Three-Dimensional HepaRG Model As An Attractive Tool for Toxicity Testing

Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

(2012) François Bouzom et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

(2012) Yuan Chen et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

Characterization of human cytochrome P450 induction by pesticides

(2012) Khaled Abass et al.   TOXICOLOGY

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids

(2011) Julia Schütte et al.   BIOMEDICAL MICRODEVICES

Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes

(2011) T. Nakanishi et al.   DRUG METABOLISM AND DISPOSITION

Hepatocyte polarization is essential for the productive entry of the hepatitis B virus

(2011) Andreas Schulze et al.   HEPATOLOGY

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

The HepaRG cell line is suitable for bioartificial liver application

(2011) Ruurdtje Hoekstra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies

(2011) Katrin Zeilinger et al.   TISSUE ENGINEERING PART C-METHODS

Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye

(2011) K. Pernelle et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: Improved in vitro models for toxicological applications

(2011) Sofia B. Leite et al.   TOXICOLOGY IN VITRO

Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors

(2010) Rui M. Tostões et al.   BIOTECHNOLOGY AND BIOENGINEERING

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers

(2010) Bridget C. Fox et al.   TOXICOLOGY IN VITRO

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An Approach for Formation of Vascularized Liver Tissue by Endothelial Cell–Covered Hepatocyte Spheroid Integration

(2009) Masakazu Inamori et al.   TISSUE ENGINEERING PART A

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

(2009) Miia Turpeinen et al.   TOXICOLOGY IN VITRO

Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions

(2009) Catherine Abadie-Viollon et al.   TOXICOLOGY IN VITRO

Inter-laboratory evaluation of the response of primary human hepatocyte cultures to model CYP inducers – A European Centre for Validation of Alternative Methods (ECVAM) – Funded pre-validation study

(2009) Lysiane Richert et al.   TOXICOLOGY IN VITRO

Local Kinetics and Dynamics of Xenobiotics

(2008) Olavi Pelkonen et al.   CRITICAL REVIEWS IN TOXICOLOGY

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

Towards an Extended Functional Hepatocyte In Vitro Culture

(2008) Joana P. Miranda et al.   TISSUE ENGINEERING PART C-METHODS

Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells

(2008) Carine B. Lambert et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration

(2007) I A Gibb et al.   ARCHIVES OF DISEASE IN CHILDHOOD