Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

Fluid shear stress modulation of hepatocyte-like cell function

(2016) Hassan Rashidi et al.   ARCHIVES OF TOXICOLOGY

Liver metastases: Microenvironments and ex-vivo models

(2016) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin

(2016) Junyan Tao et al.   HEPATOLOGY

Solubilized liver extracellular matrix maintains primary rat hepatocyte phenotypein-vitro

(2016) Abigail E. Loneker et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A microfluidically perfused three dimensional human liver model

(2015) Knut Rennert et al.   BIOMATERIALS

Fluorescent protein biosensors applied to microphysiological systems

(2015) Nina Senutovitch et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

(2015) Satdarshan Pal Monga   GASTROENTEROLOGY

Hepatitis C viral proteins perturb metabolic liver zonation

(2015) Marie Moreau et al.   JOURNAL OF HEPATOLOGY

A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia

(2015) Michael Erickstad et al.   LAB ON A CHIP

An in vitro hepatic zonation model with a continuous oxygen gradient in a microdevice

(2014) Asako Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxygen control with microfluidics

(2014) Martin D. Brennan et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

(2014) Rolf Gebhardt   WORLD JOURNAL OF GASTROENTEROLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Variation in diffusion of gases through PDMS due to plasma surface treatment and storage conditions

(2013) Dmitry A. Markov et al.   BIOMEDICAL MICRODEVICES

Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix

(2013) Lorenna D. Buck et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic oxygen imaging using integrated optical sensor layers and a color camera

(2013) Birgit Ungerböck et al.   LAB ON A CHIP

Optimal periodic perfusion strategy for robust long-term microfluidic cell culture

(2013) Stefano Giulitti et al.   LAB ON A CHIP

Spatially monitoring oxygen level in 3D microfabricated cell culture systems using optical oxygen sensing beads

(2013) Lin Wang et al.   LAB ON A CHIP

A microfluidic cell culture array with various oxygen tensions

(2013) Chien-Chung Peng et al.   LAB ON A CHIP

Oxygen levels in thermoplastic microfluidic devices during cell culture

(2013) Christopher J. Ochs et al.   LAB ON A CHIP

Simultaneous measurement of dissolved oxygen concentration and velocity field in microfluidics using oxygen-sensitive particles

(2013) Hyun Dong Kim et al.   Microfluidics and Nanofluidics

Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis

(2013) Julia Wattacheril et al.   PLoS One

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

(2013) Radina Kostadinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The contribution of oxidative stress to drug-induced organ toxicity and its detectionin vitroandin vivo

(2012) Claudia V Pereira et al.   Expert Opinion on Drug Metabolism & Toxicology

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

(2011) Yosuke Nakao et al.   Biomicrofluidics

The rate of oxygen utilization by cells

(2011) Brett A. Wagner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Generation of oxygen gradients in microfluidic devices for cell culture using spatially confined chemical reactions

(2011) Yung-Ann Chen et al.   LAB ON A CHIP

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

The Design of In Vitro Liver Sinusoid Mimics Using Chitosan–Hyaluronic Acid Polyelectrolyte Multilayers

(2010) Yeonhee Kim et al.   TISSUE ENGINEERING PART A

Fluorescent microparticles for sensing cell microenvironment oxygen levels within 3D scaffolds

(2009) Miguel A. Acosta et al.   BIOMATERIALS

Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro

(2009) Sandra March et al.   HEPATOLOGY

Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures

(2009) Mark Polinkovsky et al.   LAB ON A CHIP

Generation of oxygen gradients with arbitrary shapes in a microfluidic device

(2009) Micha Adler et al.   LAB ON A CHIP

Real time in vitro measurement of oxygen uptake rates for HEPG2 liver cells encapsulated in alginate matrices

(2009) Anuja Mishra et al.   Microfluidics and Nanofluidics

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance

(2009) S. Kidambi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low O2 metabolism of HepG2 cells cultured at high density in a 3D microstructured scaffold

(2008) Christophe Provin et al.   BIOMEDICAL MICRODEVICES

In vitro analysis of a hepatic device with intrinsic microvascular-based channels

(2008) Amedeo Carraro et al.   BIOMEDICAL MICRODEVICES

Monitoring pH and dissolved oxygen in mammalian cell culture using optical sensors

(2008) Mariam Naciri et al.   CYTOTECHNOLOGY

A microwell array device capable of measuring single-cell oxygen consumption rates

(2008) Timothy W. Molter et al.   SENSORS AND ACTUATORS B-CHEMICAL

Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates

(2007) Jaesung Park et al.   BIOTECHNOLOGY AND BIOENGINEERING