Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

(2018) Lorna Ewart et al.   Annual Review of Pharmacology and Toxicology

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

(2018) Chris S. Pridgeon et al.   ARCHIVES OF TOXICOLOGY

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

(2018) Sabine U Vorrink et al.   TOXICOLOGICAL SCIENCES

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

(2018) Catherine C Bell et al.   TOXICOLOGICAL SCIENCES

A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX

(2018) Xiang Li et al.   LAB ON A CHIP

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

(2017) Felipe T Lee-Montiel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

(2017) Sabine U. Vorrink et al.   FASEB JOURNAL

Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?

(2017) William M. Lee   JOURNAL OF HEPATOLOGY

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

(2016) Sanja Dragovic et al.   ARCHIVES OF TOXICOLOGY

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

(2016) Rowena L. Sison-Young et al.   ARCHIVES OF TOXICOLOGY

Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury

(2016) ADB Vliegenthart et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Microfabricated Devices for Studying the Metabolism and Cytotoxicity of Drug Candidates

(2016) Nathan A. Whitman et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The pathogenesis of drug-induced liver injury

(2016) Sun-Jae Lee et al.   Expert Review of Gastroenterology & Hepatology

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro

(2015) Mi Jang et al.   Biomicrofluidics

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

PharmGKB summary

(2015) Liudmila L. Mazaleuskaya et al.   Pharmacogenetics and Genomics

Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

(2014) Anna-Karin M. Sjogren et al.   ARCHIVES OF TOXICOLOGY

In vitro platforms for evaluating liver toxicity

(2014) Shyam Sundhar Bale et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

(2014) Aurelie Vivares et al.   XENOBIOTICA

The Generation, Detection, and Effects of Reactive Drug Metabolites

(2012) Andrew V. Stachulski et al.   MEDICINAL RESEARCH REVIEWS

Novel in vitro and mathematical models for the prediction of chemical toxicity

(2012) Dominic P. Williams et al.   Toxicology Research

Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes

(2011) Bruna Vinci et al.   Biotechnology Journal

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Assessment of cryopreserved human hepatocytes as a model system to investigate sulfation and glucuronidation and to evaluate inhibitors of drug conjugation

(2009) Z. Riches et al.   XENOBIOTICA

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

(2009) J. E. Laine et al.   XENOBIOTICA