3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

Real-time in situ viability assessment in a 3D bioreactor with liver cells using resazurin assay

(2012) Daniel Mueller et al.   CYTOTECHNOLOGY

Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties

(2012) Sudipta Saha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Three-Dimensional HepaRG Model As An Attractive Tool for Toxicity Testing

(2012) Sofia B. Leite et al.   TOXICOLOGICAL SCIENCES

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

(2012) Sébastien Anthérieu et al.   TOXICOLOGY IN VITRO

Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity

(2012) Jae-Ah Kim et al.   TOXICOLOGY LETTERS

Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes

(2011) Eiichiro Ogimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues

(2011) Maren Drewitz et al.   Biotechnology Journal

Toxic Metabolite Formation from Troglitazone (TGZ): New Insights from a DFT Study

(2011) Vaibhav A. Dixit et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Enhancement of drug efflux activity via MDR1 protein by spheroid culture of human hepatic cancer cells

(2011) Ayumi Oshikata et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor

(2011) Daniel Mueller et al.   Journal of Tissue Engineering and Regenerative Medicine

Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies

(2011) Katrin Zeilinger et al.   TISSUE ENGINEERING PART C-METHODS

Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes

(2011) Alexander Strigun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Extending Hepatocyte Functionality for Drug-Testing Applications Using High-Viscosity Alginate–Encapsulated Three-Dimensional Cultures in Bioreactors

(2010) Joana P. Miranda et al.   TISSUE ENGINEERING PART C-METHODS

Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen

(2010) Laetitia Knockaert et al.   TOXICOLOGY IN VITRO

Comparative Analysis of Gene Expression in Rat Liver Tissue and Monolayer- and Spheroid-Cultured Hepatocytes

(2009) Yusuke Sakai et al.   CELLS TISSUES ORGANS

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β-induced apoptosis

(2009) Patricio Godoy et al.   HEPATOLOGY

Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2

(2009) Jens Niklas et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model

(2009) Ylva Edling et al.   TOXICOLOGY IN VITRO

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies

(2008) R. Josse et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism

(2008) Gregor Tuschl et al.   Expert Opinion on Drug Metabolism & Toxicology

Towards an Extended Functional Hepatocyte In Vitro Culture

(2008) Joana P. Miranda et al.   TISSUE ENGINEERING PART C-METHODS

Long-term viability and proliferation of alginate-encapsulated 3-D HepG2 aggregates formed in an ultrasound trap

(2008) D. Bazou et al.   TOXICOLOGY IN VITRO

Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration

(2007) I A Gibb et al.   ARCHIVES OF DISEASE IN CHILDHOOD