Toxicogenomics directory of chemically exposed human hepatocytes

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

(2014) Nina V. Balmer et al.   ARCHIVES OF TOXICOLOGY

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

(2014) Gisela Campos et al.   ARCHIVES OF TOXICOLOGY

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

(2014) Tanja Waldmann et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

(2014) Freimut Schliess et al.   HEPATOLOGY

Lineage-Specific Regulation of Epigenetic Modifier Genes in Human Liver and Brain

(2014) Matthias K. Weng et al.   PLoS One

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Pathways for Ligand Activated Nuclear Receptors to Unravel the Genomic Responses Induced by Hepatotoxicants

(2013) R.R.R. Fijten et al.   CURRENT DRUG METABOLISM

Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by Liver X receptor α through a sterol regulatory element-binding protein 1c-dependent mechanism in mice

(2013) Jing Wu et al.   HEPATOLOGY

LTMap: a web server for assessing the potential liver toxicity by genome-wide transcriptional expression data

(2013) Li Xing et al.   JOURNAL OF APPLIED TOXICOLOGY

Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods

(2013) Leif Väremo et al.   NUCLEIC ACIDS RESEARCH

Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

(2013) J D Zhang et al.   PHARMACOGENOMICS JOURNAL

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

(2012) Markus Schug et al.   ARCHIVES OF TOXICOLOGY

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

(2012) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

In Vitro - In Vivo Correlation of Gene Expression Alterations Induced by Liver Carcinogens

(2012) T. Heise et al.   CURRENT MEDICINAL CHEMISTRY

Expression and Regulation of Human Fetal-Specific CYP3A7 in Mice

(2012) Xiao-Yan Pang et al.   ENDOCRINOLOGY

Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

(2011) A. D. Lake et al.   DRUG METABOLISM AND DISPOSITION

Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma

(2011) Edmund Kwok-Kwan Tung et al.   LIVER INTERNATIONAL

Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database

(2011) Takeki Uehara et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes

(2010) Sebastian Zellmer et al.   HEPATOLOGY

Expander: from expression microarrays to networks and functions

(2010) Igor Ulitsky et al.   Nature Protocols

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytes

(2009) Patricio Godoy et al.   BIOLOGICAL CHEMISTRY

Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by 31P NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholines

(2009) Alexander Bauer et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β-induced apoptosis

(2009) Patricio Godoy et al.   HEPATOLOGY

RGC-32 Mediates Transforming Growth Factor-β-induced Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Cells

(2009) Wen-Yan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects

(2009) Yukiko Kimura et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy

(2009) Mitsuhiro Hirode et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Scoring multiple toxicological endpoints using a toxicogenomic database

(2009) Naoki Kiyosawa et al.   TOXICOLOGY LETTERS

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

(2007) Heidrun Ellinger-Ziegelbauer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS