Drug repositioning for Alzheimer's disease

Herpes Simplex Virus Type 1 in Alzheimer's Disease: The Enemy Within

(2017) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of Antihypertensive Drugs Which Inhibit Amyloid-β Protein Oligomerization

(2017) Wei Zhao et al.   JOURNAL OF ALZHEIMERS DISEASE

Reductions in Amyloid-β-Derived Neuroinflammation, with Minocycline, Restore Cognition but do not Significantly Affect Tau Hyperphosphorylation

(2017) Anna Parachikova et al.   JOURNAL OF ALZHEIMERS DISEASE

Dimebon (Latrepirdine) Enhances Mitochondrial Function and Protects Neuronal Cells from Death

(2017) Shouting Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation

(2014) Zhiyou Cai et al.   Pharmacological Reports

Amantadine: The journey from fighting flu to treating Parkinson disease

(2012) G. Hubsher et al.   NEUROLOGY

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug

(2011) P. F. Copenhaver et al.   Disease Models & Mechanisms

Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood–brain barrier

(2011) Corbin Bachmeier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

(Val8) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

(2011) Lin Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease

(2011) Grazia D'Onofrio et al.   Expert Opinion on Drug Discovery

Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer’s disease

(2011) Clive Ballard et al.   Expert Review of Neurotherapeutics

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

(2011) A. Hamilton et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

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(2011) Daniel Paris et al.   MOLECULAR MEDICINE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Chronic divalproex sodium use and brain atrophy in Alzheimer disease

(2011) A. S. Fleisher et al.   NEUROLOGY

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

Brain renin-angiotensin—A new look at an old system

(2011) John W. Wright et al.   PROGRESS IN NEUROBIOLOGY

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials

(2010) Philip B. Gorelick   Annals of the New York Academy of Sciences

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β

(2010) C. I. Jarvis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study

(2010) S. P. Kennelly et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Improvement of cognition, a potential benefit of anti-TNF therapy in elderly patients with rheumatoid arthritis

(2010) Yi-Ming Chen et al.   JOINT BONE SPINE

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

(2010) Craig Anderson et al.   LANCET NEUROLOGY

Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

(2010) Dara L. Dickstein et al.   MOUNT SINAI JOURNAL OF MEDICINE

A futility study of minocycline in Huntington's disease

(2010) Merit Cudkowicz   MOVEMENT DISORDERS

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

(2010) Simon Gengler et al.   NEUROBIOLOGY OF AGING

L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

(2010) Thimmappa S. Anekonda et al.   NEUROBIOLOGY OF DISEASE

Early-Stage Inflammation and Experimental Therapy in Transgenic Models of the Alzheimer-Like Amyloid Pathology

(2010) A.C. Cuello et al.   Neurodegenerative Diseases

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Val8-glucagon-like peptide-1 protects against Aβ1–40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

(2010) X.H. Wang et al.   NEUROSCIENCE

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

(2010) A. David Smith et al.   PLoS One

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfolding

(2010) Wendy Noble et al.   Prion

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Oral Administration of Synthetic Retinoid Am80 (Tamibarotene) Decreases Brain β-Amyloid Peptides in APP23 Mice

(2009) Kohichi Kawahara et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Towards Retinoid Therapy for Alzheimers Disease

(2009) K. Shudo et al.   Current Alzheimer Research

All-transretinoic acid as a novel therapeutic strategy for Alzheimer’s disease

(2009) Hyun-Pil Lee et al.   Expert Review of Neurotherapeutics

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathyin vivoin transgenic mice

(2009) Monica Garcia-Alloza et al.   JOURNAL OF NEUROCHEMISTRY

Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

(2009) Arne Astrup et al.   LANCET

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

(2009) Tomohiko Sato et al.   NEUROBIOLOGY OF AGING

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Intracerebroventricular amyloid-  antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

(2009) D. R. Thakker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensins in Alzheimer's disease – friend or foe?

(2009) Patrick G. Kehoe et al.   TRENDS IN NEUROSCIENCES

Telmisartan prevented cognitive decline partly due to PPAR-γ activation

(2008) Masaki Mogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease

(2008)   CLINICAL NEUROPHARMACOLOGY

Sequential RARβ and α signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways

(2008) Maria Beatriz C.V. Goncalves et al.   DEVELOPMENTAL BIOLOGY

Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease

(2008) Tarja M. Malm et al.   GLIA

A feasibility and tolerability study of lithium in Alzheimer's disease

(2008) Alastair Macdonald et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

A profile of impaired insulin degradation in relation to late-life cognitive decline: A preliminary investigation

(2008) Olivia I. Okereke et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Retinoic Acid Attenuates  -Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

(2008) Y. Ding et al.   JOURNAL OF NEUROSCIENCE

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

(2008) Gordon K Wilcock et al.   LANCET NEUROLOGY

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers

(2008) Andrew B. Scholey et al.   PSYCHOPHARMACOLOGY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL