A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

(2016) Arvind Pradip et al.   Stem Cells International

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

(2015) Rowena L. C. Sison-Young et al.   TOXICOLOGICAL SCIENCES

Toward predictive models for drug-induced liver injury in humans: are we there yet?

(2014) Minjun Chen et al.   Biomarkers in Medicine

Relative bioavailability of a newly developed pediatric formulation of bosentan vs. the adult formulation

(2013) Marcelo M. Gutierrez et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans

(2013) Frida Gustafsson et al.   TOXICOLOGICAL SCIENCES

Accurate Prediction of Drug-Induced Liver Injury Using Stem Cell-Derived Populations

(2013) Dagmara Szkolnicka et al.   Stem Cells Translational Medicine

In vivo Bioequivalence of Oral Antidiabetic Agents: Pioglitazone Tablets

(2012) Hong Wong et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes

(2012) Cornelia M. Smith et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Generation of proliferating human hepatocytes using upcyte®technology: characterisation and applications in induction and cytotoxicity assays

(2012) Alexandra Burkard et al.   XENOBIOTICA

Mechanisms of drug-induced liver injury: from bedside to bench

(2011) Shannan Tujios et al.   Nature Reviews Gastroenterology & Hepatology

The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells

(2010) Anja Zahno et al.   BIOCHEMICAL PHARMACOLOGY

The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin

(2009) M V Tzvetkov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Epidemiology of Idiosyncratic Drug-Induced Liver Injury

(2009) Lauren Bell et al.   SEMINARS IN LIVER DISEASE

Pro-inflammatory response and adverse drug reactions: Mechanisms of action of ximelagatran on chemokine and cytokine activation in a monocyte in vitro model

(2008) Ylva Edling et al.   TOXICOLOGY IN VITRO

Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions

(2008) Carine B. Lambert et al.   TOXICOLOGY IN VITRO