF HEPATOLOGY

Pharmacogenomics in the clinic

(2015) Mary V. Relling et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation

(2015) Antonia A. Dominguez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity

(2015) Elena M. Cornejo Castro et al.   Pharmacogenetics and Genomics

Genetic variation in the human cytochrome P450 supergene family

(2015) Kohei Fujikura et al.   Pharmacogenetics and Genomics

Pharmacogenomic information in drug labels: European Medicines Agency perspective

(2015) F Ehmann et al.   PHARMACOGENOMICS JOURNAL

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran

(2015) Etienne P. A. Neve et al.   PLoS One

Competency of different cell models to predict human hepatotoxic drugs

(2014) M José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury

(2014) Kang Kwang Lee et al.   HEPATOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

(2014) Jacqueline I. Goldstein et al.   Nature Communications

Pharmacogenomics: Current State-of-the-Art

(2014) Daniel Carr et al.   Genes

HLA-B*5701 and flucloxacillin associated drug-induced liver disease

(2013) Elizabeth J. Phillips et al.   AIDS

Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population

(2013) Daniel F. Carr et al.   CLINICAL INFECTIOUS DISEASES

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

(2013) Cliff Rowe et al.   HEPATOLOGY

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset

(2013) A. S. Gordon et al.   HUMAN MOLECULAR GENETICS

Bringing genome-wide association findings into clinical use

(2013) Teri A. Manolio   NATURE REVIEWS GENETICS

HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity

(2013) Camilla Stephens et al.   PLoS One

Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function

(2013) Maxim Ivanov et al.   GENOME BIOLOGY

Relationship Between theHLA-B*1502Allele and Carbamazepine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

(2013) Wimonchat Tangamornsuksan et al.   JAMA Dermatology

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

DNA methylation dynamics in the hepatic CYP3A4 gene promoter

(2012) Marina Kacevska et al.   BIOCHIMIE

Identification of Protein Targets of Reactive Metabolites of Tienilic Acid in Human Hepatocytes

(2012) Yakov M. Koen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility

(2012) A Alfirevic et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

(2012) Suvi T. M. Orr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

(2012) Patricia T. Illing et al.   NATURE

Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects

(2012) S C Sim et al.   PHARMACOGENOMICS JOURNAL

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer

(2011) Jorja D Warren et al.   BMC Medicine

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing

(2011) J A Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

(2011) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Central role of mitochondria in drug-induced liver injury

(2011) Dominique Pessayre et al.   DRUG METABOLISM REVIEWS

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events

(2011) Michael V. Holmes et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genomics and Drug Response

(2011) Liewei Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

(2011) Mark McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity

(2011) Ursula Amstutz et al.   PHARMACOGENOMICS

Involvement of natural killer T cells in halothane-induced liver injury in mice

(2010) Linling Cheng et al.   BIOCHEMICAL PHARMACOLOGY

Do selected drugs increase the risk of lupus? A matched case-control study

(2010) W. Marieke Schoonen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Enhanced Susceptibility of HLA-mediated Ticlopidine-induced Idiosyncratic Hepatotoxicity by CYP2B6 Polymorphism in Japanese

(2010) Noritaka Ariyoshi et al.   Drug Metabolism and Pharmacokinetics

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells

(2010) Ana Blas-García et al.   HEPATOLOGY

Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population

(2010) Takeshi Ozeki et al.   HUMAN MOLECULAR GENETICS

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Hepatic Gene Expression of Caucasian and African-American Patients with Obesity-Related Non-Alcoholic Fatty Liver Disease

(2010) Maria Stepanova et al.   OBESITY SURGERY

Role of Alcohol Metabolism in Non-Alcoholic Steatohepatitis

(2010) Susan S. Baker et al.   PLoS One

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES

Genotyping Technologies for Genetic Research

(2009) Jiannis Ragoussis   Annual Review of Genomics and Human Genetics

Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis

(2009) Cátia C.P. Aires et al.   BIOCHEMICAL PHARMACOLOGY

A Strategy for the Risk Assessment of Human Genotoxic Metabolites

(2009) Krista L. Dobo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Recent insights into the genetic basis of systemic lupus erythematosus

(2009) K L Moser et al.   GENES AND IMMUNITY

Metabolism and Disposition of the Thienopyridine Antiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans

(2009) Nagy A. Farid et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Multicenter Evaluation of an Investigational Prostate Cancer Methylation Assay

(2009) Jonathan Baden et al.   JOURNAL OF UROLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population

(2009) Wichittra Tassaneeyakul et al.   Pharmacogenetics and Genomics

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

(2009) et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes

(2009) Lyudmila I. Rachek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

(2009) Lisa F. Barcellos et al.   PLoS Genetics

The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV

(2008) Bruce R Schackman et al.   AIDS

Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population

(2008) Chaichon Locharernkul et al.   EPILEPSIA

The CYP2C19 ultra-rapid metabolizer genotype influences the pharmacokinetics of voriconazole in healthy male volunteers

(2008) Guo Wang et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States

(2008) Naga Chalasani et al.   GASTROENTEROLOGY

Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice

(2008) Terry G. J. Derks et al.   HEPATOLOGY

Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

(2008) Diana Chessman et al.   IMMUNITY

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A European study of HLA-B in Stevens???Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs

(2008) Christine Lonjou et al.   Pharmacogenetics and Genomics

HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis

(2008) Nahoko Kaniwa et al.   PHARMACOGENOMICS

Pharmacogenomic Biomarker Information in Drug Labels Approved by the United States Food and Drug Administration: Prevalence of Related Drug Use

(2008) Felix W Frueh et al.   PHARMACOTHERAPY

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES