Lysosomes as a therapeutic target

Presenilins and γ-Secretase in Membrane Proteostasis

(2019) Naoto Oikawa et al.   Cells

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

(2019) Israel Hernandez et al.   Science Translational Medicine

Berberine as a potential autophagy modulator

(2019) Reza Mohammadinejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Does intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer’s disease?

(2019) I. Lauritzen et al.   Current Alzheimer Research

Pharmacological Autophagy Regulators as Therapeutic Agents for Inflammatory Bowel Diseases

(2019) Sruthi Vijaya Retnakumar et al.   TRENDS IN MOLECULAR MEDICINE

Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability

(2019) Oscar Vivas et al.   Cell Reports

Diagnostic challenge for the rare lysosomal storage disease: Late infantile GM1 gangliosidosis

(2018) Jin Sook Lee et al.   BRAIN & DEVELOPMENT

Emerging roles of microglial cathepsins in neurodegenerative disease

(2018) Jessica R. Lowry et al.   BRAIN RESEARCH BULLETIN

TRPML1: The Ca (2+) retaker of the lysosome

(2018) Simone Di Paola et al.   CELL CALCIUM

The hidden potential of lysosomal ion channels: A new era of oncogenes

(2018) Andra M Sterea et al.   CELL CALCIUM

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

A cross-sectional quantitative analysis of the natural history of free sialic acid storage disease—an ultra-orphan multisystemic lysosomal storage disorder

(2018) Matthias Zielonka et al.   GENETICS IN MEDICINE

Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide

(2018) Baihui Li et al.   JOURNAL OF AUTOIMMUNITY

An autophagy-targeting peptide to treat chronic inflammatory demyelinating polyneuropathies

(2018) Susana Brun et al.   JOURNAL OF AUTOIMMUNITY

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

(2018) Christopher H. Choy et al.   JOURNAL OF CELL SCIENCE

mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a

(2018) Andrew J. Monteith et al.   JOURNAL OF IMMUNOLOGY

Functional up-regulation of the M-current by retigabine contrasts hyperexcitability and excitotoxicity on rat hypoglossal motoneurons

(2018) Filippo Ghezzi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

The curious case of vacuolar ATPase: regulation of signaling pathways

(2018) Sahithi Pamarthy et al.   Molecular Cancer

Odiparcil is a promising substrate reduction therapy in MPS VI murine model

(2018) Eugeni V. Entchev et al.   MOLECULAR GENETICS AND METABOLISM

Overexpression of TFEB Drives a Pleiotropic Neurotrophic Effect and Prevents Parkinson’s Disease-Related Neurodegeneration

(2018) Albert Torra et al.   MOLECULAR THERAPY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

(2018) Constanza J. Cortes et al.   NEUROBIOLOGY OF DISEASE

Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones

(2018) David M. Pereira et al.   Chemical Science

Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients

(2018) Maria C. Edman et al.   Scientific Reports

Lupus Regulator Peptide P140 Represses B Cell Differentiation by Reducing HLA Class II Molecule Overexpression

(2018) Maud Wilhelm et al.   Arthritis & Rheumatology

Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer’s Disease

(2018) Ximeng Yang et al.   Frontiers in Pharmacology

Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives

(2018) Marta Vomero et al.   Frontiers in Immunology

Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option

(2018) Srinivasa Reddy Bonam et al.   JOURNAL OF AUTOIMMUNITY

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic approaches to Huntington disease: from the bench to the clinic

(2018) Nicholas S. Caron et al.   NATURE REVIEWS DRUG DISCOVERY

Miglustat in Niemann-Pick disease type C patients: a review

(2018) Mercè Pineda et al.   Orphanet Journal of Rare Diseases

Lysosomal membrane permeabilization and cell death

(2018) Fengjuan Wang et al.   TRAFFIC

Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons

(2018) J. Magalhaes et al.   Scientific Reports

The Therapeutic and Pathogenic Role of Autophagy in Autoimmune Diseases

(2018) Heng Yin et al.   Frontiers in Immunology

The Mitochondrion-lysosome Axis in Adaptive and Innate Immunity: Effect of Lupus Regulator Peptide P140 on Mitochondria Autophagy and NETosis

(2018) Mykolas Bendorius et al.   Frontiers in Immunology

Early higher dosage of alglucosidase alpha in classic Pompe disease

(2018) Marco Spada et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis

(2018) Alberto di Ronza et al.   NATURE CELL BIOLOGY

Blocking nuclear export of HSPA8 after heat shock stress severely alters cell survival

(2018) Fengjuan Wang et al.   Scientific Reports

The Roles of Endo-Lysosomes in Unconventional Protein Secretion

(2018) Juhyung Lee et al.   Cells

Humanin is an endogenous activator of chaperone-mediated autophagy

(2017) Zhenwei Gong et al.   JOURNAL OF CELL BIOLOGY

Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia

(2017) Deepti Lall et al.   JOURNAL OF CLINICAL INVESTIGATION

Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations inFaslprMice

(2017) Yi Zhou et al.   JOURNAL OF IMMUNOLOGY

Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

(2017) Lauren S. Whyte et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy and mitophagy elements are increased in body fluids of multiple sclerosis-affected individuals

(2017) Simone Patergnani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway

(2017) Katarina Trajkovic et al.   JOURNAL OF NEUROSCIENCE

A multicenter, open-label, phase III study of Abcertin in Gaucher disease

(2017) Beom Hee Lee et al.   MEDICINE

How close are we to therapies for Sanfilippo disease?

(2017) Lidia Gaffke et al.   METABOLIC BRAIN DISEASE

Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin

(2017) Ping Shao et al.   Molecular Medicine Reports

The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture

(2017) Changkeun Lee et al.   NATURE

Emptying the stores: lysosomal diseases and therapeutic strategies

(2017) Frances M. Platt   NATURE REVIEWS DRUG DISCOVERY

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease

(2017) Elma Aflaki et al.   NEURON

Lucerastat, an iminosugar with potential as substrate reduction therapy for glycolipid storage disorders: safety, tolerability, and pharmacokinetics in healthy subjects

(2017) N. Guérard et al.   Orphanet Journal of Rare Diseases

Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren’s Syndrome

(2017) Zhen Meng et al.   PLoS One

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

(2017) Sarah Jinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders

(2017) Nicoletta Plotegher et al.   TRENDS IN MOLECULAR MEDICINE

Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

(2017) Anand Patwardhan et al.   Nature Communications

Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury

(2017) Maia Tato et al.   Scientific Reports

Molecular Mechanisms Involved in Schwann Cell Plasticity

(2017) Angélique Boerboom et al.   Frontiers in Molecular Neuroscience

Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand

(2017) Nandini Ramesh et al.   Frontiers in Molecular Neuroscience

Pharmaceutical Chaperones and Proteostasis Regulators in the Therapy of Lysosomal Storage Disorders: Current Perspective and Future Promises

(2017) Fedah E. Mohamed et al.   Frontiers in Pharmacology

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

(2017) Matthew Redmann et al.   Redox Biology

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Assessing Autophagy in Sciatic Nerves of a Rat Model that Develops Inflammatory Autoimmune Peripheral Neuropathies

(2017) Susana Brun et al.   Cells

Assessing Autophagy in Mouse Models and Patients with Systemic Autoimmune Diseases

(2017) Fengjuan Wang et al.   Cells

Elevation of autophagy markers in Sjögren syndrome dry eye

(2017) Yong-Soo Byun et al.   Scientific Reports

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Lysosomal cathepsins and their regulation in aging and neurodegeneration

(2016) Veronika Stoka et al.   AGEING RESEARCH REVIEWS

Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome

(2016) Zhen Meng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Protein aggregation and neurodegenerative diseases: From theory to therapy

(2016) Vijay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

(2016) Kara G. Lassen et al.   IMMUNITY

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study

(2016) Derralynn A Hughes et al.   JOURNAL OF MEDICAL GENETICS

A New Glucocerebrosidase Chaperone Reduces  -Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

(2016) E. Aflaki et al.   JOURNAL OF NEUROSCIENCE

Treatment for Krabbe's disease: Finding the combination

(2016) Christina R. Mikulka et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders

(2016) Chiara Vidoni et al.   MEDICINAL RESEARCH REVIEWS

CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease

(2016) John Marshall et al.   MOLECULAR THERAPY

Prevalence of Pompe disease in 3,076 patients with hyperCKemia and limb-girdle muscular weakness

(2016) Zoltan Lukacs et al.   NEUROLOGY

Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients

(2016) Bouwien E. Smid et al.   Orphanet Journal of Rare Diseases

Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus

(2016) Andrew J. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidroxicloroquina en el tratamiento de las enfermedades autoinmunes sistémicas

(2016) Álvaro Danza et al.   REVISTA MEDICA DE CHILE

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease

(2016) Christopher Fox et al.   Scientific Reports

Rab1-dependent ER–Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS

(2015) Kai Y. Soo et al.   ACTA NEUROPATHOLOGICA

Central effects of humanin on hepatic triglyceride secretion

(2015) Zhenwei Gong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lysosomal Storage Diseases: From Pathophysiology to Therapy

(2015) Giancarlo Parenti et al.   Annual Review of Medicine

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide

(2015) Christophe Macri et al.   Autophagy

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

(2015) Sonja Aits et al.   Autophagy

Regulation of TRPML1 function

(2015) Helen Waller-Evans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis

(2015) Le T. Duong et al.   CALCIFIED TISSUE INTERNATIONAL

TMEM175 Is an Organelle K + Channel Regulating Lysosomal Function

(2015) Chunlei Cang et al.   CELL

Nanomaterials, Autophagy, and Lupus Disease

(2015) Alberto Bianco et al.   ChemMedChem

Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease

(2015) Christine Erie et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role

(2015) Liang Hao et al.   FEBS LETTERS

Pharmacologic agents targeting autophagy

(2015) Helin Vakifahmetoglu-Norberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in autoimmune disease

(2015) Zhen Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Discovery of a Small-Molecule Probe for V-ATPase Function

(2015) Leslie N. Aldrich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Autophagy dysregulation in amyotrophic lateral sclerosis

(2015) W. Le et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Resetting the autoreactive immune system with a therapeutic peptide in lupus

(2015) N Schall et al.   LUPUS

Methods to study chaperone-mediated autophagy

(2015) Bindi Patel et al.   METHODS

Delayed diagnosis of late-onset Pompe disease in patients with myopathies of unknown origin and/or hyperCKemia

(2015) Jordi Pérez-López et al.   MOLECULAR GENETICS AND METABOLISM

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Exome sequencing uncovers hidden pathways in familial and sporadic ALS

(2015) Conceição Bettencourt et al.   NATURE NEUROSCIENCE

Natural disease history and characterisation of SUMF1 molecular defects in ten unrelated patients with multiple sulfatase deficiency

(2015) Frédérique Sabourdy et al.   Orphanet Journal of Rare Diseases

Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies

(2015) Tomas Weitoft et al.   RHEUMATOLOGY

Enzyme replacement therapy: lessons learned and emerging questions

(2015) Agnieszka Jurecka et al.   Expert Opinion on Orphan Drugs

Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

(2015) Marton Siklos et al.   Acta Pharmaceutica Sinica B

Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry

(2014) Ling Wu et al.   ACS Nano

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

(2014) Alexander J Clarke et al.   ANNALS OF THE RHEUMATIC DISEASES

Mucolipidosis type IV: The importance of functional lysosomes for efficient autophagy

(2014) Silvia Vergarajauregui et al.   Autophagy

Role for nanomaterial-autophagy interaction in neurodegenerative disease

(2014) Stephan T. Stern et al.   Autophagy

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

(2014) Melissa Nassif et al.   Autophagy

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

(2014) Karen E. Murphy et al.   BRAIN

Pharmacological regulators of autophagy and their link with modulators of lupus disease

(2014) Frédéric Gros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1

(2014) Xinghua Feng et al.   CELL CALCIUM

Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis

(2014) José A. Martina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exploiting Intrinsic Nanoparticle Toxicity: The Pros and Cons of Nanoparticle-Induced Autophagy in Biomedical Research

(2014) Karen Peynshaert et al.   CHEMICAL REVIEWS

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Evaluation of acridine orange, LysoTracker Red, and quinacrine as fluorescent probes for long-term tracking of acidic vesicles

(2014) Agnieszka Pierzyńska-Mach et al.   CYTOMETRY PART A

The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy

(2014) Constanza J. Cortes et al.   DRUG DISCOVERY TODAY

VER-155008, a small molecule inhibitor of HSP70 with potent anti-cancer activity on lung cancer cell lines

(2014) Wei Wen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia

(2014) N. Yuan et al.   HAEMATOLOGICA

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

(2014) Manal A. Farg et al.   HUMAN MOLECULAR GENETICS

Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis

(2014) Haijian Wu et al.   International Journal of Biological Sciences

The Roles of Lysosomes in Inflammation and Autoimmune Diseases

(2014) Wei Ge et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation

(2014) Marta Moskot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

The importance of implementing proper selection of excipients in lupus clinical trials

(2014) S Muller et al.   LUPUS

Pharmacological chaperones increase residual β-galactocerebrosidase activity in fibroblasts from Krabbe patients

(2014) Anna Sara Berardi et al.   MOLECULAR GENETICS AND METABOLISM

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

(2014) Sami J Barmada et al.   Nature Chemical Biology

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers

(2014) Hélène Jeltsch-David et al.   Nature Reviews Neurology

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis

(2014) Junchao Duan et al.   Particle and Fibre Toxicology

Lysosome Transport as a Function of Lysosome Diameter

(2014) Debjyoti Bandyopadhyay et al.   PLoS One

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

(2014) Cheng-Chang Chen et al.   Nature Communications

Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome

(2014) Sarah F. Hamm-Alvarez et al.   Arthritis & Rheumatology

Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein

(2013) L. Qi et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming

(2013) Khader Valli Rupanagudi et al.   ANNALS OF THE RHEUMATIC DISEASES

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

(2013) Xinming Cai et al.   CHEMISTRY & BIOLOGY

Lysosome-related organelles: unusual compartments become mainstream

(2013) Michael S Marks et al.   CURRENT OPINION IN CELL BIOLOGY

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

Dendritic cells treated with chloroquine modulate experimental autoimmune encephalomyelitis

(2013) Rodolfo Thomé et al.   IMMUNOLOGY AND CELL BIOLOGY

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

(2013) Yan Xiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

(2013) Martin Aichinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy Promotes Oligodendrocyte Survival and Function following Dysmyelination in a Long-Lived Myelin Mutant

(2013) C. M. Smith et al.   JOURNAL OF NEUROSCIENCE

A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis

(2013) Tomoko Takai et al.   MOLECULAR THERAPY

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes

(2013) Fengjuan Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal storage diseases—the horizon expands

(2013) Rose-Mary Naaman Boustany   Nature Reviews Neurology

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

(2013) Sally Martin et al.   PLoS One

Functional Analysis of Hsp70 Inhibitors

(2013) Rainer Schlecht et al.   PLoS One

Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial

(2012) Robert Zimmer et al.   ANNALS OF THE RHEUMATIC DISEASES

Enzyme Replacement Therapy for Lysosomal Diseases: Lessons from 20 Years of Experience and Remaining Challenges

(2012) R.J. Desnick et al.   Annual Review of Genomics and Human Genetics

Lysosomal dysfunction in neurodegeneration

(2012) Marija Usenovic et al.   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Autophagy in lysosomal storage disorders

(2012) Andrew P. Lieberman et al.   Autophagy

Macroautophagy is deregulated in murine and human lupus T lymphocytes

(2012) Frédéric Gros et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Discovery of a Novel Noniminosugar Acid α Glucosidase Chaperone Series

(2012) Jingbo Xiao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evidence for risk of cardiomyopathy with hydroxychloroquine

(2012) MD Sumpter et al.   LUPUS

Pharmacological Enhancement of α-Glucosidase by the Allosteric Chaperone N-acetylcysteine

(2012) Caterina Porto et al.   MOLECULAR THERAPY

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

(2012) Lin Qi et al.   PLoS One

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of core components of SCF complex in poly-glutamine disorders

(2012) S Bhutani et al.   Cell Death & Disease

Nonpeptidic Lysosomal Modulators Derived from Z-Phe-Ala-Diazomethylketone for Treating Protein Accumulation Diseases

(2012) Kishore Viswanathan et al.   ACS Medicinal Chemistry Letters

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Brief Report: A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis

(2011) Sarah Krausz et al.   ARTHRITIS AND RHEUMATISM

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

(2011) Sheng Chen et al.   BRAIN PATHOLOGY

mTOR as a multifunctional therapeutic target in HIV infection

(2011) Ferdinando Nicoletti et al.   DRUG DISCOVERY TODAY

Cysteine Proteases Bleomycin Hydrolase and Cathepsin Z Mediate N-terminal Proteolysis and Toxicity of Mutant Huntingtin

(2011) Tamara Ratovitski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection

(2011) Maurizio Renna et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

CIDP - the relevance of recent advances in Schwann cell/axonal neurobiology

(2011) John D. Pollard et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons

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Chaperone-Mediated Autophagy Is Required for Tumor Growth

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A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling

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HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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Lysosomal Degradation of α-Synucleinin Vivo

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Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study

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A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells

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Cathepsin L Inhibition Prevents Murine Autoimmune Diabetes via Suppression of CD8+ T Cell Activity

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A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

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The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase

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Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

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Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

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The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells

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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

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Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

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Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide

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Genistin-rich soy isoflavone extract in substrate reduction therapy for Sanfilippo syndrome: An open-label, pilot study in 10 pediatric patients

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Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

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Spinal Cord mRNA Profile in Patients with ALS: Comparison with Transgenic Mice Expressing the Human SOD-1 Mutant

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

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