A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Molecular Mechanisms of Hepatocellular Apoptosis Induced by Trovafloxacin-Tumor Necrosis Factor-alpha Interaction

(2013) Kevin M. Beggs et al.   TOXICOLOGICAL SCIENCES

3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

(2013) Patrina Gunness et al.   TOXICOLOGICAL SCIENCES

3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies

(2013) Daniel Mueller et al.   TOXICOLOGY IN VITRO

Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice

(2012) E. van de Steeg et al.   CLINICAL CANCER RESEARCH

Organotypic liver culture models: Meeting current challenges in toxicity testing

(2012) Edward L. LeCluyse et al.   CRITICAL REVIEWS IN TOXICOLOGY

Microtissue size and hypoxia in HTS with 3D cultures

(2012) Amish Asthana et al.   DRUG DISCOVERY TODAY

Enhanced bile canaliculi formation enabling direct recovery of biliary metabolites of hepatocytes in 3D collagen gel microcavities

(2012) Hitoshi Matsui et al.   LAB ON A CHIP

Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cells and Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression

(2012) Gang Chen et al.   PLoS One

Peptide Nanofiber Hydrogel Induces Formation of Bile Canaliculi Structures in Three-Dimensional Hepatic Cell Culture

(2012) Melina M. Malinen et al.   TISSUE ENGINEERING PART A

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

(2012) Salman R. Khetani et al.   TOXICOLOGICAL SCIENCES

Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line

(2012) Stephen J. Fey et al.   TOXICOLOGICAL SCIENCES

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

(2011) Lisa Fredriksson et al.   HEPATOLOGY

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Newin VitroTools to Study Human Constitutive Androstane Receptor (CAR) Biology: Discovery and Comparison of Human CAR Inverse Agonists

(2011) Jenni Küblbeck et al.   MOLECULAR PHARMACEUTICS

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

(2010) L. Guo et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

(2010) Kazuaki Nakamura et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

QSG-7701 human hepatocytes form polarized acini in three-dimensional culture

(2010) Fang Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells

(2010) Yuichiro Kanno et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

(2009) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Toxicity Testing in the 21st Century: A View from the Pharmaceutical Industry

(2009) James S. MacDonald et al.   TOXICOLOGICAL SCIENCES

Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors

(2008) K. Abe et al.   DRUG METABOLISM AND DISPOSITION

Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review

(2008) M. F. B. Silva et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Pregnane X Receptor Protects HepG2 Cells from BaP-Induced DNA Damage

(2008) Christine Naspinski et al.   TOXICOLOGICAL SCIENCES

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES